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Open Access 29-01-2025 | ASO Author Reflections

ASO Author Reflections: Real-World Results of the KEYNOTE-522 Regimen to Guide Surgical Decision Making

Authors: Casey Connors, MD, Julie E. Lang, MD

Published in: Annals of Surgical Oncology

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Excerpt

Triple-negative breast cancer (TNBC), which is notorious for its aggressive tumor biology and overall poorer prognosis, accounts for approximately 15% of all breast cancer diagnoses.13 The KEYNOTE-522 trial introduced immunotherapy into the neoadjuvant setting for patients with stage II/III TNBC, resulting in improved pathologic complete response (PCR) rates and event-free and overall survival.4 Surgical candidacy for breast-conservation therapy (BCT) can increase following neoadjuvant systemic therapy (NAT) but is often time contingent upon the degree of clinical response. In our study, we sought to evaluate whether patients undergoing NAT using the KEYNOTE-522 regimen in a real-world setting had improved pCR that correlated with an increased rate of breast conservation compared with patients who underwent NAT using the prior standard-of-care regimen (control group).5 Additionally, we set out to evaluate BCT eligibility, effect on axillary surgery, identification of clinical characteristics to help predict pathologic response to NAT, identification of factors that influence surgery type, mean tumor reduction, and immune-related adverse events (irAEs). …
Literature
1.
go back to reference Bauer KR, Brown M, Cress RD, Parise CA, Caggiano V. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry. Cancer. 2007;109(9):1721–8. https://doi.org/10.1002/cncr.22618.CrossRefPubMed Bauer KR, Brown M, Cress RD, Parise CA, Caggiano V. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry. Cancer. 2007;109(9):1721–8. https://​doi.​org/​10.​1002/​cncr.​22618.CrossRefPubMed
Metadata
Title
ASO Author Reflections: Real-World Results of the KEYNOTE-522 Regimen to Guide Surgical Decision Making
Authors
Casey Connors, MD
Julie E. Lang, MD
Publication date
29-01-2025
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-025-16931-8
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