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Published in: Journal of Neurology 5/2023

21-01-2023 | Amyotrophic Lateral Sclerosis | Review

Physical activity as risk factor in amyotrophic lateral sclerosis: a systematic review and meta-analysis

Authors: Xiaoting Zheng, Shichan Wang, Jingxuan Huang, Junyu Lin, Tianmi Yang, Yi Xiao, Qirui Jiang, Rui Huang, Chunyu Li, Huifang Shang

Published in: Journal of Neurology | Issue 5/2023

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Abstract

Objective

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with rapid progression and high mortality. Physical activity (PA) has been identified as a major risk factor for ALS. However, the results across studies are still controversial. We aimed to explore the association between different types of PA and ALS.

Methods

The PubMed, EMBASE, Cochrane and Web of Science databases were systematically searched for case–control and cohort studies which explored the relationship between PA and ALS from inception to October 2022. The data were analyzed to generate a pooled effect and 95% confidence interval (CI).

Results

A total of 16,686 articles were included in the systematic search. After filtering, 28 studies from online database and 6 studies from references of relevant articles remained in the analysis. Individuals with a history of vigorous physical activity (OR 1.26, 95% CI 1.06–1.49), occupational-related activity (OR 1.14, 95% CI 1.04–1.25), leisure time activity (OR 1.08, 95% CI 1.04–1.12), unclassified PA (OR 1.05 95% CI 1.02–1.09) and professional athletes (SMR 5.23, 95% CI 2.67–10.25; SIR 2.54, 95% CI 1.37–4.69) were in higher risk of developing ALS. In contrast, sport-related activity (OR 0.97, 95% CI 0.76–1.26) was not associated with ALS.

Conclusions

Vigorous physical activity, occupational-related activity, leisure time activity, unclassified PA and professional athletes were associated with a higher risk of ALS, while sport-related activity showed no association with ALS. Our findings clarified the relation between different types of PA and ALS and provided some practicable advice for the lifestyle of high-risk populations.
Appendix
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Literature
1.
2.
go back to reference Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O et al (2011) Amyotrophic lateral sclerosis. Lancet 377(9769):942–955PubMedCrossRef Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O et al (2011) Amyotrophic lateral sclerosis. Lancet 377(9769):942–955PubMedCrossRef
3.
4.
go back to reference Jaiswal MK (2019) Riluzole and edaravone: a tale of two amyotrophic lateral sclerosis drugs. Med Res Rev 39(2):733–748PubMedCrossRef Jaiswal MK (2019) Riluzole and edaravone: a tale of two amyotrophic lateral sclerosis drugs. Med Res Rev 39(2):733–748PubMedCrossRef
5.
go back to reference Barp A, Gerardi F, Lizio A, Sansone VA, Lunetta C (2020) Emerging drugs for the treatment of amyotrophic lateral sclerosis: a focus on recent phase 2 trials. Expert Opin Emerg Drugs 25(2):145–164PubMedCrossRef Barp A, Gerardi F, Lizio A, Sansone VA, Lunetta C (2020) Emerging drugs for the treatment of amyotrophic lateral sclerosis: a focus on recent phase 2 trials. Expert Opin Emerg Drugs 25(2):145–164PubMedCrossRef
6.
go back to reference Larson TC, Kaye W, Mehta P, Horton DK (2018) Amyotrophic lateral sclerosis mortality in the United States, 2011–2014. Neuroepidemiology 51(1–2):96–103PubMedCrossRef Larson TC, Kaye W, Mehta P, Horton DK (2018) Amyotrophic lateral sclerosis mortality in the United States, 2011–2014. Neuroepidemiology 51(1–2):96–103PubMedCrossRef
7.
go back to reference Al-Chalabi A, Hardiman O (2013) The epidemiology of ALS: a conspiracy of genes, environment and time. Nat Rev Neurol 9(11):617–628PubMedCrossRef Al-Chalabi A, Hardiman O (2013) The epidemiology of ALS: a conspiracy of genes, environment and time. Nat Rev Neurol 9(11):617–628PubMedCrossRef
8.
