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Renal involvement in spondyloarthropathies

How prevalent are renal abnormalities across the spectrum of seronegative spondyloarthritis? And what are the associated risk factors and underlying pathophysiology?

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Editor's Choice

Safety of rapid rituximab infusion in rheumatic diseases

A systematic evaluation of the evidence for accelerated infusion of rituximab in people autoimmune rheumatic diseases. The practice appears safe and feasible but prospective studies are needed.

Late-onset RA: what you need to know

Learn about the clinical features, diagnostic challenges, and treatment approaches for late-onset rheumatoid arthritis, defined as disease diagnosed after the age of 60 years.

POETYK trial shows clinical benefit of deucravacitinib in PsA

Treatment with the TYK2 inhibitor deucravacitinib improved disease activity, joint and skin symptoms, and quality of life among people with active psoriatic arthritis participating in the POETYK PsA-1 trial 

Rheumatoid arthritis and family planning

Equip yourself to counsel your patients with rheumatoid arthritis about reproductive health concerns, such as contraception safety, infertility, and the management of RA medications during pregnancy and breastfeeding.

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Case Studies

Novel association of chilblains with inflammatory arthritis

Three patients with inflammatory arthritis had concomitant chilblains and bone marrow edema as revealed by MRI. Could this trifecta represent a new clinical phenotype of seronegative spondyloarthropathies?

Digital vasculitis as rare presentation of anti-synthetase syndrome

The patient presented with digital vasculitis, rapidly evolving interstitial lung disease, sub-clinical myositis, and arthritis of the hands with no prior history of Raynaud’s phenomenon. What antibodies would you test to determine the final diagnosis?

Tuberculosis of the elbow joint

Elbow tuberculosis is a rare manifestation of TB, with symptoms often mimicking diseases such as rheumatoid or septic arthritis. Surgical intervention can greatly benefit diagnosis, but is not always necessary for successful treatment.

Current Reviews

Kaempferol as a multi-targeted phytotherapeutic for arthritis: systematic review and meta-analysis of preclinical models

Arthritis, including rheumatoid arthritis (RA), osteoarthritis (OA), and gouty arthritis (GA), is a major cause of disability worldwide. Current treatments have limited efficacy and adverse effects, prompting interest in natural alternatives.

Low adherence to cardiovascular risk assessment guidelines in patients with rheumatoid arthritis: a retrospective chart review of routine clinical practice

Patients with rheumatoid arthritis (RA) have an increased risk of developing cardiovascular disease (CVD), resulting in heart failure, myocardial infarction, and stroke [ 1 , 2 ]. Meta-analyses of European and North American population-based …

Physical activity of older patients with rheumatoid arthritis

Rheumatoid arthritis (RA) in older adults presents a complex clinical challenge, exacerbated by age-related comorbidities, musculoskeletal degeneration, and psychosocial factors, all contributing to significant mobility limitations and reduced …

Targeting rheumatoid arthritis risk factors with phytochemicals: an anti-inflammatory perspective

Inflammation is a fundamental immunological response to external stimuli or damage caused by pathogens. Inflammatory disorders can be categorized to acute or chronic joint diseases. Rheumatoid arthritis (RA) is classified as an inflammatory …

Further Reading

Efficacy and Safety of Deucravacitinib, a Selective, Allosteric TYK2 Inhibitor, by Baseline DMARD Use in a Phase 2 Psoriatic Arthritis Study: A Post Hoc Analysis

This article is published with digital features, including a graphical abstract, to facilitate understanding of the article. To view digital features for this article, go to https://doi.org/10.6084/m9.figshare.29077367 .

Efficacy of Intravenous Immunoglobulin for Systemic Manifestations of Dermatomyositis Beyond Muscular and Cutaneous: Sub-analysis of the ProDERM Study

Dermatomyositis (DM) is an inflammatory myopathy typically characterized by progressive muscle weakness and skin symptoms, which is estimated to affect between one and 21 people per 100,000 of the US population [ 1 – 3 ]. Muscle and skin …

Guselkumab Retention, Effectiveness, and Safety in Psoriasis: A 260-Week Real-World Multicenter Retrospective Study Exploring the Role of Concomitant PsA–IL PSO (Italian Landscape Psoriasis)

Plaque psoriasis is a chronic, immune-mediated inflammatory skin disease characterized by erythematous plaques covered with thick, silvery-white scales [ 1 , 2 ]. This condition affects patients of all ages, significantly impacting their physical …

Low adherence to cardiovascular risk assessment guidelines in patients with rheumatoid arthritis: a retrospective chart review of routine clinical practice

Patients with rheumatoid arthritis (RA) have an increased risk of developing cardiovascular disease (CVD), resulting in heart failure, myocardial infarction, and stroke [ 1 , 2 ]. Meta-analyses of European and North American population-based …