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Alzheimer's Research & Therapy

Issue 1/2025

Content (163 Articles)

Plasma phospho-tau217 as a predictive biomarker for Alzheimer’s disease in a large south American cohort

Neetesh Pandey, Zikun Yang, Basilio Cieza, Dolly Reyes-Dumeyer, Min Suk Kang, Rosa Montesinos, Marcio Soto-Añari, Nilton Custodio, Lawrence S. Honig, Giuseppe Tosto

Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease

Zehu Sheng, Lanyang Wang, Ming Chen, Fuxin Zhong, Shijing Wu, Shuyu Liang, Jiaqi Song, Lihua Chen, Yingxi Chen, Shiyu Chen, Weihua Yu, Yang Lü

Transcriptomic predictors of rapid progression from mild cognitive impairment to Alzheimer's disease

Yi-Long Huang, Tsung-Hsien Tsai, Zhao-Qing Shen, Yun-Hsuan Chan, Chih-Wei Tu, Chien-Yi Tung, Pei-Ning Wang, Ting-Fen Tsai

The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation

Mark Bitsch Vestergaard, Aftab Bakhtiari, Merete Osler, Erik Lykke Mortensen, Ulrich Lindberg, Ian Law, Martin Lauritzen, Krisztina Benedek, Henrik Bo Wiberg Larsson

Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease

Phoebe Valdes, Andrew B. Caldwell, Qing Liu, Michael Q. Fitzgerald, Srinivasan Ramachandran, Celeste M. Karch, Sarah Adams, Ricardo Allegri, Aki Araki, Nicolas Barthelemy, Randall Bateman, Jacob Bechara, Tammie Benzinger, Sarah Berman, Courtney Bodge, Susan Brandon, William Bill Brooks, Jared Brosch, Jill Buck, Virginia Buckles, Kathleen Carter, Lisa Cash, Charlie Chen, Jasmeer Chhatwal, Patricio Chrem Mendez, Jasmin Chua, Helena Chui, Laura Courtney, Carlos Cruchaga, Gregory S. Day, Chrismary DeLaCruz, Darcy Denner, Anna Diffenbacher, Aylin Dincer, Tamara Donahue, Jane Douglas, Duc Duong, Noelia Egido, Bianca Esposito, Anne Fagan, Marty Farlow, Becca Feldman, Colleen Fitzpatrick, Shaney Flores, Nick Fox, Erin Franklin, Nelly Joseph-Mathurin, Hisako Fujii, Samantha Gardener, Bernardino Ghetti, Alison Goate, Sarah Goldberg, Jill Goldman, Alyssa Gonzalez, Brian Gordon, Susanne Gräber-Sultan, Neill Graff-Radford, Morgan Graham, Julia Gray, Emily Gremminger, Miguel Grilo, Alex Groves, Christian Haass, Lisa Häsler, Jason Hassenstab, Cortaiga Hellm, Elizabeth Herries, Laura Hoechst-Swisher, Anna Hofmann, David Holtzman, Russ Hornbeck, Yakushev Igor, Ryoko Ihara, Takeshi Ikeuchi, Snezana Ikonomovic, Kenji Ishii, Clifford Jack, Gina Jerome, Erik Johnson, Mathias Jucker, Stephan Käser, Kensaku Kasuga, Sarah Keefe, William Klunk, Robert Koeppe, Deb Koudelis, Elke Kuder-Buletta, Christoph Laske, Allan Levey, Johannes Levin, Yan Li, Oscar Lopez, Jacob Marsh, Ralph Martins, Neal Scott Mason, Colin Masters, Kwasi Mawuenyega, Austin McCullough, Eric McDade, Arlene Mejia, Estrella Morenas-Rodriguez, John Morris, James Mountz, Cath Mummery, Neelesh Nadkarni, Akemi Nagamatsu, Katie Neimeyer, Yoshiki Niimi, James Noble, Joanne Norton, Brigitte Nuscher, Ulricke Obermüller, Antoinette O’Connor, Riddhi Patira, Richard Perrin, Lingyan Ping, Oliver Preische, Alan Renton, John Ringman, Stephen Salloway, Peter Schofield, Michio Senda, Nicholas T. Seyfried, Kristine Shady, Hiroyuki Shimada, Wendy Sigurdson, Jennifer Smith, Lori Smith, Beth Snitz, Hamid Sohrabi, Sochenda Stephens, Kevin Taddei, Sarah Thompson, Jonathan Vöglein, Peter Wang, Qing Wang, Elise Weamer, Chengjie Xiong, Jinbin Xu, Xiong Xu, Douglas R. Galasko, Shauna H. Yuan, Steven L. Wagner, Shankar Subramaniam

Benchmarking Alzheimer’s disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies

Eftychia Bellou, Woori Kim, Ganna Leonenko, Feifei Tao, Emily Simmonds, Ying Wu, Niklas Mattsson-Carlgren, Oskar Hansson, Michael W. Nagle, Valentina Escott-Price

Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease

Allison Carles, Aline Freyssin, Sarra Guehairia, Thomas Reguero, Michel Vignes, Hélène Hirbec, Gilles Rubinstenn, Tangui Maurice

Effects of Alzheimer’s disease plasma marker levels on multilayer centrality in healthy individuals

Alejandra García-Colomo, David López-Sanz, Ignacio Taguas, Martín Carrasco-Gómez, Carlos Spuch, María Comis-Tuche, Fernando Maestú

Depressive symptoms in older adults are associated with changes in stress-related markers, functional connectivity and brain volume

Edelweiss Touron, Robin de Flores, Laurent Coulbault, Cassandre Palix, Anne Chocat, Elizabeth Kuhn, Brigitte Landeau, Florence Mézenge, Daniel Roquet, Léa Chauveau, Sacha Haudry, Denis Vivien, Vincent de La Sayette, Natalie L. Marchant, Gaël Chételat, Géraldine Poisnel, Florence Allais, Claire André, Pierre Champetier, Fabienne Collette, Sophie Dautricourt, Marion Delarue, Séverine Fauvel, Francesca Felisatti, Victor Ferment, Eglantine Ferrand-Devouge, Eric Frison, Julie Gonneaud, Antoine Garnier-Crussard, Anaïs Hamel, Oriane Hébert, Olga M. Klimecki, Pierre Krolak-Salmon, Valérie Lefranc, Antoine Lutz, Valentin Ourry, Anne Quillard, Géraldine Rauchs, Eric Salmon, Anne-Laure Turpin, Patrik Vuilleumier, Miranka Wirth

Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry

Jae Myeong Kang, Manchumad Manjavong, Chengshi Jin, Adam Diaz, Miriam T. Ashford, Joseph Eichenbaum, Emily Thorp, Elizabeth Wragg, Kenton H. Zavitz, Francesca Cormack, Anna Aaronson, R. Scott Mackin, Rachana Tank, Bernard Landavazo, Erika Cavallone, Diana Truran, Sarah Tomaszewski Farias, Michael W. Weiner, Rachel L. Nosheny

Neuronal CD59 isoforms IRIS-1 and IRIS-2 as regulators of neurotransmitter release with implications for Alzheimer’s disease

Ewelina Golec, Robin Olsson, Emre Can Tuysuz, Maja Karlsson, Yasmin Serjieh, Ben C. King, Malin Wennström, Anna M. Blom

Uncovering the epigenetic regulatory clues of PRRT1 in Alzheimer’s disease: a strategy integrating multi-omics analysis with explainable machine learning

Fang Wang, Ying Liang, Qin-Wen Wang

Variables associated with cognitive function: an exposome-wide and mendelian randomization analysis

Yong-Li Zhao, Yi-Ning Hao, Yi-Jun Ge, Yi Zhang, Lang-Yu Huang, Yan Fu, Dan-Dan Zhang, Ya-Nan Ou, Xi-Peng Cao, Jian-Feng Feng, Wei Cheng, Lan Tan, Jin-Tai Yu

evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer’s disease

Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

Post-marketing safety concerns with lecanemab: a pharmacovigilance study based on the FDA Adverse Event Reporting System database

Xiaoxuan Xing, Xiaotong Zhang, Ke Wang, Zhizhou Wang, Yingnan Feng, Xiaoxi Li, Yiming Hua, Lan Zhang, Xianzhe Dong

Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia

Diana Ortega-Cruz, Alberto Rabano, Bryan A. Strange

Brain iron deposition and cognitive decline in patients with cerebral small vessel disease : a quantitative susceptibility mapping study

Yian Gao, Changhu Liang, Qihao Zhang, Hangwei Zhuang, Chaofan Sui, Nan Zhang, Mengmeng Feng, Haotian Xin, Lingfei Guo, Yi Wang

Association of antihypertensive drug target genes with alzheimer’s disease: a mendelian randomization study

He Zheng, Chaolei Chen, Yingqing Feng

Association and multimodal model of retinal and blood-based biomarkers for detection of preclinical Alzheimer’s disease

