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Acta Neurologica Belgica

An investigation on the effects of carbamazepine and sodium valproate on neuromuscular transmission

  • 01-06-2020
  • Original Article
Published in:
Authors
Halil Ay
Özlem Ethemoğlu
Published in
Acta Neurologica Belgica | Issue 3/2020

Abstract

The aim of this study was to investigate the effects of sodium valproate (SV) and carbamazepine (CBZ) on neuromuscular transmission using single-fibre electromyography (SFEMG) in patients with epilepsy. We performed SFEMG during the voluntary contraction of extensor digitorum communis muscle. 30 epileptic patients taking SV, 25 epileptic patients taking CBZ, and 25 age-matched healthy volunteers were included in the study. Mean jitter values (MCD) of subjects taking SV and CBZ were compared with normal controls. MCD values of subjects taking SV and CBZ were statistically significantly higher than those of control group. Review of the correlation between disease duration and MCD values of patients showed that MCD values were increased with the prolonged use of drugs, and thus, indicated a positive relationship between these two parameters. These results suggest that both SV and CBZ reduce neuromuscular transmission in patients without a neuromuscular junction disease.
Title
An investigation on the effects of carbamazepine and sodium valproate on neuromuscular transmission
Authors
Halil Ay
Özlem Ethemoğlu
Publication date
01-06-2020
Publisher
Springer International Publishing
Published in
Acta Neurologica Belgica / Issue 3/2020
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-017-0839-y
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