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Annals of Hematology

Issue 3/2025

Content (77 Articles)

Evolution of frontline treatment for multiple myeloma: clinical investigation of quadruplets containing carfilzomib and anti-CD38 monoclonal antibodies

Luciano J. Costa, Francesca Gay, Ola Landgren, María-Victoria Mateos, Philippe Moreau, Cyrille Touzeau, Franziska Ertel, Ian McFadden, Rani Najdi, Katja Weisel

Correction to: Evolution of frontline treatment for multiple myeloma: clinical investigation of quadruplets containing carflzomib and antiCD38 monoclonal antibodies

Luciano J. Costa, Francesca Gay, Ola Landgren, María-Victoria Mateos, Philippe Moreau, Cyrille Touzeau, Franziska Ertel, Ian McFadden, Rani Najdi, Katja Weisel

Tumor microenvironment as a novel therapeutic target for lymphoid leukemias

Shahrzad Mousavi, Soheil Nouri, Arezoo Sadeghipour, Amir Atashi

Comparative efficacy of venetoclax-based regiments in the management of chronic lymphocytic leukemia: a systematic review and metanalysis

Abdur Jamil, Shehroz Aslam, Rida Riaz, Zaheer Qureshi, Hamzah Akram, Asim Kichloo, Insija Ilyas Selene

Significance of targeting DNMT3A mutations in AML

Guiqin Huang, Xiaoya Cai, Dengju Li

TIGIT/PVR axis regulates anti-tumor immunity in hematologic malignancies

Fanqiao Meng, Maoyuan Xiang, Yu Liu, Dongfeng Zeng

Overview of 1q abnormalities in multiple myeloma: scientific opinions from Italian experts

Mattia D’Agostino, Marina Martello, Lorenzo De Paoli, Silvia Mangiacavalli, Daniele Derudas, Francesca Fazio, Anna Furlan, Carmine Liberatore, Giuseppe Mele, Roberto Mina, Roberto Ria, Elena Zamagni

Mutational heterogeneities in STAT3 and clonal hematopoiesis-related genes in acquired pure red cell aplasia

Toru Kawakami, Fumihiro Kawakami, Shuji Matsuzawa, Taku Yamane, Yuga Mizuno, Ami Asakura, Daigo Higano, Shotaro Miyairi, Kaoko Sakai, Sayaka Nishina, Hitoshi Sakai, Yasushi Kubota, Yumiko Higuchi, Hideyuki Nakazawa, Fumihiro Ishida

Rapid detection of genetic modifiers of β-thalassemia based on MALDI-TOF MS

Li Huang, Qianqian Zhang, Yuhua Ye, Yong Long, Haoyang Huang, Chao Niu, Bin Lin, Lilan Zeng, Yuxi Wang, Tingting Dai, Xiaoyun Hua, Xiangmin Xu

Racial disparities in cardiovascular manifestations among patients with sickle cell trait: analysis of national inpatient sample data (2016–2020)

Praneeth Reddy Keesari, Charan Thej Reddy Vegivinti, Medha Rajamanuri, Ahmad Mustafa, Ngowari Pokima, Lauren Haley White, Hasnain Chaudhry, Chamberline E Ozigbu, Khairul A Siddiqi, Suzanne El-Sayegh, Meekoo Dhar, Ugochi Olivia Ogu

Challenges in managing iTTP: insights into ADAMTS13 inhibitor boosting during caplacizumab therapy

Haruyuki Tanaka, Kazuya Sakai, Shusuke Tamura, Hiroya Shiwaku, Junko Nakamura, Yasunori Ueda, Seiya Bamba, Masashi Nishikubo, Yuya Nagai, Masanori Matsumoto

The efficacy of immunosuppressive therapy with or without thrombopoietin receptor agonist in elderly patients with severe aplastic anemia

Jianping Li, Yimeng Shi, Baohang Zhang, Wenrui Yang, Liping Jing, Li Zhang, Bing Han, Jun Shi, Weiping Yuan, Sidan Li, Fengkui Zhang, Xin Zhao

Assessment of anemia recovery using peripheral blood smears by deep semi-supervised learning

Qianming Yan, Yingying Zhang, Lei Wei, Xuehui Liu, Xiaowo Wang

The impact of various types of α-thalassemia on perinatal complications and pregnancy outcomes in pregnant women

Yi Li, Yuanyuan Feng, Yiyun Wei, Jing Huang, Hui Chen, Changqiang Wei, Kaiyi Wei, Lihong Pang

Sickle cell disease and opioid overdose outcomes in the United States: a nationwide analysis