9.
go back to reference Talbott EO, Malek AM, Lacomis D (2016) The epidemiology of amyotrophic lateral sclerosis. Handb Clin Neurol 138:225–238PubMedCrossRef Talbott EO, Malek AM, Lacomis D (2016) The epidemiology of amyotrophic lateral sclerosis. Handb Clin Neurol 138:225–238PubMedCrossRef
10.
go back to reference Breland AE Jr, Currier RD (1967) Multiple sclerosis and amyotrophic lateral sclerosis in mississippi. Neurology 17(10):1011–1016PubMedCrossRef Breland AE Jr, Currier RD (1967) Multiple sclerosis and amyotrophic lateral sclerosis in mississippi. Neurology 17(10):1011–1016PubMedCrossRef
11.
go back to reference Lacorte E, Ferrigno L, Leoncini E, Corbo M, Boccia S, Vanacore N (2016) Physical activity, and physical activity related to sports, leisure and occupational activity as risk factors for ALS: a systematic review. Neurosci Biobehav Rev 66:61–79PubMedCrossRef Lacorte E, Ferrigno L, Leoncini E, Corbo M, Boccia S, Vanacore N (2016) Physical activity, and physical activity related to sports, leisure and occupational activity as risk factors for ALS: a systematic review. Neurosci Biobehav Rev 66:61–79PubMedCrossRef
12.
go back to reference Savettieri G, Salemi G, Arcara A, Cassata M, Castiglione MG, Fierro B (1991) A case-control study of amyotrophic lateral sclerosis. Neuroepidemiology 10(5–6):242–245PubMedCrossRef Savettieri G, Salemi G, Arcara A, Cassata M, Castiglione MG, Fierro B (1991) A case-control study of amyotrophic lateral sclerosis. Neuroepidemiology 10(5–6):242–245PubMedCrossRef
13.
go back to reference Strickland D, Smith SA, Dolliff G, Goldman L, Roelofs RI (1996) Physical activity, trauma, and ALS: a case-control study. Acta Neurol Scand 94(1):45–50PubMedCrossRef Strickland D, Smith SA, Dolliff G, Goldman L, Roelofs RI (1996) Physical activity, trauma, and ALS: a case-control study. Acta Neurol Scand 94(1):45–50PubMedCrossRef
14.
go back to reference Beghi E, Logroscino G, Chiò A, Hardiman O, Millul A, Mitchell D et al (2010) Amyotrophic lateral sclerosis, physical exercise, trauma and sports: results of a population-based pilot case-control study. Amyotroph Lateral Scler 11(3):289–292PubMedPubMedCentralCrossRef Beghi E, Logroscino G, Chiò A, Hardiman O, Millul A, Mitchell D et al (2010) Amyotrophic lateral sclerosis, physical exercise, trauma and sports: results of a population-based pilot case-control study. Amyotroph Lateral Scler 11(3):289–292PubMedPubMedCentralCrossRef
15.
go back to reference Eaglehouse YL, Talbott EO, Chang Y, Kuller LH (2016) Participation in physical activity and risk for amyotrophic lateral sclerosis mortality among postmenopausal women. JAMA Neurol 73(3):329–336PubMedPubMedCentralCrossRef Eaglehouse YL, Talbott EO, Chang Y, Kuller LH (2016) Participation in physical activity and risk for amyotrophic lateral sclerosis mortality among postmenopausal women. JAMA Neurol 73(3):329–336PubMedPubMedCentralCrossRef
16.
go back to reference Visser AE, Rooney JPK, D’Ovidio F, Westeneng HJ, Vermeulen RCH, Beghi E et al (2018) Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 89(8):797–803PubMedCrossRef Visser AE, Rooney JPK, D’Ovidio F, Westeneng HJ, Vermeulen RCH, Beghi E et al (2018) Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 89(8):797–803PubMedCrossRef
17.
go back to reference Farrugia Wismayer M, Borg R, Farrugia Wismayer A, Bonavia K, Vella M, Pace A et al (2021) Occupation and amyotrophic lateral sclerosis risk: a case-control study in the isolated island population of Malta. Amyotroph Lateral Scler Frontotemporal Degener 22(7–8):528–534PubMedCrossRef Farrugia Wismayer M, Borg R, Farrugia Wismayer A, Bonavia K, Vella M, Pace A et al (2021) Occupation and amyotrophic lateral sclerosis risk: a case-control study in the isolated island population of Malta. Amyotroph Lateral Scler Frontotemporal Degener 22(7–8):528–534PubMedCrossRef
18.
