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Published in: European Journal of Nuclear Medicine and Molecular Imaging 6/2023

Open Access 21-01-2023 | Astrocytoma | Original Article

[18F]FET-PET in children and adolescents with central nervous system tumors: does it support difficult clinical decision-making?

Authors: Olivia Kertels, Jürgen Krauß, Camelia Maria Monoranu, Samuel Samnick, Alexander Dierks, Malte Kircher, Milena I. Mihovilovic, Mirko Pham, Andreas K. Buck, Matthias Eyrich, Paul-Gerhardt Schlegel, Michael C. Frühwald, Brigitte Bison, Constantin Lapa

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 6/2023

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Abstract

Purpose

Positron emission tomography (PET) with O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) is a well-established tool for non-invasive assessment of adult central nervous system (CNS) tumors. However, data on its diagnostic utility and impact on clinical management in children and adolescents are limited.

Methods

Twenty-one children and young adults (13 males; mean age, 8.6 ± 5.2 years; range, 1–19 at initial diagnosis) with either newly diagnosed (n = 5) or pretreated (n = 16) CNS tumors were retrospectively analyzed. All patients had previously undergone neuro-oncological work-up including cranial magnetic resonance imaging. In all cases, [18F]FET-PET was indicated in a multidisciplinary team conference. The impact of PET imaging on clinical decision-making was assessed. Histopathology (n = 12) and/or clinical and imaging follow-up (n = 9) served as the standard of reference.

Results

The addition of [18F]FET-PET to the available information had an impact on further patient management in 14 out of 21 subjects, with avoidance of invasive surgery or biopsy in four patients, biopsy guidance in four patients, change of further treatment in another five patients, and confirmation of diagnosis in one patient.

Conclusion

[18F]FET-PET may provide important additional information for treatment guidance in pediatric and adolescent patients with CNS tumors.
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Literature
Metadata
Title
[18F]FET-PET in children and adolescents with central nervous system tumors: does it support difficult clinical decision-making?
Authors
Olivia Kertels
Jürgen Krauß
Camelia Maria Monoranu
Samuel Samnick
Alexander Dierks
Malte Kircher
Milena I. Mihovilovic
Mirko Pham
Andreas K. Buck
Matthias Eyrich
Paul-Gerhardt Schlegel
Michael C. Frühwald
Brigitte Bison
Constantin Lapa
Publication date
21-01-2023
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 6/2023
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-023-06114-6

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