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Open Access 01-12-2023 | Ankylosing Spondylitis | Research article

Staged osteotomy in lateral position for the treatment of severe kyphotic deformity secondary to ankylosing spondylitis: a retrospective study

Authors: Zhengjun Hu, Rui Zhong, Deng Zhao, Fei Wang, Huaqiang Huang, Dengxu Jiang, Zhong Zhang, Yijian Liang

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2023

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Abstract

Background

Patients with severe kyphotic deformity (Cobb > 100°) secondary to ankylosing spondylitis (AS) occasionally cannot undergo corrective surgery in the prone position. Osteotomy in the lateral position might provide a possible solution. In this study, we aim to evaluate the clinical efficacy and safety of staged osteotomy in the lateral position for the treatment of AS-related severe kyphosis with a minimum of 2-year follow-up.

Methods

In total, 23 patients who underwent staged osteotomy in the lateral position from October 2015 to June 2017 were analyzed. In the first stage of surgery, all but one patient underwent a single-level Ponte osteotomy, which was followed by a pedicle subtraction osteotomy in the second stage. Mean follow-up was 30.8 ± 4.6 months. Global kyphosis (GK), thoracic kyphosis (TK), lumbar lordosis (LL), sagittal vertical axis (SVA), osteotomized vertebra intervertebral angle (OVI), chin-brow vertical angle (CBVA), Oswestry Disability Index (ODI) score and Scoliosis Research Society-22 Patient Questionnaire (SRS-22) were all compared pre- and postoperation.

Results

All kyphosis parameters were significantly improved (all P < 0.05). GK was corrected from 115.0 ± 13.4° to 46.5 ± 9.0° postoperatively, with a mean correction of 68.5°. SVA was improved from 21.2 ± 5.1 cm to 5.1 ± 1.8 cm postoperatively. After surgery, CBVA was adjusted from 64.1 ± 23.2° to 5.7 ± 10.6° and OVI was changed from 9.0 ± 2.7° to − 20.1 ± 5.6°. Both the ODI and SRS-22 showed substantial improvements (all P < 0.05). Four patients with mild complications were observed perioperatively.

