Since its first edition was published in 1977, the American Joint Committee on Cancer (AJCC) has remained the authority on cancer staging for nearly all malignancies, including anal cancer.
1 Importantly, the AJCC staging system has created a common language for cancer risk stratification, allowing cancer care providers across the world to effectively communicate about tumor burden and treatment paradigms. Not only does the AJCC staging system provide prognostic information regarding the estimated survival for patients with cancer but it also plays a vital part in cancer research, including eligibility for practice-changing clinical trials. Additionally, AJCC cancer staging is a critical tool in cancer epidemiology and population health, as the structured framework and consistency allows for tracking of trends and comparison of data over time and across the globe. The AJCC staging system undergoes periodic revisions in order to ensure that the contemporary staging definitions reflect evolving practice patterns and survival outcomes for each primary disease site. …