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Journal of Neural Transmission

04-01-2025 | Anxiety | Psychiatry and Preclinical Psychiatric Studies - Review Article

Untangling the complex relationship between bipolar disorder and anxiety: a comprehensive review of prevalence, prognosis, and therapy

Authors: Yuting Wang, Jiao Liu, Ran Zhang, Guoshuai Luo, Daliang Sun

Published in: Journal of Neural Transmission

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Abstract

Bipolar disorder (BD) frequently coexists with anxiety disorders, creating complex challenges in clinical therapy and management. This study investigates the prevalence, prognostic implications, and treatment strategies for comorbid BD and anxiety disorders. High comorbidity rates, particularly with generalized anxiety disorder, underscore the necessity of thorough clinical assessments to guide effective management. Our findings suggest that anxiety disorders may serve as precursors to BD, especially in high-risk populations, making early detection of anxiety symptoms crucial for timely intervention and prevention. We also found that comorbid anxiety can negatively affect the course of BD, increasing clinical severity, reducing treatment responsiveness, and worsening prognosis. These complexities highlight the need for caution in using antidepressants, which may destabilize mood. Alternatively, cognitive-behavioral therapy presents a promising, targeted approach for managing BD with comorbid anxiety. In summary, this study provides essential insights for clinicians and researchers, enhancing understanding of BD and anxiety comorbidity and guiding more precise diagnostics and tailored interventions to improve overall patient care.
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Metadata
Title
Untangling the complex relationship between bipolar disorder and anxiety: a comprehensive review of prevalence, prognosis, and therapy
Authors
Yuting Wang
Jiao Liu
Ran Zhang
Guoshuai Luo
Daliang Sun
Publication date
04-01-2025
Publisher
Springer Vienna
Keyword
Anxiety
Published in
Journal of Neural Transmission
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-024-02876-x

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