Conclusion

In AS patients with severe kyphosis, satisfactory correction can be safely achieved with staged osteotomy in the lateral position, which can not only correct the sagittal imbalance of the spine with acceptable complications but also facilitate the placement of the intraoperative position.
Literature
1.
go back to reference Qian BP, Wang XH, Qiu Y, et al. The influence of closing-opening wedge osteotomy on sagittal balance in thoracolumbar kyphosis secondary to ankylosing spondylitis: a comparison with closing wedge osteotomy. Spine (Phila PA 1976). 2012;37(16):1415–23.CrossRefPubMed Qian BP, Wang XH, Qiu Y, et al. The influence of closing-opening wedge osteotomy on sagittal balance in thoracolumbar kyphosis secondary to ankylosing spondylitis: a comparison with closing wedge osteotomy. Spine (Phila PA 1976). 2012;37(16):1415–23.CrossRefPubMed
2.
go back to reference O’neill KR, Lenke LG, Bridwell KH, et al. Clinical and radiographic outcomes after 3-column osteotomies with 5-year follow-up. Spine (Phila Pa 1976). 2014;39(5):424–32.CrossRef O’neill KR, Lenke LG, Bridwell KH, et al. Clinical and radiographic outcomes after 3-column osteotomies with 5-year follow-up. Spine (Phila Pa 1976). 2014;39(5):424–32.CrossRef
3.
go back to reference Kim KT, Suk KS, Cho YJ, et al. Clinical outcome results of pedicle subtraction osteotomy in ankylosing spondylitis with kyphotic deformity. Spine. 2002;27:612–8.CrossRefPubMed Kim KT, Suk KS, Cho YJ, et al. Clinical outcome results of pedicle subtraction osteotomy in ankylosing spondylitis with kyphotic deformity. Spine. 2002;27:612–8.CrossRefPubMed
4.
go back to reference Debarge R, Demey G, Roussouly P. Radiological analysis of ankylosing spondylitis patients with severe kyphosis before and after pedicle subtraction osteotomy. Eur Spine J. 2010;19:65–70.CrossRefPubMed Debarge R, Demey G, Roussouly P. Radiological analysis of ankylosing spondylitis patients with severe kyphosis before and after pedicle subtraction osteotomy. Eur Spine J. 2010;19:65–70.CrossRefPubMed
5.
go back to reference Kiaer T, Gehrchen M. Transpedicular closed wedge osteotomy in ankylosing spondylitis: results of surgical treatment and prospective outcome analysis. Eur Spine J. 2010;19:57–64.CrossRefPubMed Kiaer T, Gehrchen M. Transpedicular closed wedge osteotomy in ankylosing spondylitis: results of surgical treatment and prospective outcome analysis. Eur Spine J. 2010;19:57–64.CrossRefPubMed
6.
go back to reference Qian BP, Qiu Y, Wang B, et al. Pedicle subtraction osteotomy through pseudarthrosis to correct thoracolumbar kyphotic deformity in advanced ankylosing spondylitis. Eur Spine J. 2012;21(4):711–8.CrossRefPubMed Qian BP, Qiu Y, Wang B, et al. Pedicle subtraction osteotomy through pseudarthrosis to correct thoracolumbar kyphotic deformity in advanced ankylosing spondylitis. Eur Spine J. 2012;21(4):711–8.CrossRefPubMed
7.
go back to reference Chang KW, Chen HC, Chen YY, et al. Sagittal translation in opening wedge osteotomy for the correction of thoracolumbar kyphotic deformity in ankylosing spondylitis. Spine (Phila Pa 1976). 2006;31(10):1137–42.CrossRefPubMed Chang KW, Chen HC, Chen YY, et al. Sagittal translation in opening wedge osteotomy for the correction of thoracolumbar kyphotic deformity in ankylosing spondylitis. Spine (Phila Pa 1976). 2006;31(10):1137–42.CrossRefPubMed
8.
go back to reference Chen IH, Chien JT, Yu TC. Transpedicular wedge osteotomy for correction of thoracolumbar kyphosis in ankylosing spondylitis: experience with 78 patients. Spine (Phila Pa 1976). 2001;26(16):E354–60.CrossRefPubMed Chen IH, Chien JT, Yu TC. Transpedicular wedge osteotomy for correction of thoracolumbar kyphosis in ankylosing spondylitis: experience with 78 patients. Spine (Phila Pa 1976). 2001;26(16):E354–60.CrossRefPubMed
9.