Anna L. Bode, Oscar F. Borja-Montes, Mohammed A. Quazi, Aqsa Mumtaz, Amir H. Sohail, Christopher R. Smith, Muhammad Rizwan Khawaja, Abu Baker Sheikh

Gilteritinib versus salvage chemotherapy in predominantly Asian patients with relapsed/refractory FLT3-mutated acute myeloid leukemia: a regional analysis of COMMODORE in China, South-East Asia, and Russia

Bin Jiang, Jian Li, Ligen Liu, Xin Du, Hao Jiang, Jianda Hu, Xiaoxi Zeng, Taishi Sakatani, Masanori Kosako, Yaru Deng, Larisa Girshova, Sergey Bondarenko, Lily Wong Lee Lee, Archrob Khuhapinant, Elena Martynova, Nahla Hasabou, Jianxiang Wang

A phase 1 study of durvalumab as monotherapy or combined with tremelimumab with or without azacitidine in patients with myelodysplastic syndrome

Guillermo Garcia-Manero, Manila Gaddh, Uwe Platzbecker, R. Coleman Lindsley, Sarah M. Larson, Timothy Chevassut, Pierre Fenaux, Rami Komrokji, Roger Lyons, Aref Al-Kali, Yu Jiang, John Bothos, Danielle M. Townsley, Amer M. Zeidan

Contribution of molecular characterization to the diagnosis of MPN in patients with low JAK2V617F variant allelic fraction in a real-world cohort

  • Open Access
  • Research

Benjamin Lebecque, Carolyne Croizier, Thomas Tassin, Esteban Louis, Nathalie Tribalat, William Bombardier, Anne-Pascale Grandjean, Vanessa Pante, Hélène Monjanel, Jean-Baptiste Bouillon-Minois, Rémi Martel, Albane Ledoux-Pilon, Nathalie Boiret-Dupré, Benoit De Renzis, Marc Gabriel Berger, Céline Bourgne

Azacitidine in combination with HAG for newly diagnosed and relapsed/refractory AML: a prospective cohort study

Hong Pan, Zhen Gao, Yu Lian, Jingyu Zhao, Lele Zhang, Weiwang Li, Ruonan Li, Qian Liang, Jing Xu, Liyun Li, Xiao Yu, Zhexiang Kuang, Jun Shi, Liwei Fang

Treatment patterns and healthcare resource utilization in ruxolitinib-treated patients with myelofibrosis with and without anemia: a real-world analysis

Tom Liu, Mirko Fillbrunn, Shiyuan Zhang, Jingyi Chen, Weilong Li, Julia Platt, Nicole Niehoff, Gautam Sajeev, James Signorovitch

Efficacy of venetoclax combined with homoharringtonine and cytarabine for younger adults with newly diagnosed AML

Bao-Quan Song, Xin Kong, Yin Liu, Yan Pu, Jian Zhang, De-Pei Wu, Hui-ying Qiu

Exploring perceptions in the management and treatment of polycythaemia vera in the UK

Becky Bagnall, Claire Woodley, Rozinder Bains, Katherine Gibson, Amir Nawaz, Jacqueline Ryan, Mary Frances McMullin

Anti-CD20 maintenance strategies to face the challenge of COVID-19 pandemic in follicular lymphoma: results from the R-FolSTOP multicentre Italian study

Alessia Castellino, Lorenzo Comba, Laura Bertolotti, Carola Boccomini, Michele Clerico, Paolo Nicoli, Anna Vanazzi, Fulvia Fanelli, Tommasina Perrone, Francesco Marchesi, Federica Cocito, Michele Merli, Sara Bigliardi, Bianca Mecacci, Valentina Bozzoli, Gloria Margiotta-Casaluci, Erika Meli, Antonella Anastasia, Lucia Farina, Ombretta Annibali, Annarita Conconi, Sara Rattotti, Sara Galimberti, Claudia Castellino, Massimo Massaia

Metabolomics and machine learning approaches for diagnostic biomarkers screening in systemic light chain amyloidosis

Weiwei Xie, Zhizhen Lai, Qian Wang, Wenqiong Wang, Jin Wang, Huihui Liu, Zeyin Liang, Yujun Dong

Global, regional and national temporal trends in incidence and mortality of non-Hodgkin lymphoma from 1992 to 2021: an age-period-cohort analysis

Shanshan Tang, Jin Cao, Denan Jiang, Longzhu Zhu, Zeyu Luo, Shiyi Shan, Jiali Zhou, Jiayao Ying, Jing Wu, Peige Song, Wei Li

A predictive diagnostic model for refractory diffuse large B-cell lymphoma: a single-center retrospective cohort study

