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30-09-2024 | Antidepressant Drugs | Review Article

Prevalence of Antidepressant Prescriptions for Community-Dwelling Adults Diagnosed with Depressive Disorder in the UK: A Systematic Review

Authors: Lea Francia, Roberto Mediavilla, Lok Yin Choi, José Luis Ayuso-Mateos, Riccardo De Giorgi

Abstract

The UK National Institute for Health and Care Excellence (NICE) guidance for the treatment of depression is widely followed and has international influence. According to these guidelines, antidepressant medications are recommended for moderate to severe depression. Nonetheless, antidepressants are increasingly prescribed, including for cases of subthreshold and mild depression. This may indicate that a proportion of depressed patients uses pharmacological interventions with unclear evidence-base, though other factors such as physical and mental health comorbidities need to be accounted for. This study aims to investigate the prevalence and trends of antidepressant prescriptions among community-dwelling adults diagnosed with depression according to NICE recommendations. We conducted a systematic review of PsycInfo, PubMed/MEDLINE, and Scopus databases. Observational studies reporting on the prevalence of antidepressant treatments in UK adults diagnosed with depression were sought. Fifteen studies were included. The prevalence of antidepressants for depression treatment ranged from 30.8 to 95% and mainly concerned selective serotonin reuptake inhibitors (SSRIs) among classes of antidepressant drugs. Little information about depression severity as well as comorbid conditions was reported. High prevalence rates of antidepressant drug use highlight the widespread adoption of pharmacological interventions, while also raising concerns about compliance with NICE guidelines. Careful assessment of depressive illness severity and comorbidities is needed to ensure the delivery of adequate care to people with depression. Systematic Review Registration Number (PROSPERO) CRD42023448152.

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Title: Prevalence of Antidepressant Prescriptions for Community-Dwelling Adults Diagnosed with Depressive Disorder in the UK: A Systematic Review
Authors: Lea Francia
Roberto Mediavilla
Lok Yin Choi
José Luis Ayuso-Mateos
Riccardo De Giorgi
Publication date: 30-09-2024
Publisher: Springer US
Keywords: Antidepressant Drugs
Antidepressant Drugs
Published in: Psychiatric Quarterly
Print ISSN: 0033-2720
Electronic ISSN: 1573-6709
DOI: https://doi.org/10.1007/s11126-024-10093-8

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Prevalence of Antidepressant Prescriptions for Community-Dwelling Adults Diagnosed with Depressive Disorder in the UK: A Systematic Review

Abstract

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Abstract

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