go back to reference Chen GX, Douwes J, van den Berg LH, Glass B, McLean D, t Mannetje AM. (2022) Sports and trauma as risk factors for motor neurone disease: New Zealand case-control study. Acta Neurol Scand. 145(6):770–85 Chen GX, Douwes J, van den Berg LH, Glass B, McLean D, t Mannetje AM. (2022) Sports and trauma as risk factors for motor neurone disease: New Zealand case-control study. Acta Neurol Scand. 145(6):770–85
19.
go back to reference Gunnarsson LG, Bodin L, Söderfeldt B, Axelson O (1992) A case-control study of motor neurone disease: its relation to heritability, and occupational exposures, particularly to solvents. Br J Ind Med 49(11):791–798PubMedPubMedCentral Gunnarsson LG, Bodin L, Söderfeldt B, Axelson O (1992) A case-control study of motor neurone disease: its relation to heritability, and occupational exposures, particularly to solvents. Br J Ind Med 49(11):791–798PubMedPubMedCentral
20.
go back to reference Pupillo E, Messina P, Giussani G, Logroscino G, Zoccolella S, Chiò A et al (2014) Physical activity and amyotrophic lateral sclerosis: a European population-based case-control study. Ann Neurol 75(5):708–716PubMedCrossRef Pupillo E, Messina P, Giussani G, Logroscino G, Zoccolella S, Chiò A et al (2014) Physical activity and amyotrophic lateral sclerosis: a European population-based case-control study. Ann Neurol 75(5):708–716PubMedCrossRef
21.
go back to reference Gallo V, Vanacore N, Bueno-de-Mesquita HB, Vermeulen R, Brayne C, Pearce N et al (2016) Physical activity and risk of amyotrophic lateral sclerosis in a prospective cohort study. Eur J Epidemiol 31(3):255–266PubMedPubMedCentralCrossRef Gallo V, Vanacore N, Bueno-de-Mesquita HB, Vermeulen R, Brayne C, Pearce N et al (2016) Physical activity and risk of amyotrophic lateral sclerosis in a prospective cohort study. Eur J Epidemiol 31(3):255–266PubMedPubMedCentralCrossRef
22.
go back to reference Valenti M, Pontieri FE, Conti F, Altobelli E, Manzoni T, Frati L (2005) Amyotrophic lateral sclerosis and sports: a case-control study. Eur J Neurol 12(3):223–225PubMedCrossRef Valenti M, Pontieri FE, Conti F, Altobelli E, Manzoni T, Frati L (2005) Amyotrophic lateral sclerosis and sports: a case-control study. Eur J Neurol 12(3):223–225PubMedCrossRef
23.
go back to reference Veldink JH, Kalmijn S, Groeneveld GJ, Titulaer MJ, Wokke JHJ, Van Den Berg LH (2005) Physical activity and the association with sporadic ALS. Neurology 64(2):241–245PubMedCrossRef Veldink JH, Kalmijn S, Groeneveld GJ, Titulaer MJ, Wokke JHJ, Van Den Berg LH (2005) Physical activity and the association with sporadic ALS. Neurology 64(2):241–245PubMedCrossRef
24.
go back to reference Vanacore N, Cocco P, Fadda D, Dosemeci M (2010) Job strain, hypoxia and risk of amyotrophic lateral sclerosis: results from a death certificate study. Amyotroph Lateral Scler 11(5):430–434PubMedCrossRef Vanacore N, Cocco P, Fadda D, Dosemeci M (2010) Job strain, hypoxia and risk of amyotrophic lateral sclerosis: results from a death certificate study. Amyotroph Lateral Scler 11(5):430–434PubMedCrossRef
25.
