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Current Cardiology Reports

Systematic Review of Literature Citing the ISCHEMIA Trial

  • 16-03-2024
  • Arterial Diseases
  • New Therapies for Cardiovascular Disease (AA Bavry and MR Massoomi, Section Editors)
Published in:
Authors
David J. King
Christian Eskander
Jacob Ricci
David Gittess
Rushi Patel
Mitchell Bourne
Jeffery Budweg
David E. Winchester
Published in
Current Cardiology Reports | Issue 5/2024

Abstract

Purpose of Review

Optimal therapy for patients with chronic coronary artery disease (CCD) has long been a topic under investigation and a subject of debate. Seeking to clarify appropriate management, the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial compared medical management versus coronary angiography for patients with stable ischemic heart disease. Its reception in the medical community has been met with both acclaim and criticism. In light of such disparate views of this trial, a systematic review of the literature citing the ISCHEMIA trial was performed.

Recent Findings

All articles citing the ISCHEMIA trial on PubMed as of July 21, 2023, were compiled and underwent qualitative analysis.
A total of 430 articles were evaluated; 109 (25.3%) did not offer substantial commentary on ISCHEMIA and cite it as background evidence for further study. Of the commentary articles, the majority (224, 52.1%) gave balanced, honest appraisals of the ISCHEMIA trial. A total of 46 (10.7%) strongly praised the trial while another 39 (9.1%) were strongly critical of the results.

Summary

Almost three-quarters of the literature citing the ISCHEMIA trial was commentary in nature, with roughly equal distribution across the spectrum of praise and criticism. Despite being one of the largest studies on CCD and coronary revascularization ever conducted, the impact of ISCHEMIA on the cardiology community appears to be mixed.
Title
Systematic Review of Literature Citing the ISCHEMIA Trial
Authors
David J. King
Christian Eskander
Jacob Ricci
David Gittess
Rushi Patel
Mitchell Bourne
Jeffery Budweg
David E. Winchester
Publication date
16-03-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 5/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02031-8
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Independent Medical Education Grant:
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Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME