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Current Hypertension Reports

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17-02-2023 | Amiloride | Inflammation and Cardiovascular Diseases (A Kirabo, Section Editor)

Salt Taste and Salt Sensitive Hypertension in HIV

Authors: Sepiso K. Masenga, Leta Pilic, Annet Kirabo

Published in: Current Hypertension Reports | Issue 3/2023

Abstract

Purpose of Review

To provide a summary of current literature and propose potential mechanistic models to help us understand the role of HIV infection/antiretroviral therapy (ART), salt taste sensitivity (STS), and salt sensitivity of blood pressure (SSBP) in hypertension development.

Recent Findings

The epithelial sodium channel (ENaC) is the main protein/sodium channel for recognizing Na + in the tongue and mediates preference to low-medium salt concentrations in animals and humans. Considering the pressor response to oral salt in individuals with SSBP, poor STS may worsen blood pressure. Specific genetic variants in ENaC are linked to salt taste perception and hypertension. HIV infection, some ART, and specific antihypertensive drugs are associated with reduced STS and an increased liking for salty foods.

Summary

Persons with HIV (PWH) on ART may have a decreased STS and are at a higher risk of developing salt-sensitive hypertension. Inflammation mediated by dietary salt is one of the drivers of poor STS and salt-sensitive hypertension among PWH.

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Title: Salt Taste and Salt Sensitive Hypertension in HIV
Authors: Sepiso K. Masenga
Leta Pilic
Annet Kirabo
Publication date: 17-02-2023
Publisher: Springer US
Keywords: Amiloride
Human Immunodeficiency Virus
Hypertension
Hypertension
Published in: Current Hypertension Reports / Issue 3/2023
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-023-01236-6

Webinar | 08-11-2023 | 18:00 (CET)

Keynote Webinar | Spotlight on Diet and Diabetes

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An expert-led symposium exploring the prevention and management of type 2 diabetes through dietary interventions. Highlights include discussion of the recent EASD guidelines, therapeutic diets, food types and processing, plus psychological factors that influence patient success, and the drivers of healthy eating and diabetes control.

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Keynote Webinar | Spotlight on Diet and Diabetes

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Keynote Webinar | Spotlight on Diet and Diabetes