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Tirzepatide boosts ixekizumab benefits in patients with PsA and obesity

Combining ixekizumab with tirzepatide offers additive clinical benefits over ixekizumab alone in the treatment of psoriatic arthritis in patients with overweight or obesity.

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Editor's Choice

Stroke in autoimmune rheumatic diseases

Patients with ARDs have a significantly increased risk for stroke. Review the epidemiology, pathophysiological mechanisms, clinical characteristics, prevention strategies, and post-stroke rehabilitation in this patient population.

Insights into autoimmune-related DED

Autoimmune-related dry eye disease is often refractory to conventional first-line treatments, with anti-inflammatory and immunomodulatory therapies instead crucial for long-term control. This stepwise approach provides insights from real-world cases.

Infrared thermography in the detection of arthritis

Early detection of arthritis is critical to prevent irreversible damage. Joint ultrasound offers high sensitivity and availability in routine clinical practice, but it has limitations. Could infrared thermography play a role?

Advances in JIA-associated uveitis

Juvenile idiopathic arthritis-associated uveitis is an important cause of childhood and adult visual impairment. Discover recent developments in disease stratification, imaging, pharmacologic management, and psychosocial support.

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Case Studies

Late-onset axSpA presenting with fever

The first report of late-onset axial spondyloarthritis presenting with fever of unknown origin. Physicians need to be aware of rare manifestations of ax-SpA in the elderly population.

Methotrexate-associated gynecomastia

A reminder to consider methotrexate as a potential cause of gynecomastia, even with long-term low-dose therapy and in euhormonal states. Conservative measures such as dose reduction or folate supplementation may lead to symptom reversal.

Rare constellation of overlapping autoimmune diseases

A unique case of both MOGAD and emergent lupus developing after anti-TNF treatment in a patient with ankylosing spondylitis, highlighting the need for increased clinical awareness of the immunological consequences of TNF blockade.

Current Reviews

Chimeric antigen receptor macrophage (CAR-M) immunotherapy in autoimmune inflammatory rheumatic diseases

Chronic autoimmune inflammatory rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), juvenile idiopathic arthritis, systemic sclerosis (SSc), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) …

Potential of CAR-T cell immunotherapy in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint destruction. Despite the availability of various treatment options, many patients remain refractory to conventional therapies. Recent advancements in …

Luteolin in osteoarticular diseases: a review of preclinical studies and translational perspectives

Osteoarticular diseases, including degenerative, inflammatory, genetic, and metabolic subtypes, cause severe physical impairment, psychological distress, and substantial economic burden globally. Current therapies often fail to halt progression or …

Regulatory T cells as a potential treatment for autoimmune inflammatory rheumatic and musculoskeletal diseases

Autoimmune diseases result from the immune system’s inability to distinguish between self and non-self, destroying healthy tissue. T regulatory cells (Tregs) are a unique subset of CD4 + T cells, which play a crucial role in immune tolerance and …

Further Reading

Comorbidity patterns and health-related quality of life in a cohort of Australian women cancer survivors

The number of people living with cancer (cancer survivors) is growing rapidly, with major contributions from population ageing, advances in early detection, and improvement in cancer treatment [ 1 ]. In Australia alone, on average, 463 new cancer …

Sodium and potassium intake in rheumatoid arthritis: a systematic review of clinical studies with implications for disease-related outcomes

Rheumatoid arthritis (RA) is characterized by immune-mediated inflammation resulting in excess cardiovascular disease (CVD) risk. Increased sodium, decreased potassium intake and their ratio have been acknowledged as CVD risk modifiers, while …

Systemic lupus erythematosus is associated with an increased risk for orthorexia nervosa: a cross-sectional study

Orthorexia nervosa (ON) is an atypical eating disorder marked by persistent preoccupation with consuming only ‘pure’ or healthy foods, coupled with harmful compulsive behaviors. Rheumatic and musculoskeletal diseases (RMDs) are a broad group of …

Clinical outcomes of molecular-targeted therapies for rheumatoid arthritis: comparison between orthopaedic surgeons and rheumatologists in the multicenter retrospective ANSWER cohort

Biologic disease-modifying antirheumatic drugs (bDMARDs), including tumor necrosis factor inhibitors (TNFi), anti-interleukin-6 receptor antibodies (aIL-6Ra), and cytotoxic T-lymphocyte antigen 4–immunoglobulin fusion protein (CTLA4-Ig), and Janus …

Image Credits
Woman receiving injection/© Antonio_Diaz / Getty Images / iStock (symbolic image with models), Stroke illustration/© Thipphaphone / Generated with AI / stock.adobe.com, Clinical images of elderly male with SS-associated dry eye disease/© 2026, Giuseppe Giannaccare et al, Ophthalmol Ther (CC BY 4.0), Infrared visualization of shoulder pain or injury/© mikkelwilliam / Getty Images / iStock, Girl covering one eye with her hand/© patpitchaya / Getty Images / iStock (symbolic image with model), Close-up of doctor giving subcutaneous injection in patient's stomach/© Victoria Kotlyarchuk / Getty Images / iStock, Person using prefilled syringe or pen injection/© M.Dörr & M.Frommherz / stock.adobe.com, Vagus nerves, illustration/© SEBASTIAN KAULITZKI / SCIENCE PHOTO LIBRARY / Getty Images, Red target surrounded by blue arrows/© MicroStockHub / Getty Images / iStock, Close-up of person taking a pill out of a blister packet/© vm / Getty Images / iStock, Close-up of hand holding a digital thermometer/© Patrick Daxenbichler / stock.adobe.com, Chest CT of patient with methotrexate-associated gynecomastia/© 2026, Hiroshi Shiba et al, under exclusive licence to International League of Associations for Rheumatology, Clin Rheumatol, Spine MRI of patient with overlapping autoimmunity and demyelination syndromes/© 2026, Rula Daood et al, under exclusive licence to International League of Associations for Rheumatology, Clin Rheumatol