go back to reference Arun R, Dabke HV, Mehdian H. Comparison of three types of lumbar osteotomy for ankylosing spondylitis: a case series and evolution of a safe technique for instrumented reduction. Eur Spine J. 2011;20(12):2252–60.CrossRefPubMedPubMedCentral Arun R, Dabke HV, Mehdian H. Comparison of three types of lumbar osteotomy for ankylosing spondylitis: a case series and evolution of a safe technique for instrumented reduction. Eur Spine J. 2011;20(12):2252–60.CrossRefPubMedPubMedCentral
10.
go back to reference Liu ZJ, Qian BP, Qiu Y, et al. Does postoperative PI-LL mismatching affect surgical outcomes in thoracolumbar kyphosis associated with ankylosing spondylitis patients. Clin Neurol Neurosurg. 2018;169:71–6.CrossRefPubMed Liu ZJ, Qian BP, Qiu Y, et al. Does postoperative PI-LL mismatching affect surgical outcomes in thoracolumbar kyphosis associated with ankylosing spondylitis patients. Clin Neurol Neurosurg. 2018;169:71–6.CrossRefPubMed
11.
go back to reference Ponte A, Orlando G, Siccardi GL. The true ponte osteotomy: by the one who developed it. Spine Deform. 2018;6(1):2–11.CrossRefPubMed Ponte A, Orlando G, Siccardi GL. The true ponte osteotomy: by the one who developed it. Spine Deform. 2018;6(1):2–11.CrossRefPubMed
12.
go back to reference Debarge R, Demey G, Roussouly P. Sagittal balance analysis after pedicle subtraction osteotomy in ankylosing spondylitis. Eur Spine J. 2011;20(5):619–25.CrossRefPubMedPubMedCentral Debarge R, Demey G, Roussouly P. Sagittal balance analysis after pedicle subtraction osteotomy in ankylosing spondylitis. Eur Spine J. 2011;20(5):619–25.CrossRefPubMedPubMedCentral
13.
go back to reference Cho KJ, Bridwell KH, Lenke LG, et al. Comparison of Smith-Peterson versus pedicle subtraction osteotomy for the correction of fixed sagittal imbalance. Spine. 2005;30(18):2030–8.CrossRefPubMed Cho KJ, Bridwell KH, Lenke LG, et al. Comparison of Smith-Peterson versus pedicle subtraction osteotomy for the correction of fixed sagittal imbalance. Spine. 2005;30(18):2030–8.CrossRefPubMed
14.
go back to reference Liu H, Yang C, Zheng Z, et al. Comparison of Smith-Peterson osteotomy and pedicle subtraction osteotomy for the correction of thoracolumbar kyphotic deformity in ankylosing spondylitis: a systematic review and meta-analysis. Spine. 2015;40(8):570–9.CrossRefPubMed Liu H, Yang C, Zheng Z, et al. Comparison of Smith-Peterson osteotomy and pedicle subtraction osteotomy for the correction of thoracolumbar kyphotic deformity in ankylosing spondylitis: a systematic review and meta-analysis. Spine. 2015;40(8):570–9.CrossRefPubMed
15.
go back to reference Goie HS, Steven MM, van der Linden SM, et al. Evaluation of diagnostic criteria for ankylosing spondylitis: a comparison of the Rome, New York and modified New York criteria in patients with a positive clinical history screening test for ankylosing spondylitis. Br J Rheumatol. 1985;24:242–9.CrossRef Goie HS, Steven MM, van der Linden SM, et al. Evaluation of diagnostic criteria for ankylosing spondylitis: a comparison of the Rome, New York and modified New York criteria in patients with a positive clinical history screening test for ankylosing spondylitis. Br J Rheumatol. 1985;24:242–9.CrossRef
16.
go back to reference Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–68.CrossRefPubMed Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–68.CrossRefPubMed
17.
go back to reference Huang JC, Qian BP, Qiu Y, et al. What is the optimal postoperative sagittal alignment in ankylosing spondylitis patients with thoracolumbar kyphosis following one-level pedicle subtraction osteotomy? Spine J. 2020;20(5):765–75.CrossRefPubMed Huang JC, Qian BP, Qiu Y, et al. What is the optimal postoperative sagittal alignment in ankylosing spondylitis patients with thoracolumbar kyphosis following one-level pedicle subtraction osteotomy? Spine J. 2020;20(5):765–75.CrossRefPubMed
18.
