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Aberrant protein aggregation in amyotrophic lateral sclerosis

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Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal disease. As its pathological mechanisms are not well understood, there are no efficient therapeutics for it at present. While it is highly heterogenous both etiologically and clinically, it has a common salient hallmark, i.e., aberrant protein aggregation (APA). The upstream pathogenesis and the downstream effects of APA in ALS are sophisticated and the investigation of this pathology would be of consequence for understanding ALS. In this paper, the pathomechanism of APA in ALS and the candidate treatment strategies for it are discussed.
Title
Aberrant protein aggregation in amyotrophic lateral sclerosis
Authors
Huaixiu Wang
Rong Zeng
Publication date
13-06-2024
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 8/2024
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-024-12485-z
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