Swetha Ravichandran, Peter J. Snyder, Jessica Alber, Charles F. Murchison, Lauren E. Chaby, Andreas Jeromin, Edmund Arthur

CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer’s disease mice

Yuanyu Shen, Xiaolei Zhang, Siqi Liu, Lijing Xin, Wentao Xuan, Caiyu Zhuang, Yue Chen, Beibei Chen, Xinhui Zheng, Renhua Wu, Yan Lin

Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease

Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case–control study

Stefan Teipel, Manas Akmatov, Bernhard Michalowsky, Steffi Riedel-Heller, Jens Bohlken, Jakob Holstiege

Effectiveness and utilization of a cognitive screening program for primary geriatric care

David P. Salmon, Anna Malkina, Melanie L. Johnson, Christina Gigliotti, Emily A. Little, Douglas Galasko

Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model

Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospective observational study

Noriyuki Kimura, Kotaro Sasaki, Teruaki Masuda, Takuya Ataka, Mariko Matsumoto, Mika Kitamura, Yosuke Nakamura, Etsuro Matsubara

Short-term variability of Alzheimer’s disease plasma biomarkers in a mixed memory clinic cohort

Frederikke Kragh Clemmensen, Mathias Holsey Gramkow, Anja Hviid Simonsen, Nicholas J. Ashton, Hanna Huber, Kaj Blennow, Henrik Zetterberg, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen

Exploring sex differences in Alzheimer’s disease: a comprehensive analysis of a large patient cohort from a memory unit

Maitee Rosende-Roca, Fernando García-Gutiérrez, Yahveth Cantero-Fortiz, Montserrat Alegret, Vanesa Pytel, Pilar Cañabate, Antonio González-Pérez, Itziar de Rojas, Liliana Vargas, Juan Pablo Tartari, Ana Espinosa, Gemma Ortega, Alba Pérez-Cordón, Mariola Moreno, Sílvia Preckler, Susanna Seguer, Miren Jone Gurruchaga, Lluís Tárraga, Agustín Ruiz, Sergi Valero, Mercè Boada, Marta Marquié

Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment

Julia Schumacher, Stefan Teipel, Alexander Storch

RADAR-AD: assessment of multiple remote monitoring technologies for early detection of Alzheimer’s disease

Manuel Lentzen, Srinivasan Vairavan, Marijn Muurling, Vasilis Alepopoulos, Alankar Atreya, Merce Boada, Casper de Boer, Pauline Conde, Jelena Curcic, Giovanni Frisoni, Samantha Galluzzi, Martha Therese Gjestsen, Mara Gkioka, Margarita Grammatikopoulou, Lucrezia Hausner, Chris Hinds, Ioulietta Lazarou, Alexandre de Mendonça, Spiros Nikolopoulos, Dorota Religa, Gaetano Scebba, Pieter Jelle Visser, Gayle Wittenberg, Vaibhav A. Narayan, Neva Coello, Anna-Katharine Brem, Dag Aarsland, Holger Fröhlich

The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice

Irene Santos-García, Pablo Bascuñana, Mirjam Brackhan, María Villa, Ivan Eiriz, Thomas Brüning, Jens Pahnke

Glymphatic system clearance and Alzheimer’s disease risk: a CSF proteome-wide study

Natalia Cullell, Giovanni Caruana, Andrea Elias-Mas, Ariane Delgado-Sanchez, Cristina Artero, Maria Teresa Buongiorno, Marta Almería, Nicola J. Ray, Sonia A. L. Correa, Jerzy Krupinski

Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor

Joshua D. Grill, Daniel Gillen

Retinal optical coherence tomography intensity spatial correlation features as new biomarkers for confirmed Alzheimer’s disease

Zi Jin, Xinmin Wang, Ying Lang, Yufeng Song, Huangxiong Zhan, Wuge Shama, Yingying Shen, Guihua Zeng, Faying Zhou, Hongjian Gao, Shuling Ye, Yanjiang Wang, Fan Lu, Meixiao Shen

Rotation errors in path integration are associated with Alzheimer’s disease tau pathology: a cross-sectional study

Lise Colmant, Lisa Quenon, Lara Huyghe, Adrian Ivanoiu, Thomas Gérard, Renaud Lhommel, Pauline Coppens, Yasmine Salman, Vincent Malotaux, Laurence Dricot, Lukas Kunz, Nikolai Axmacher, Philippe Lefèvre, Bernard Hanseeuw

Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB1 pathway

Yuan Xu, Naiyuan Shao, Feng Zhi, Ronghua Chen, Yilin Yang, Jiahui Li, Ying Xia, Ya Peng

Multi-omics analyses identify gut microbiota-fecal metabolites-brain-cognition pathways in the Alzheimer’s disease continuum

Han Zhao, Xia Zhou, Yu Song, Wenming Zhao, Zhongwu Sun, Jiajia Zhu, Yongqiang Yu

A systematic review and meta-analysis of the impact of transcranial direct current stimulation on cognitive function in older adults with cognitive impairments: the influence of dosage parameters

Thatchaya Prathum, Thanwarat Chantanachai, Oranich Vimolratana, Chotica Laksanaphuk, Irin Apiworajirawit, Benchaporn Aneksan, Kanthika Latthirun, Cheng-Ta Yang, Wanalee Klomjai

Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach

Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack Jr., Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, Laurel Beckett, Bernardino Ghetti, Lea T. Grinberg, Dustin Hammers, Clifford R. Jack Jr., Kala Kirby, Robert Koeppe, Walter A. Kukull, Renaud La Joie, Julien Lagarde, Melissa E. Murray, Kathy Newell, Angelina Polsinelli, Arthur Toga, David Clark, Ian Grant, Lawrence S. Honig

β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease

Bing Xu, Kang Xiao, Xiaoxi Jia, Rundong Cao, Donglin Liang, Ruhan A, Weiwei Zhang, Chunjie Li, Liping Gao, Cao Chen, Qi Shi, Xiaoping Dong

Treatment of Alzheimer's Disease subjects with expanded non-genetically modified autologous natural killer cells (SNK01): a phase I study

Clemente Humberto Zúñiga, Blanca Isaura Acosta, Rufino Menchaca, Cesar A. Amescua, Sean Hong, Lucia Hui, Minchan Gil, Yong-hee Rhee, Sangwook Yoon, Minji Kim, Paul Y. Chang, Yong Man Kim, Paul Y. Song, Katia Betito

Prediction of cognitive conversion within the Alzheimer’s disease continuum using deep learning

Siyu Yang, Xintong Zhang, Xinyu Du, Peng Yan, Jing Zhang, Wei Wang, Jing Wang, Lei Zhang, Huaiqing Sun, Yin Liu, Xinran Xu, Yaxuan Di, Jin Zhong, Caiyun Wu, Jan D. Reinhardt, Yu Zheng, Ting Wu

Plasma Hepcidin as a potential informative biomarker of Alzheimer disease and vascular dementia

Constance Delaby, Daniel Alcolea, Germain Busto, Audrey Gabelle, Xavier Ayrignac, Karim Bennys, Elena Muiño, Paula Villatoro, Israel Fernández-Cadenas, Nicolas Pradeilles, Shaima El Bounasri, Soraya Torres, Christophe Hirtz, Henrik Zetterberg, Alberto Lleó, Juan Fortea, Sylvain Lehmann

Pathway-based network medicine identifies novel natural products for Alzheimer’s disease

Yumei Liang, Siqi Xie, Jianping Jia

Circular RNA APP contributes to Alzheimer’s disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis

Deng-Pan Wu, Yan-Su Wei, Li-Xiang Hou, Yu-Xuan Du, Qiu-Qing Yan, Ling-Ling Liu, Yuan-Dan Zhao, Ru-Yu Yan, Chao Yu, Zhen-Guo Zhong, Jin-Lan Huang

Investigating the Aβ and tau pathology in autosomal dominant Alzheimer’s disease: insights from hybrid PET/MRI and network mapping

Zhi Zhou, Qigeng Wang, Linwen Liu, Qi Wang, Xiaojun Zhang, Can Li, Jiajin Liu, Yidan Wei, Jin Gao, Liping Fu, Ruimin Wang

Sex differences in the association of Alzheimer’s disease biomarkers and cognition in a multicenter memory clinic study

Cecilia Boccalini, Debora Elisa Peretti, Max Scheffler, Linjing Mu, Alessandra Griffa, Nathalie Testart, Gilles Allali, John O. Prior, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Giovanni B. Frisoni, Valentina Garibotto

Cornuside alleviates cognitive impairments induced by Aβ1−42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy

Fulin Zhou, Wenwen Lian, Xiaotang Yuan, Zexing Wang, Congyuan Xia, Yu Yan, Wenping Wang, Zhuohang Tong, Yungchi Cheng, Jiekun Xu, Jun He, Weiku Zhang