go back to reference Korner S, Kammeyer J, Zapf A, Kuzma-Kozakiewicz M, Piotrkiewicz M, Kuraszkiewicz B et al (2019) Influence of environment and lifestyle on incidence and progress of amyotrophic lateral sclerosis in a German ALS population. Aging Dis 10(2):205–216PubMedPubMedCentralCrossRef Korner S, Kammeyer J, Zapf A, Kuzma-Kozakiewicz M, Piotrkiewicz M, Kuraszkiewicz B et al (2019) Influence of environment and lifestyle on incidence and progress of amyotrophic lateral sclerosis in a German ALS population. Aging Dis 10(2):205–216PubMedPubMedCentralCrossRef
26.
go back to reference Filippini T, Fiore M, Tesauro M, Malagoli C, Consonni M, Violi F et al (2020) Clinical and lifestyle factors and risk of amyotrophic lateral sclerosis: a population-based case-control study. Int J Env Res Public Health 17(3):857CrossRef Filippini T, Fiore M, Tesauro M, Malagoli C, Consonni M, Violi F et al (2020) Clinical and lifestyle factors and risk of amyotrophic lateral sclerosis: a population-based case-control study. Int J Env Res Public Health 17(3):857CrossRef
27.
go back to reference Huisman MHB, Seelen M, De Jong SW, Dorresteijn KRIS, Van Doormaal PTC, Van Der Kooi AJ et al (2013) Lifetime physical activity and the risk of amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 84(9):976–981PubMedCrossRef Huisman MHB, Seelen M, De Jong SW, Dorresteijn KRIS, Van Doormaal PTC, Van Der Kooi AJ et al (2013) Lifetime physical activity and the risk of amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 84(9):976–981PubMedCrossRef
28.
go back to reference Lian L, Liu M, Cui L, Guan Y, Liu T, Cui B et al (2019) Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control study of ALS in China. J Clin Neurosci 66:12–18PubMedCrossRef Lian L, Liu M, Cui L, Guan Y, Liu T, Cui B et al (2019) Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control study of ALS in China. J Clin Neurosci 66:12–18PubMedCrossRef
29.
go back to reference Belli S, Vanacore N (2005) Proportionate mortality of Italian soccer players: is amyotrophic lateral sclerosis an occupational disease? Eur J Epidemiol 20(3):237–242PubMedCrossRef Belli S, Vanacore N (2005) Proportionate mortality of Italian soccer players: is amyotrophic lateral sclerosis an occupational disease? Eur J Epidemiol 20(3):237–242PubMedCrossRef
30.
go back to reference Taioli E (2007) All causes mortality in male professional soccer players. Eur J Pub Health 17(6):600–604CrossRef Taioli E (2007) All causes mortality in male professional soccer players. Eur J Pub Health 17(6):600–604CrossRef
31.
go back to reference Chio A, Calvo A, Dossena M, Ghiglione P, Mutani R, Mora G (2009) ALS in Italian professional soccer players: the risk is still present and could be soccer-specific. Amyotroph Lateral Scler 10(4):205–209PubMedCrossRef Chio A, Calvo A, Dossena M, Ghiglione P, Mutani R, Mora G (2009) ALS in Italian professional soccer players: the risk is still present and could be soccer-specific. Amyotroph Lateral Scler 10(4):205–209PubMedCrossRef
32.
go back to reference Lehman EJ, Hein MJ, Baron SL, Gersic CM (2012) Neurodegenerative causes of death among retired National football league players. Neurology 79(19):1970–1974PubMedPubMedCentralCrossRef Lehman EJ, Hein MJ, Baron SL, Gersic CM (2012) Neurodegenerative causes of death among retired National football league players. Neurology 79(19):1970–1974PubMedPubMedCentralCrossRef
33.
go back to reference Pupillo E, Bianchi E, Vanacore N, Montalto C, Ricca G, Della Cuna FSR et al (2020) Increased risk and early onset of ALS in professional players from Italian soccer teams. Amyotroph Lateral Sclerosis Frontotemporal Degener 21(5–6):403–409CrossRef Pupillo E, Bianchi E, Vanacore N, Montalto C, Ricca G, Della Cuna FSR et al (2020) Increased risk and early onset of ALS in professional players from Italian soccer teams. Amyotroph Lateral Sclerosis Frontotemporal Degener 21(5–6):403–409CrossRef
34.
