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12-05-2024 | Note

Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus

Authors: Xiaoli Wang, Zhenyu Zan, Jun Chi, An Huang, Danyang Zhang, Houli Jiang, Yi Li, Jun Luo

Published in: Journal of Natural Medicines | Issue 4/2024

Abstract

Two new lindenane-type sesquiterpenoid dimers, chlotrichenes C and D (1 and 2) together with five known lindenane-type sesquiterpenoid dimers (3–7) were isolated from the roots of Chloranthus holostegius var. trichoneurus, a famous natural medicine named as “Sikuaiwa” for subduing swellings and relieving pain. The structures including absolute configuration were elucidated by their 1D and 2D NMR, HRESIMS, and ECD data. Compounds 1 and 2 were classical [4 + 2] lindenane-type sesquiterpenoid dimers that differed from known analogs in oxidation profile, side chain profile, and double bond position. The new isolates and compound 3 exhibited significant inhibitory activity on IL-1β production (IC₅₀: 1–15 μM) in LPS-induced THP-1 cells and other compounds exhibited inhibitory activity on NO production in LPS-induced RAW 264.7 cells (IC₅₀: 24–33 μM).

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Title: Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus
Authors: Xiaoli Wang
Zhenyu Zan
Jun Chi
An Huang
Danyang Zhang
Houli Jiang
Yi Li
Jun Luo
Publication date: 12-05-2024
Publisher: Springer Nature Singapore
Published in: Journal of Natural Medicines / Issue 4/2024
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-024-01817-y

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Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus

Abstract

Graphical abstract

Other articles of this Issue 4/2024

Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China

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Abstract

Graphical abstract

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Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China

Chemical quality evaluation and characteristics of interspecific hybrid (G. uralensis × G. glabra) C-18 strain as a new Licorice cultivar

Development of a determination method for quality control markers utilizing metabolic profiling and its application on processed Zingiber officinale Roscoe rhizome

Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara

Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities

Di-caffeoylquinic acid: a potential inhibitor for amyloid-beta aggregation