The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity

Burak Arslan, Wagner S. Brum, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Kübra Tan, Paolo Vitali, Maxime Montembeault, Jesse Klostranec, Arthur C. Macedo, Cecile Tissot, Serge Gauthier, Juan Lantero-Rodriguez, Eduardo R. Zimmer, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L. Benedet, Nicholas J. Ashton

γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds

  • Open Access
  • Research

Johannes Trambauer, Rosa Maria Rodriguez Sarmiento, Holly J. Garringer, Katja Salbaum, Liliana D. Pedro, Dennis Crusius, Ruben Vidal, Bernardino Ghetti, Dominik Paquet, Karlheinz Baumann, Lothar Lindemann, Harald Steiner

Social frailty and its association with cognitive trajectories in older adults: a prospective cohort study

Hui Zhang, Meng Hao, Zixin Hu, Shuai Jiang, Yi Li, Xiaofeng Wang, Xiangwei Li

Evaluation of cerebrospinal fluid levels of VAMP-2 and SNAP-25 in a dementia with Lewy bodies clinical cohort stratified by Alzheimer’s pathophysiological biomarkers

Alba Cervantes González, Julie Goossens, Elena Vera Campuzano, Isabel Sala, M. Belén Sánchez-Saudinós, Íñigo Rodríguez-Baz, Laia Lidón, Danna Perlaza, Alexandre Bejanin, Annakaisa Haapasalo, Juan Fortea, Daniel Alcolea, Alberto Lleó, Eugeen Vanmechelen, Olivia Belbin

Brain age mediates gut microbiome dysbiosis-related cognition in older adults

Sang Joon Son, Dong Yun Lee, Hyun Woong Roh, Maria Ly, Antonija Kolobaric, Howard Aizenstein, Carmen Andreescu, Eldin Jašarević, Tharick A. Pascoal, Pamela C. L Ferreira, Bruna Bellaver, Yong Hyuk Cho, Sunhwa Hong, You Jin Nam, Bumhee Park, Narae Kim, Jin Wook Choi, Jae Youn Cheong, Yoon-Keun Kim, Tae-Seop Shin, Chil-Sung Kang, Cheol-O Kwon, Seo-Yoon Yoon, Chang Hyung Hong, Helmet T. Karim

Probing locus coeruleus functional network in healthy aging and its association with Alzheimer’s disease biomarkers using pupillometry

Junjie Wu, Aaron Toporek, Qixiang Lin, Felicia C. Goldstein, David W. Loring, Michael A. Kelberman, David Weinshenker, Allan I. Levey, James J. Lah, Deqiang Qiu

Identification and characterization of variants in PSEN1, PSEN2, and APP genes in Chinese patients with early-onset Alzheimer's disease

Haitian Nan, Min Chu, Deming Jiang, Wenping Liang, Yu Li, Yiming Wu, Zhe Wang, Liyong Wu

HCN2 deficiency correlates with memory deficits and hyperexcitability of dCA1 pyramidal neurons in Alzheimer’s disease

Xiaoqin Zhang, Yiping Zhang, Ting Zhang, Jing Wang, Chang Liu, Qing Shang, Xiaojie Wei, Huaqiang Zhu, Haowei Shen, Binggui Sun

Synaptic protein CSF levels relate to memory scores in individuals without dementia

Kirsten E. J. Wesenhagen, Diederick M. de Leeuw, Jori Tomassen, Johan Gobom, Isabelle Bos, Stephanie J. B. Vos, Pablo Martinez-Lage, Mikel Tainta, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Rik Vandenberghe, Yvonne Freund-Levi, Frans Verhey, Simon Lovestone, Johannes Streffer, Valerija Dobricic, Kaj Blennow, Philip Scheltens, August B. Smit, Lars Bertram, Charlotte E. Teunissen, Henrik Zetterberg, Betty M. Tijms, Pieter Jelle Visser

TREM2 risk variants and associated endophenotypes in alzheimer’s disease

Janna I. R. Dijkstra, Lisa Vermunt, Vikram Venkatraghavan, Georgii Ozhegov, Emma M. Coomans, Rik Ossenkoppele, Elsmarieke van de Giessen, Marc Hulsman, Christa M. de Geus, Wiesje M. van der Flier, Sietske A. M. Sikkes, Frederik Barkhof, Betty Tijms, Alida A. Gouw, Willem de Haan, Everard G. B. Vijverberg, Yolande A. L. Pijnenburg, Henne Holstege, Charlotte E. Teunissen, Sven J. van der Lee