go back to reference Daneshvar DH, Mez J, Alosco ML, Baucom ZH, Mahar I, Baugh CM et al (2021) Incidence of and mortality from amyotrophic lateral sclerosis in National football league athletes. JAMA Netw Open 4(12):e2138801PubMedPubMedCentralCrossRef Daneshvar DH, Mez J, Alosco ML, Baucom ZH, Mahar I, Baugh CM et al (2021) Incidence of and mortality from amyotrophic lateral sclerosis in National football league athletes. JAMA Netw Open 4(12):e2138801PubMedPubMedCentralCrossRef
35.
go back to reference Harwood CA, Westgate K, Gunstone S, Brage S, Wareham NJ, McDermott CJ et al (2016) Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis? Amyotroph Lateral Scler Frontotemporal Degener 17(5–6):377–384PubMedPubMedCentralCrossRef Harwood CA, Westgate K, Gunstone S, Brage S, Wareham NJ, McDermott CJ et al (2016) Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis? Amyotroph Lateral Scler Frontotemporal Degener 17(5–6):377–384PubMedPubMedCentralCrossRef
36.
go back to reference Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71PubMedPubMedCentralCrossRef Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71PubMedPubMedCentralCrossRef
37.
go back to reference Ainsworth BE, Haskell WL, Leon AS, Jacobs DR Jr, Montoye HJ, Sallis JF et al (1993) Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 25(1):71–80PubMedCrossRef Ainsworth BE, Haskell WL, Leon AS, Jacobs DR Jr, Montoye HJ, Sallis JF et al (1993) Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 25(1):71–80PubMedCrossRef
38.
go back to reference Julious SA, Nicholl J, George S (2001) Why do we continue to use standardized mortality ratios for small area comparisons? J Public Health Med 23(1):40–46PubMedCrossRef Julious SA, Nicholl J, George S (2001) Why do we continue to use standardized mortality ratios for small area comparisons? J Public Health Med 23(1):40–46PubMedCrossRef
39.
go back to reference Vujic I, Gandini S, Stanganelli I, Fierro MT, Rappersberger K, Sibilia M et al (2020) A meta-analysis of melanoma risk in industrial workers. Melanoma Res 30(3):286–296PubMedCrossRef Vujic I, Gandini S, Stanganelli I, Fierro MT, Rappersberger K, Sibilia M et al (2020) A meta-analysis of melanoma risk in industrial workers. Melanoma Res 30(3):286–296PubMedCrossRef
40.
go back to reference Hartung J, Knapp G (2001) On tests of the overall treatment effect in meta-analysis with normally distributed responses. Stat Med 20(12):1771–1782PubMedCrossRef Hartung J, Knapp G (2001) On tests of the overall treatment effect in meta-analysis with normally distributed responses. Stat Med 20(12):1771–1782PubMedCrossRef
41.
go back to reference Hartung J, Knapp G (2001) A refined method for the meta-analysis of controlled clinical trials with binary outcome. Stat Med 20(24):3875–3889PubMedCrossRef Hartung J, Knapp G (2001) A refined method for the meta-analysis of controlled clinical trials with binary outcome. Stat Med 20(24):3875–3889PubMedCrossRef
42.
go back to reference Felmus MT, Patten BM, Swanke L (1976) Antecedent events in amyotrophic lateral sclerosis. Neurology 26(2):167–172PubMedCrossRef Felmus MT, Patten BM, Swanke L (1976) Antecedent events in amyotrophic lateral sclerosis. Neurology 26(2):167–172PubMedCrossRef
43.
go back to reference Provinciali L, Giovagnoli AR (1990) Antecedent events in amyotrophic lateral sclerosis: do they influence clinical onset and progression? Neuroepidemiology 9(5):255–262PubMedCrossRef Provinciali L, Giovagnoli AR (1990) Antecedent events in amyotrophic lateral sclerosis: do they influence clinical onset and progression? Neuroepidemiology 9(5):255–262PubMedCrossRef
44.
go back to reference Longstreth WT Jr, McGuire V, Koepsell TD, Wang Y, Van Belle G (1998) Risk of amyotrophic lateral sclerosis and history of physical activity: a population-based case-control study. Arch Neurol 55(2):201–206PubMedCrossRef Longstreth WT Jr, McGuire V, Koepsell TD, Wang Y, Van Belle G (1998) Risk of amyotrophic lateral sclerosis and history of physical activity: a population-based case-control study. Arch Neurol 55(2):201–206PubMedCrossRef
45.