go back to reference Song K, Su X, Zhang Y, et al. Optimal chin-brow vertical angle for sagittal visual fields in ankylosing spondylitis kyphosis. Eur Spine J. 2016;25(8):2596–604.CrossRefPubMed Song K, Su X, Zhang Y, et al. Optimal chin-brow vertical angle for sagittal visual fields in ankylosing spondylitis kyphosis. Eur Spine J. 2016;25(8):2596–604.CrossRefPubMed
19.
go back to reference Kim KT, Park DH, Lee SH, et al. Results of corrective osteotomy and treatment strategy for ankylosing spondylitis with kyphotic deformity. Clin Orthop Surg. 2015;7(3):330–6.CrossRefPubMedPubMedCentral Kim KT, Park DH, Lee SH, et al. Results of corrective osteotomy and treatment strategy for ankylosing spondylitis with kyphotic deformity. Clin Orthop Surg. 2015;7(3):330–6.CrossRefPubMedPubMedCentral
20.
go back to reference Asher M, Min Lai S, Burton D, et al. Scoliosis research society-22 patient questionnaire: responsiveness to change associated with surgical treatment. Spine (Phila Pa 1976). 2003;28(1):70–3.CrossRefPubMed Asher M, Min Lai S, Burton D, et al. Scoliosis research society-22 patient questionnaire: responsiveness to change associated with surgical treatment. Spine (Phila Pa 1976). 2003;28(1):70–3.CrossRefPubMed
21.
go back to reference Wang Y. History of spine osteotomy. Spinal Osteotomy. 2015;1(1):1–10. Wang Y. History of spine osteotomy. Spinal Osteotomy. 2015;1(1):1–10.
22.
go back to reference Stevens WR, Glazer PA, Kelley SD, et al. Ophthalmic complications after spinal surgery. Spine (Phila Pa 1976). 1997;22(12):1319–24.CrossRefPubMed Stevens WR, Glazer PA, Kelley SD, et al. Ophthalmic complications after spinal surgery. Spine (Phila Pa 1976). 1997;22(12):1319–24.CrossRefPubMed
23.
go back to reference Qian BP, Qiu Y, Ji ML, et al. Osteotomy for severe thoracolumbar kyphosis in advanced ankylosing spondylitis: skipping two-level pedicle subtraction osteotomy. Zhonghua Yi Xue Za Zhi. 2013;93(7):491–5.PubMed Qian BP, Qiu Y, Ji ML, et al. Osteotomy for severe thoracolumbar kyphosis in advanced ankylosing spondylitis: skipping two-level pedicle subtraction osteotomy. Zhonghua Yi Xue Za Zhi. 2013;93(7):491–5.PubMed
24.
go back to reference Liu C, Yu W, Zheng G, et al. The safe correction angle of osteotomy at T12 and L1 for ankylosing spondylitis kyphosis: patients with 2-level osteotomy. Clin Spine Surg. 2017;30:E942–7.CrossRefPubMed Liu C, Yu W, Zheng G, et al. The safe correction angle of osteotomy at T12 and L1 for ankylosing spondylitis kyphosis: patients with 2-level osteotomy. Clin Spine Surg. 2017;30:E942–7.CrossRefPubMed
25.
go back to reference Xu H, Zhang Y, Zhao Y, et al. Radiologic and clinical outcomes comparison between single- and two-level pedicle subtraction osteotomies in correcting ankylosing spondylitis kyphosis. Spine J. 2015;15:290–7.CrossRefPubMed Xu H, Zhang Y, Zhao Y, et al. Radiologic and clinical outcomes comparison between single- and two-level pedicle subtraction osteotomies in correcting ankylosing spondylitis kyphosis. Spine J. 2015;15:290–7.CrossRefPubMed
26.
go back to reference Zhong W, Chen Z, Zeng Y, et al. Two-level osteotomy for the corrective surgery of severe kyphosis from ankylosing spondylitis: a retrospective series. Spine (Phila Pa 1976). 2019;44(23):1638–46.CrossRefPubMed Zhong W, Chen Z, Zeng Y, et al. Two-level osteotomy for the corrective surgery of severe kyphosis from ankylosing spondylitis: a retrospective series. Spine (Phila Pa 1976). 2019;44(23):1638–46.CrossRefPubMed
27.
go back to reference Zhang HQ, Huang J, Guo CF, et al. Two-level pedicle subtraction osteotomy for severe thoracolumbar kyphotic deformity in ankylosing spondylitis. Eur Spine J. 2014;23:234–41.CrossRefPubMed Zhang HQ, Huang J, Guo CF, et al. Two-level pedicle subtraction osteotomy for severe thoracolumbar kyphotic deformity in ankylosing spondylitis. Eur Spine J. 2014;23:234–41.CrossRefPubMed
28.