Yun Lin, Yang Sun, Chunyuan Li, Yongyue Zhang, Rongjin Zhang, Shumin Wang, Hongmei Jing, Ligang Cui

Real-world data of siltuximab for Chinese patients with iMCD: combination with BCD regimen as a potential approach for severe cases

Si-yuan Li, Yu-han Gao, Yue Dang, Long Chang, Kai-ni Shen, Hua-cong Cai, Dan-qing Zhao, Chong Wei, Jun Feng, Lu Zhang, Jian Li

The mutational landscape and its longitudinal dynamics in relapsed and refractory classic Hodgkin lymphoma

Hanno Witte, Axel Künstner, Thomas Hahn, Veronica Bernard, Stephanie Stölting, Kathrin Kusch, Kumar Nagarathinam, Cyrus Khandanpour, Nikolas von Bubnoff, Arthur Bauer, Michael Grunert, Svenja Hartung, Annette Arndt, Konrad Steinestel, Hartmut Merz, Hauke Busch, Alfred C. Feller, Niklas Gebauer

Is there still a place for autologous salvage transplantation in relapsed/refractory multiple myeloma in the era of novel therapies?

Simone Karp, Karolin Trautmann-Grill, Paul Warncke, Dominik Zolnowski, Christoph Röllig, Marcel Pannach, Jessica Zinn, Frank Kroschinsky, Anke Morgner, Malte von Bonin, Annette Hänel, Regina Herbst, Stephan Fricke, Martin Bornhäuser, Mathias Hänel, Raphael Teipel

Efficacy and mechanism of the XPO1 inhibitor selinexor combined with decitabine in T-cell lymphoblastic lymphoma

Miaomiao Meng, Xiaoyan Feng, Yue Zhang, Yuyang Gao, Lijuan Han, Zhaoming Li, Xudong Zhang, Mingzhi Zhang

Further strategies after immune checkpoint inhibitors in relapsed/refractory Hodgkin lymphoma: salvage treatments and consolidation with transplantation, experience in daily clinical practice

Cinzia Pellegrini, Beatrice Casadei, Alessandro Broccoli, Martina Cantelli, Gabriele Gugliotta, Marianna Gentilini, Matteo Carella, Vittorio Stefoni, Nicole Fabbri, Giulia Gabrielli, Lisa Argnani, Camilla Mazzoni, Pierluca Maglio, Gianmarco Bagnato, Pier Luigi Zinzani

The validation of advanced-stage Hodgkin lymphoma international prognostic index (A-HIPI) in Turkish patients with classical Hodgkin lymphoma

Oguzhan Koca, Berk Ozyurt, Aysenur Umar, Deniz Ozmen, Tugrul Elverdi, Ayse Salihoglu, Muhlis Cem Ar, Zafer Baslar, Ahmet Emre Eskazan

Gain or amplification of 1q21 in systemic light chain amyloidosis is associated with advanced Mayo stage, plasma cell disease and worse overall survival

Sara Oubari, Maria Papathanasiou, Lars Michel, Tienush Rassaf, Andreas Thimm, Tim Hagenacker, Daniela Ehling, Stefan Wieczorek, Eyad Naser, Ute Hegenbart, Stefan Schönland, Ulrich Dührsen, Hans Christian Reinhardt, Alexander Carpinteiro

Molecular profiling of cell-free DNA from classic Hodgkin lymphoma patients identifies potential prognostic clusters and corresponds with disease dynamics

Nick Veltmaat, Geok-Wee Tan, Yujie Zhong, Sophie Teesink, Martijn Terpstra, Johanna Bult, Marcel Nijland, Joost Kluiver, Arjan Diepstra, Anke van den Berg, Wouter J. Plattel

TP53 deletion is associated with poor survival of adult ALK-positive ALCL patients receiving CHOP-based chemotherapy

Seiichiro Katagiri, Daigo Akahane, Kunihiko Takeyama, Norihide Sato, Nobuyuki Takayama, Jun Ando, Hideaki Nitta, Masaaki Noguchi, Ken Naganuma, Shuji Momose, Takayuki Tabayashi, Masahiro Kizaki, Hiroshi Kawada, Yara Yukie Kikuti, Joaquim Carreras, Naoya Nakamura, Akihiko Gotoh

Building a new score system for the diagnosis and differential diagnosis of typical CLL/SLL, atypical CLL/SLL, and MCL based on the flow cytometry immunophenotyping

Emile Niyonizeye, Xiaoqian Wang, Dongyao Yan, Seidu A. Richard, Huijun Ren, Liyan Fu, Yaoyao Chen, Xiaogeng Yuan, Baohong Yue