go back to reference Okamoto K, Kihira T, Kondo T, Kobashi G, Washio M, Sasaki S et al (2009) Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan. Ann Epidemiol 19(6):359–364PubMedCrossRef Okamoto K, Kihira T, Kondo T, Kobashi G, Washio M, Sasaki S et al (2009) Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan. Ann Epidemiol 19(6):359–364PubMedCrossRef
46.
go back to reference Yu Y, Su F-C, Callaghan BC, Goutman SA, Batterman SA, Feldman EL (2014) Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control study of ALS in michigan. PLoS ONE 9(6):e101186PubMedPubMedCentralCrossRef Yu Y, Su F-C, Callaghan BC, Goutman SA, Batterman SA, Feldman EL (2014) Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control study of ALS in michigan. PLoS ONE 9(6):e101186PubMedPubMedCentralCrossRef
47.
go back to reference Diekmann K, Kuzma-Kozakiewicz M, Piotrkiewicz M, Gromicho M, Grosskreutz J, Andersen PM et al (2020) Impact of comorbidities and co-medication on disease onset and progression in a large German ALS patient group. J Neurol 267(7):2130–2141PubMedCrossRef Diekmann K, Kuzma-Kozakiewicz M, Piotrkiewicz M, Gromicho M, Grosskreutz J, Andersen PM et al (2020) Impact of comorbidities and co-medication on disease onset and progression in a large German ALS patient group. J Neurol 267(7):2130–2141PubMedCrossRef
48.
go back to reference Rosenbohm A, Peter R, Dorst J, Kassubek J, Rothenbacher D, Nagel G et al (2021) Life course of physical activity and risk and prognosis of amyotrophic lateral sclerosis in a German ALS registry. Neurology 97(19):E1955–E1963PubMedCrossRef Rosenbohm A, Peter R, Dorst J, Kassubek J, Rothenbacher D, Nagel G et al (2021) Life course of physical activity and risk and prognosis of amyotrophic lateral sclerosis in a German ALS registry. Neurology 97(19):E1955–E1963PubMedCrossRef
49.
go back to reference Phelps A, Alosco ML, Baucom Z, Hartlage K, Palmisano JN, Weuve J et al (2022) Association of playing college American football with long-term health outcomes and mortality. JAMA Netw Open 5(4):E228775PubMedPubMedCentralCrossRef Phelps A, Alosco ML, Baucom Z, Hartlage K, Palmisano JN, Weuve J et al (2022) Association of playing college American football with long-term health outcomes and mortality. JAMA Netw Open 5(4):E228775PubMedPubMedCentralCrossRef
50.
go back to reference Orhant E, Carling C, Chapellier J-F, Marchand J-L, Pradat P-F, Elbaz A et al (2022) A retrospective analysis of all-cause and cause-specific mortality rates in French male professional footballers. Scand J Med Sci Sports 32(9):1389–1399PubMedCrossRef Orhant E, Carling C, Chapellier J-F, Marchand J-L, Pradat P-F, Elbaz A et al (2022) A retrospective analysis of all-cause and cause-specific mortality rates in French male professional footballers. Scand J Med Sci Sports 32(9):1389–1399PubMedCrossRef
51.
go back to reference Savica R, Parisi JE, Wold LE, Josephs KA, Ahlskog JE (2012) High school football and risk of neurodegeneration: a community-based study. Mayo Clin Proc 87(4):335–340PubMedPubMedCentralCrossRef Savica R, Parisi JE, Wold LE, Josephs KA, Ahlskog JE (2012) High school football and risk of neurodegeneration: a community-based study. Mayo Clin Proc 87(4):335–340PubMedPubMedCentralCrossRef
52.
go back to reference Russell ER, Mackay DF, Stewart K, MacLean JA, Pell JP, Stewart W (2021) Association of field position and career length with risk of neurodegenerative disease in male former professional soccer players. JAMA Neurol 78(9):1057–1063PubMedCrossRef Russell ER, Mackay DF, Stewart K, MacLean JA, Pell JP, Stewart W (2021) Association of field position and career length with risk of neurodegenerative disease in male former professional soccer players. JAMA Neurol 78(9):1057–1063PubMedCrossRef
53.
