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16-05-2024 | Arthritis | Original Contribution

Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model

Authors: Angela M. Laevski, Mélina R. Doucet, Marco S. Doucet, Audrée A. LeBlanc, Paskale E. Pineau, Mathieu P. A. Hébert, Jérémie A. Doiron, Patrick Roy, Maroua Mbarik, Alexis J. Matthew, Eric P. Allain, Marc E. Surette, Luc H. Boudreau

Published in: European Journal of Nutrition | Issue 6/2024

Abstract

Purpose

The aim of this study was to investigate the effects of different ω-3 polyunsaturated fatty acid (PUFA) enriched diets, including a novel renewable plant source of ω-3 fatty acids (Buglossoides arvensis), on the development and progression of rheumatoid arthritis (RA).

Methods

RA was induced in mice consuming experimental diets using the K/BxN model. The experimental diets consisted of either a western control diet (control), diets containing B. arvensis oil or fish oil. The effects of the diets on platelets, platelet microvesicles (PMVs), and inflammatory markers such as clinical index, ankle thickness and cytokine/chemokine release were measured.

Results

While ω-3 PUFA-enriched diets did not prevent the development of arthritis in the K/BxN model, a significant decrease in ankle swelling was observed compared to the control group. Platelets isolated from mice consuming either low content of B. arvensis oil or fish oil diets exhibited significantly decreased PMVs production compared to mice consuming the control diet.

Conclusion

Our study provides insight into the contribution of ω-3 PUFA supplementation in modulating the pro-inflammatory phenotype of platelets in RA pathology. Furthermore, our study suggests that low concentrations of dietary B. arvensis oil may have similar anti-inflammatory potential seen with dietary fish oil supplementation.

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Title: Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model
Authors: Angela M. Laevski
Mélina R. Doucet
Marco S. Doucet
Audrée A. LeBlanc
Paskale E. Pineau
Mathieu P. A. Hébert
Jérémie A. Doiron
Patrick Roy
Maroua Mbarik
Alexis J. Matthew
Eric P. Allain
Marc E. Surette
Luc H. Boudreau
Publication date: 16-05-2024
Publisher: Springer Berlin Heidelberg
Keywords: Arthritis
Rheumatoid Arthritis
Published in: European Journal of Nutrition / Issue 6/2024
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-024-03397-9

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Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model

Abstract

Purpose

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Results

Conclusion

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Abstract

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Conclusion

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