go back to reference Chunguang Z, Limin L, Yueming S, et al. Two-stage vertebral column resection for severe and rigid scoliosis in patients with low body weight. Spine J. 2013;13:481–6.CrossRef Chunguang Z, Limin L, Yueming S, et al. Two-stage vertebral column resection for severe and rigid scoliosis in patients with low body weight. Spine J. 2013;13:481–6.CrossRef
29.
go back to reference Qian BP, Huang JC, Qiu Y, et al. Complications of spinal osteotomy for thoracolumbar kyphosis secondary to ankylosing spondylitis in 342 patients: incidence and risk factors. J Neurosurg Spine. 2018;30(1):91–8.CrossRefPubMed Qian BP, Huang JC, Qiu Y, et al. Complications of spinal osteotomy for thoracolumbar kyphosis secondary to ankylosing spondylitis in 342 patients: incidence and risk factors. J Neurosurg Spine. 2018;30(1):91–8.CrossRefPubMed
30.
go back to reference Weatherley C, Jaffray D, Terry A. Vascular complications associated with osteotomy in ankylosing spondylitis: a report of two cases. Spine (Phila Pa 1976). 1988;13(1):43–6.CrossRefPubMed Weatherley C, Jaffray D, Terry A. Vascular complications associated with osteotomy in ankylosing spondylitis: a report of two cases. Spine (Phila Pa 1976). 1988;13(1):43–6.CrossRefPubMed
31.
go back to reference Ji ML, Qian BP, Qiu Y, et al. Change of aortic length after closing-opening wedge osteotomy for patients with ankylosing spondylitis with thoracolumbar kyphosis: a computed tomographic study. Spine (Phila Pa 1976). 2013;38(22):E1361-7.CrossRefPubMed Ji ML, Qian BP, Qiu Y, et al. Change of aortic length after closing-opening wedge osteotomy for patients with ankylosing spondylitis with thoracolumbar kyphosis: a computed tomographic study. Spine (Phila Pa 1976). 2013;38(22):E1361-7.CrossRefPubMed
32.
go back to reference Kömürcü E, Kaymaz B, Adam G, et al. Safety and feasibility of lumbar spine for intralaminar screw fixation: a computed tomography-based morphometric study. Acta Orthop Traumatol Turc. 2015;49(5):522–9.PubMed Kömürcü E, Kaymaz B, Adam G, et al. Safety and feasibility of lumbar spine for intralaminar screw fixation: a computed tomography-based morphometric study. Acta Orthop Traumatol Turc. 2015;49(5):522–9.PubMed
33.
go back to reference Diao WY, Qian BP, Qiu Y, et al. Does the preoperative lumbar sagittal profile affect the selection of osteotomy level in pedicle subtraction osteotomy for thoracolumbar kyphosis secondary to ankylosing spondylitis. Clin Neurol Neurosurg. 2018;172:39–45.CrossRefPubMed Diao WY, Qian BP, Qiu Y, et al. Does the preoperative lumbar sagittal profile affect the selection of osteotomy level in pedicle subtraction osteotomy for thoracolumbar kyphosis secondary to ankylosing spondylitis. Clin Neurol Neurosurg. 2018;172:39–45.CrossRefPubMed
34.
go back to reference Koller H, Koller J, Mayer M, et al. Osteotomy in ankylosing spondylitis: where, how many, and how much. Eur Spine J. 2018;27(Suppl 1):S70-100.CrossRef Koller H, Koller J, Mayer M, et al. Osteotomy in ankylosing spondylitis: where, how many, and how much. Eur Spine J. 2018;27(Suppl 1):S70-100.CrossRef
35.
go back to reference Zheng GQ, Song K, Zhang YG, et al. Two level spinal osteotomy for severe thoracolumbar kyphosis in ankylosing spondylitis. Experience with 48 patients. Spine (Phila Pa 1976). 2014;39(13):1055–8.CrossRefPubMed Zheng GQ, Song K, Zhang YG, et al. Two level spinal osteotomy for severe thoracolumbar kyphosis in ankylosing spondylitis. Experience with 48 patients. Spine (Phila Pa 1976). 2014;39(13):1055–8.CrossRefPubMed
Metadata
Title
Staged osteotomy in lateral position for the treatment of severe kyphotic deformity secondary to ankylosing spondylitis: a retrospective study
Authors
Zhengjun Hu
Rui Zhong
Deng Zhao
Fei Wang
Huaqiang Huang
Dengxu Jiang
Zhong Zhang
Yijian Liang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2023
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-023-03884-5

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