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Journal of Medical Case Reports
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Open Access 01-12-2025 | Case report

An infant inflammatory myofibroblastoma with TFG-ROS1 fusion: a case report

Authors: Hui Jiang, Junnan Jiang, Baidong Feng, Yaxian Yang, Qi Li, Bin Lian, Xiao Ding, Zhaodong Pan, Mingjian Huang, Zhaowen Pan, Jian Huang

Published in: Journal of Medical Case Reports | Issue 1/2025

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Abstract

Background

Inflammatory myofibroblastic tumors are extremely rare in the neck of infants, and pathological diagnosis may be challenging. Kinase fusions play an important role in the biology of many inflammatory myofibroblastic tumors, becoming an effective diagnostic method.

Case presentation

In this report, we present the case of an East Asian (Han Chinese) patient with rare infant inflammatory myofibroblastoma. DNA-based but not RNA-based next-generation sequencing was used to identify its targetable ROS1 fusions.

Conclusion

This case highlights the importance of simultaneously detecting DNA and RNA using next-generation sequencing in clinical practice.
Literature
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Metadata
Title
An infant inflammatory myofibroblastoma with TFG-ROS1 fusion: a case report
Authors
Hui Jiang
Junnan Jiang
Baidong Feng
Yaxian Yang
Qi Li
Bin Lian
Xiao Ding
Zhaodong Pan
Mingjian Huang
Zhaowen Pan
Jian Huang
Publication date
01-12-2025
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2025
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-025-05203-4

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