go back to reference Fang F, Hållmarker U, James S, Ingre C, Michaëlsson K, Ahlbom A, et al. (2016) Amyotrophic lateral sclerosis among cross-country skiers in Sweden. Eur J Epidemiol 31(3):247-253PubMedCrossRef Fang F, Hållmarker U, James S, Ingre C, Michaëlsson K, Ahlbom A, et al. (2016) Amyotrophic lateral sclerosis among cross-country skiers in Sweden. Eur J Epidemiol 31(3):247-253PubMedCrossRef
54.
go back to reference Armon C (2003) An evidence-based medicine approach to the evaluation of the role of exogenous risk factors in sporadic amyotrophic lateral sclerosis. Neuroepidemiology 22(4):217–228PubMedCrossRef Armon C (2003) An evidence-based medicine approach to the evaluation of the role of exogenous risk factors in sporadic amyotrophic lateral sclerosis. Neuroepidemiology 22(4):217–228PubMedCrossRef
55.
go back to reference Harwood CA, McDermott CJ, Shaw PJ (2009) Physical activity as an exogenous risk factor in motor neuron disease (MND): a review of the evidence. Amyotroph Lateral Scler 10(4):191–204PubMedCrossRef Harwood CA, McDermott CJ, Shaw PJ (2009) Physical activity as an exogenous risk factor in motor neuron disease (MND): a review of the evidence. Amyotroph Lateral Scler 10(4):191–204PubMedCrossRef
56.
go back to reference Hamidou B, Couratier P, Besançon C, Nicol M, Preux PM, Marin B (2014) Epidemiological evidence that physical activity is not a risk factor for ALS. Eur J Epidemiol 29(7):459–475PubMedCrossRef Hamidou B, Couratier P, Besançon C, Nicol M, Preux PM, Marin B (2014) Epidemiological evidence that physical activity is not a risk factor for ALS. Eur J Epidemiol 29(7):459–475PubMedCrossRef
57.
go back to reference Wang MD, Little J, Gomes J, Cashman NR, Krewski D (2017) Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. Neurotoxicology 61:101–130PubMedCrossRef Wang MD, Little J, Gomes J, Cashman NR, Krewski D (2017) Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. Neurotoxicology 61:101–130PubMedCrossRef
58.
go back to reference Narita Y (2019) A brief review on recent epidemiologic literature and risk factors of amyotrophic lateral sclerosis. Brain Nerve = Shinkei Kenkyu no Shinpo 71(11):1129–1137PubMed Narita Y (2019) A brief review on recent epidemiologic literature and risk factors of amyotrophic lateral sclerosis. Brain Nerve = Shinkei Kenkyu no Shinpo 71(11):1129–1137PubMed
59.
go back to reference Ingre C, Roos PM, Piehl F, Kamel F, Fang F (2015) Risk factors for amyotrophic lateral sclerosis. Clin Epidemiol 7:181–193PubMedPubMedCentral Ingre C, Roos PM, Piehl F, Kamel F, Fang F (2015) Risk factors for amyotrophic lateral sclerosis. Clin Epidemiol 7:181–193PubMedPubMedCentral
60.
go back to reference Gunnarsson L-G, Bodin L (2018) Amyotrophic lateral sclerosis and occupational exposures: a systematic literature review and meta-analyses. Int J Env Res Public Health 15(11):2371CrossRef Gunnarsson L-G, Bodin L (2018) Amyotrophic lateral sclerosis and occupational exposures: a systematic literature review and meta-analyses. Int J Env Res Public Health 15(11):2371CrossRef
61.
go back to reference Westeneng H-J, van Veenhuijzen K, van der Spek RA, Peters S, Visser AE, van Rheenen W et al (2021) Associations between lifestyle and amyotrophic lateral sclerosis stratified by C9orf72 genotype: a longitudinal, population-based, case-control study. Lancet Neurol 20(5):373–384PubMedCrossRef Westeneng H-J, van Veenhuijzen K, van der Spek RA, Peters S, Visser AE, van Rheenen W et al (2021) Associations between lifestyle and amyotrophic lateral sclerosis stratified by C9orf72 genotype: a longitudinal, population-based, case-control study. Lancet Neurol 20(5):373–384PubMedCrossRef
62.