Copy number alterations in pediatric B-cell precursor acute lymphoblastic leukemia patients and their association with patients’ outcome

Nesma E. Abdelfattah, Ghada M. Elsayed, Amira H. Soliman, Emad N. Ebeid, Mona S. El Ashry

Targeting refractory diffuse large B cell lymphoma by CAR-WEE1 T-cells: In vitro evaluation

Hadeer Mohamed Ahmed, Said Salama Moselhy, Magda I. Mohamad, Ahmed F. Soliman, Marwa N. M. Hassan, Nashwa El-Khazragy

The optimal time and clinical implications of measurable residual disease detection in mantle cell lymphoma

Yuting Yan, Yanshan Huang, Ying Yu, Zhongchao Duan, Yuxi Li, Rui Lyu, Tingyu Wang, Wenjie Xiong, Yi Wang, Qi Wang, Wei Liu, Gang An, Weiwei Sui, Yan Xu, Wenyang Huang, Mu Hao, Dehui Zou, Lugui Qiu, Shuhua Yi

Adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation and tyrosine kinase inhibitors: development and validation of a clinical prediction model based on cytogenetics, IKZF1 deletions and minimal residual disease

Jing Zheng, Yuping Zhou, Yanmin Zhao, Yi Luo, Jian Yu, Xiaoyu Lai, Jinuo Wang, Yishan Ye, Lizhen Liu, Huarui Fu, Luxin Yang, Yibo Wu, Jie Sun, Weiyan Zheng, Jingsong He, Yi Zhao, Wenjun Wu, Zhen Cai, Guoqing Wei, He Huang, Weiming Li, Jimin Shi

Hematopoietic stem cell transplantation and immunosuppressive therapy: implications of clonal haematopoiesis

Zhengwei Tan, Xinhe Zhang, Jia Feng, Yuechao Zhao, Huijin Hu, Dijiong Wu, Qinghong Yu, Yu Zhang, Liqiang Wu, Tonglin Hu, Zhengsong Yan, Baodong Ye, Wenbin Liu

The impact of obesity and its related underlying diseases on cytokine release syndrome and the efficacy of CAR-T therapy in treating B-cell malignancies

Mengyi Du, Rosanna Tryphene Massounga Mayombo, Jiachen Liu, Yinqiang Zhang, Danying Liao, Yu Hu, Heng Mei

A randomized controlled trial of conventional GVHD prophylaxis with or without teprenone for the prevention of severe acute GVHD

Wataru Kitamura, Keiko Fujii, Mitsuru Tsuge, Toshiharu Mitsuhashi, Hiroki Kobayashi, Chihiro Kamoi, Akira Yamamoto, Takumi Kondo, Keisuke Seike, Hideaki Fujiwara, Noboru Asada, Daisuke Ennishi, Ken-ichi Matsuoka, Nobuharu Fujii, Yoshinobu Maeda

Effect of major ABO blood group mismatched HSCT on blood transfusion and clinical outcomes in AA patients

Dongdi Lai, Dandan Chen, Xiaowei Chen, Ruiqing Zhou, Minglu Zhong, Xiaojie Chen, Jianyun Huang, Yanfei Lan, Xinxin Tong, Zhen Liu, Xuexin Yang, Shunqing Wang, Yaming Wei, Zhaohu Yuan

Sequential combined bypassing therapy in haemophilia patients with high titer inhibitors: surgical experience

Bingjie Ding, Xuewen Song, Liu Liu, Xiaoying Niu, Mengjuan Li, Yuanyuan Zhang, Shujun Shao, Ao Xia, Jingyuan Liu, Jing Zhang, Po Li, Fan Zhang, Guancong Liu, Zhehuang Li, Peng Zhang, Hu Zhou

Epidemiological and clinical characteristics of children and young adults with Glanzmann’s thrombasthenia in upper Egypt: a multicenter cross-sectional study

Gehan Lotfy Abdel Hakeem Khalifa, Amr Abdallah El-Sayed, Zahraa Elmasry, Khalid I. Elsayh, Zizi T. Atwa, Dalia Saber Morgan, Ebtesam Esmail Hassan, Mohmed A. Hassan, Mervat A.M. Youssef

Total psoriasis regression in a patient with chronic myeloid leukemia treated using nilotinib

Tomáš Horňák, Daniela Žáčková, Jiří Mayer

Novel ETV6::RAPGEF6 fusion gene in chronic eosinophilic leukemia: compiling evidence on the role of IL3 overexpression in tumorigenesis

