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09-05-2024 | ASO Author Reflections

ASO Author Reflections: A Novel Mechanism of Anticancer Effect of Skeletal Muscle-Derived Irisin in Pancreatic Ductal Adenocarcinoma

Authors: Tomoki Sugimoto, MD, Yoshifumi Iwagami, MD, PhD, Shogo Kobayashi, MD, PhD, Chihiro Yamanaka, MD, PhD, Kazuki Sasaki, MD, PhD, Daisaku Yamada, MD, PhD, Yoshito Tomimaru, MD, PhD, Tadafumi Asaoka, MD, PhD, Takehiro Noda, MD, PhD, Hidenori Takahashi, MD, PhD, Junzo Shimizu, MD, PhD, Yuichiro Doki, MD, PhD, Hidetoshi Eguchi, MD, PhD

Published in: Annals of Surgical Oncology | Issue 8/2024

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Excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in the world.1 Finding a new therapeutic target for PDAC holds significant importance. It is reported that PDAC patients with high skeletal muscle mass experience better long-term prognosis compared with low skeletal muscle.2 Therefore, we focused on skeletal muscle and its secreted cytokines defined as myokines.3 Irisin, one of the myokines, is reported to exist as an extracellular part of Fibronectin Type III Domain-containing Protein 5 (FNDC5). It has been reported that most irisin is released from skeletal muscle.4 We tried to elucidate the effects of irisin derived from skeletal muscle in PDAC cells and the underlying mechanisms. …
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Metadata
Title
ASO Author Reflections: A Novel Mechanism of Anticancer Effect of Skeletal Muscle-Derived Irisin in Pancreatic Ductal Adenocarcinoma
Authors
Tomoki Sugimoto, MD
Yoshifumi Iwagami, MD, PhD
Shogo Kobayashi, MD, PhD
Chihiro Yamanaka, MD, PhD
Kazuki Sasaki, MD, PhD
Daisaku Yamada, MD, PhD
Yoshito Tomimaru, MD, PhD
Tadafumi Asaoka, MD, PhD
Takehiro Noda, MD, PhD
Hidenori Takahashi, MD, PhD
Junzo Shimizu, MD, PhD
Yuichiro Doki, MD, PhD
Hidetoshi Eguchi, MD, PhD
Publication date
09-05-2024
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 8/2024
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-024-15349-y

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