go back to reference Kirkinezos IG, Hernandez D, Bradley WG, Moraes CT (2003) Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis. Ann Neurol 53(6):804–807PubMedCrossRef Kirkinezos IG, Hernandez D, Bradley WG, Moraes CT (2003) Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis. Ann Neurol 53(6):804–807PubMedCrossRef
63.
go back to reference Liebetanz D, Hagemann K, von Lewinski F, Kahler E, Paulus W (2004) Extensive exercise is not harmful in amyotrophic lateral sclerosis. Eur J Neurosci 20(11):3115–3120PubMedCrossRef Liebetanz D, Hagemann K, von Lewinski F, Kahler E, Paulus W (2004) Extensive exercise is not harmful in amyotrophic lateral sclerosis. Eur J Neurosci 20(11):3115–3120PubMedCrossRef
64.
go back to reference Carreras I, Yuruker S, Aytan N, Hossain L, Choi J-K, Jenkins BG et al (2010) Moderate exercise delays the motor performance decline in a transgenic model of ALS. Brain Res 1313:192–201PubMedCrossRef Carreras I, Yuruker S, Aytan N, Hossain L, Choi J-K, Jenkins BG et al (2010) Moderate exercise delays the motor performance decline in a transgenic model of ALS. Brain Res 1313:192–201PubMedCrossRef
65.
go back to reference Bandres-Ciga S, Noyce AJ, Hemani G, Nicolas A, Calvo A, Mora G et al (2019) Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis. Ann Neurol 85(4):470–481PubMedPubMedCentralCrossRef Bandres-Ciga S, Noyce AJ, Hemani G, Nicolas A, Calvo A, Mora G et al (2019) Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis. Ann Neurol 85(4):470–481PubMedPubMedCentralCrossRef
66.
go back to reference Julian TH, Glascow N, Barry ADF, Moll T, Harvey C, Klimentidis YC et al (2021) Physical exercise is a risk factor for amyotrophic lateral sclerosis: convergent evidence from mendelian randomisation, transcriptomics and risk genotypes. EBioMedicine 68:103397PubMedPubMedCentralCrossRef Julian TH, Glascow N, Barry ADF, Moll T, Harvey C, Klimentidis YC et al (2021) Physical exercise is a risk factor for amyotrophic lateral sclerosis: convergent evidence from mendelian randomisation, transcriptomics and risk genotypes. EBioMedicine 68:103397PubMedPubMedCentralCrossRef
67.
go back to reference Wu P-F, Lu H, Zhou X, Liang X, Li R, Zhang W et al (2021) Assessment of causal effects of physical activity on neurodegenerative diseases: a Mendelian randomization study. J Sport Health Sci 10(4):454–461PubMedPubMedCentralCrossRef Wu P-F, Lu H, Zhou X, Liang X, Li R, Zhang W et al (2021) Assessment of causal effects of physical activity on neurodegenerative diseases: a Mendelian randomization study. J Sport Health Sci 10(4):454–461PubMedPubMedCentralCrossRef
68.
go back to reference Zhang G, Zhang L, Tang L, Xia K, Huang T, Fan D (2021) Physical activity and amyotrophic lateral sclerosis: a mendelian randomization study. Neurobiol Aging 105:374.e1-e4PubMedCrossRef Zhang G, Zhang L, Tang L, Xia K, Huang T, Fan D (2021) Physical activity and amyotrophic lateral sclerosis: a mendelian randomization study. Neurobiol Aging 105:374.e1-e4PubMedCrossRef
Metadata
Title
Physical activity as risk factor in amyotrophic lateral sclerosis: a systematic review and meta-analysis
Authors
Xiaoting Zheng
Shichan Wang
Jingxuan Huang
Junyu Lin
Tianmi Yang
Yi Xiao
Qirui Jiang
Rui Huang
Chunyu Li
Huifang Shang
Publication date
21-01-2023
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 5/2023
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-022-11555-4

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