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Critical Care
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Open Access 01-12-2024 | Anesthetics | Matters Arising

Reply to “volatile anaesthetics for ICU sedation: beyond hypnosis?”: A comment on “volatile anesthetics for lung- and diaphragm-protective sedation”

Authors: Lukas M. Müller-Wirtz, Marcus J. Schultz, Andreas Meiser

Published in: Critical Care | Issue 1/2024

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Excerpt

We appreciate the comment by Añón and colleagues on our review article, which contributes to the discussion of potential benefits of inhaled sedation beyond hypnosis [1]. One key purpose of review articles is to explore developing areas of research. As Añón and colleagues illustrate well in their comment, our article synthesizes established pharmacological properties of volatile anesthetics with early findings on their use in transitioning critically ill patients to spontaneous ventilation under inhaled sedation, aiming to evaluate potential lung and diaphragm protection benefits [2]. Our focus was on highlighting the importance of gathering detailed clinical data to explore feasibility of lung- and diaphragm-protective ventilation across various sedatives, including volatile anesthetics, rather than drawing any definitive conclusions. …
Literature
1.
Añón JM, Suarez-Sipmann F, Paz Escuela M, Perez-Lucendo A, García-Muñoz A. Volatile anaesthetics for ICU sedation: beyond hypnosis? Crit Care. 2024.
2.
Müller-Wirtz LM, O’Gara B, Gama de Abreu M, Schultz MJ, Beitler JR, Jerath A, et al. Volatile anesthetics for lung- and diaphragm-protective sedation. Crit Care. 2024;28:269.CrossRefPubMedPubMedCentral
3.
Meiser A, Volk T, Wallenborn J, Guenther U, Becher T, Bracht H, et al. Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial. Lancet Respir Med. 2021;9:1231–40.CrossRefPubMed
4.
Müller-Wirtz LM, Behne F, Kermad A, Wagenpfeil G, Schroeder M, Sessler DI, et al. Isoflurane promotes early spontaneous breathing in ventilated intensive care patients: a post hoc subgroup analysis of a randomized trial. Acta Anaesthesiol Scand. 2022;66:354–64.CrossRefPubMed
Metadata
Title
Reply to “volatile anaesthetics for ICU sedation: beyond hypnosis?”: A comment on “volatile anesthetics for lung- and diaphragm-protective sedation”
Authors
Lukas M. Müller-Wirtz
Marcus J. Schultz
Andreas Meiser
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2024
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-024-05182-w

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