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17-02-2023 | Antibiotic | Correspondence

Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter. Author’s reply

Authors: Tim M. J. Ewoldt, Alan Abdulla, Anouk E. Muller, Henrik Endeman, Birgit C. P. Koch, the DOLPHIN Investigators

Published in: Intensive Care Medicine | Issue 4/2023

Excerpt

We would like to thank Liebchen et al. [ 1] for their comments on our article. [ 2] Furthermore, we would like to thank Cotta and colleagues, who wrote a relevant editorial regarding the same topic [ 3]. Both groups commented on the design of the trial and discussed the limitations. We take this opportunity to respond to their comments. …

Liebchen U, Briegel J, Brinkmann A, Frey O, Wicha SG (2023) Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter. Intensive Care Med. https://doi.org/10.1007/s00134-023-06990-4 CrossRefPubMedPubMedCentral

Ewoldt TMJ, Abdulla A, Rietdijk WJR, Muller AE, de Winter BCM, Hunfeld NGM, Purmer IM, van Vliet P, Wils E-J, Haringman J, Draisma A, Rijpstra TA, Karakus A, Gommers D, Endeman H, Koch BCP (2022) Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial. Intensive Care Med 47:1332–1333. https://doi.org/10.1007/s00134-022-06921-9 CrossRef

Cotta MO, Lipman J, De Waele J (2023) Advancing precision-based antimicrobial dosing in critically ill patients. Intensive Care Med. https://doi.org/10.1007/s00134-022-06969-7 CrossRefPubMed

Yang N, Wang J, Xie Y, Ding J, Wu C, Liu J, Pei Q (2022) External evaluation of population pharmacokinetic models to inform precision dosing of meropenem in critically ill patients. Front Pharmacol 13:838205 CrossRefPubMedPubMedCentral

Title: Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter. Author’s reply
Authors: Tim M. J. Ewoldt
Alan Abdulla
Anouk E. Muller
Henrik Endeman
Birgit C. P. Koch
the DOLPHIN Investigators
Publication date: 17-02-2023
Publisher: Springer Berlin Heidelberg
Keyword: Antibiotic
Published in: Intensive Care Medicine / Issue 4/2023
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-023-07002-1

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Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter. Author’s reply

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