Mathilde Iberti, Michael Loschi, Frédérique Keslair, Marcel Deckert, Estelle Pichery, Ilaria Di Mauro, Valérie Duranton-Tanneur, Corinne Ferrero, Youta Fanjat, Pierre Toulon, Thomas Cluzeau, Bérengère Dadone-Montaudié

Mixed-phenotype leukemia with TCF3::ZNF384 fusion presenting as an isolated mediastinal mass

Wing-Yan Au, Chit Chow, Ka-Fai To, Edmond S.K. Ma, Eugene C.L. Yeung, Wai-Lun Yip, Helen M.H. Chan, Harinder Gill

Rare case of pure red cell aplasia secondary to smoldering multiple myeloma successfully treated with daratumumab – case report and review of the literature

Malak Alharbi, Sawyer Bawek, Ian Lund, Sean T. Glenn, Steven Green, Hamza Hassan, You-Wen Qian, Jens Hillengass

Novel AK-1 gene variants combined with thalassemia causing rare hereditary non-spherocytic hemolytic anemia in a Chinese family

Lizhu Chen, Xiaobao Wei, Chengcheng Zheng, Xiaoli Liu, Jun Huang, Meiyu Zhang, Hui Chen, Ying Que, Ning Tang, Dejian Yuan, Qingyan Zhong

Unusual peripheral T-cell lymphoma with a cytotoxic phenotype presenting in the pancreas

Juliette Dubois, Sarah Bellal, Marie-Christine Copin, Paul Mallet-Guy, Clément Bouron, Adrien Lannes, Aline Tanguy-Schmidt, Mathilde Hunault-Berger, Jérôme Paillassa

Twin pregnancy during treatment with asciminib for chronic myeloid leukemia – a case report

Géssika B. G. M. Gutierrez de Moraes Pereira, Victor A. Rocha, Paulo Victor R. Barbosa, Christopher Cralcev, Alice V. de Jesus, Mariana B. Spadoni, Teresa Vilela V. Pereira, João Paulo C. Magalhães, Gislaine O. Duarte, Guilherme Duffles, Felipe S. Maia, Fernanda Surita, José Paulo S. Guida, Carmino Antonio de Souza, Maria Laura Costa, Katia B. B. Pagnano

Combined heterozygosity for hemoglobin Paksé, α-thalassemia and for hemoglobin E, β- thalassemia ̵ first appearance in Europe

Wolfgang J. Schnedl, Georg Leixner, Astrid Voill-Glaninger, Simon Michaelis, Dietmar Enko, Harald Mangge

Tirabrutinib for CNS relapsed primary vitreoretinal lymphoma

Nao Yoshida, Hiroshi Ureshino, Tomona Hiyama, Yosuke Harada, Suzuka Nakatani, Ren Chishaki, Taro Edahiro, Tetsumi Yoshida, Takero Shindo, Tatsuo Ichinohe

Polatuzumab vedotin and bendamustine (Pola-B) was effective for refractory CD20-negative double-expressor lymphoma

Midori Ogasawara, So Okubo, Kohei Shinmura, Hitomi Nakayama, Aki Sakurai, Chisako Ito, Yoshinobu Aisa, Tomonori Nakazato

When high dose methotrexate stops working, a successful bridge to transplant with TEDDI-R in a case of secondary CNS lymphoma

Süreyya Yiğit Kaya, Elif Melek, Yaşa Gül Mutlu, Hüseyin Saffet Beköz, Senem Maral, Leylagül Kaynar, Ömür Gökmen Sevindik

Correction to: Delphi consensus recommendations on treatment for advanced-stage marginal zone lymphoma in South Korea

Seok Jin Kim, Seug Yun Yoon, Sharon Chua, Hyeran Byun, Jiyoon Kim, Junice Ng

Keynote webinar | Spotlight on progress in colorectal cancer

  • Live
  • Webinar | 11-12-2025 | 18:00 (CET)

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Watch it live: Thursday 11 December 2025, 18:00-19:30 (CET)

Prof. Antoni Castells
Prof. Edward Giovannucci
Prof. Harpreet Wasan
Join the webinar
Webinar

Keynote webinar | Spotlight on functional neurological disorder

FND perplexes and frustrates patients and physicians alike. Limited knowledge and insufficient awareness delays diagnosis and treatment, and many patients feel misunderstood and stigmatized. How can you recognize FND and what are the treatment options?

Prof. Mark Edwards
Watch now
Video
Image Credits
Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Human brain illustration/© (M) CHRISTOPH BURGSTEDT / SCIENCE PHOTO LIBRARY / Getty Images