Diabetes status, duration, and risk of dementia among ischemic stroke patients

Jonguk Kim, Kyung-Do Han, Jeong-Yoon Lee, Ye Seul Yang, Dae Young Cheon, Jae-Jun Lee, Minwoo Lee

Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer’s disease

Gabriel L Ketron, Felix Grun, Joshua D Grill, Howard H Feldman, Robert A Rissman, Gregory J Brewer

Beyond expectations: investigating nilotinib’s potential in attenuating neurodegeneration in Alzheimer’s disease

Darcy Tocci, Maiah Fogel, Vanya Gupta, Peter Kim, Jean Latimer, Aida Adlimoghaddam, Lisa S. Robison, Benedict C. Albensi

Adherence and intensity in multimodal lifestyle-based interventions for cognitive decline prevention: state-of-the-art and future directions

Natalia Soldevila-Domenech, Amaia Ayala-Garcia, Mariagnese Barbera, Jenni Lehtisalo, Laura Forcano, Ana Diaz-Ponce, Marissa Zwan, Wiesje M. van der Flier, Tiia Ngandu, Miia Kivipelto, Alina Solomon, Rafael de la Torre

Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function

Philine Marie Schirge, Robert Perneczky, Toshiaki Taoka, Adriana L. Ruiz-Rizzo, Ersin Ersoezlue, Robert Forbrig, Selim Guersel, Carolin Kurz, Matthias Brendel, Julian Hellmann-Regen, Josef Priller, Anja Schneider, Frank Jessen, Emrah Düzel, Katharina Buerger, Stefan Teipel, Christoph Laske, Oliver Peters, Eike Spruth, Klaus Fliessbach, Ayda Rostamzadeh, Wenzel Glanz, Daniel Janowitz, Ingo Kilimann, Sebastian Sodenkamp, Michael Ewers, Boris-Stephan Rauchmann

Correction: Cornuside alleviates cognitive impairments induced by Aβ1−42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy

  • Open Access
  • Correction

Fulin Zhou, Wenwen Lian, Xiaotang Yuan, Zexing Wang, Congyuan Xia, Yu Yan, Wenping Wang, Zhuohang Tong, Yungchi Cheng, Jiekun Xu, Jun He, Weiku Zhang

Tau-PET pathology in the subregions of the amygdala and its associations with cognitive performance and neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease

Catarina Tristão-Pereira, Stephanie Langella, Justin S. Sanchez, Vincent Malotaux, Bing He, Jorge Alcina, Jairo E. Martinez, Zoe Rubinstein, Ana Baena, Clara Vila-Castelar, Averi Giudicessi, Liliana Ramirez Gomez, Claudia Ramos, Daniel Vasquez, David Aguillon, Heidi I. L. Jacobs, Reisa A. Sperling, Keith Johnson, Jennifer R. Gatchel, Yakeel T. Quiroz

Impact of sleep apnea on alzheimer’s disease in relation to sex: an 8-year longitudinal follow-up study of a nationwide cohort

Su Jin Chung, Sung Hoon Kang, Minwoong Kang, Yunjin Choi, Yu Jeong Park, Hayom Kim, Kyungmi Oh, Seong-Beom Koh, Jung Bin Kim

Impact of effective connectivity within the Papez circuit on episodic memory: moderation by perivascular space function

Ling-Ling Li, Jie Ma, Jia-Jia Wu, Xin Xue, Mou-Xiong Zheng, Xu-Yun Hua, Qi-Hao Guo, Jian-Guang Xu

Accelerometer-derived “weekend warrior” physical activity, sedentary behavior, and risk of dementia

Yuye Ning, Meilin Chen, Hao Yang, Jianping Jia

Diagnostic performance of plasma p-tau217 in a memory clinic cohort using the Lumipulse automated platform

Francisco Martínez-Dubarbie, Armando Guerra-Ruiz, Sara López-García, Carmen Lage, Marta Fernández-Matarrubia, Álvaro Nevado-Cáceres, María Rivera-Sánchez, Andrea Valera-Barrero, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Enrique Marco de Lucas, Marta Drake-Pérez, Nancy Heidy Cahuana-Santamaría, María Teresa García-Unzueta, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez

Effects of 52 weeks of precuneus rTMS in Alzheimer’s disease patients: a randomized trial

Giacomo Koch, Elias Paolo Casula, Sonia Bonnì, Ilaria Borghi, Martina Assogna, Francesco Di Lorenzo, Romina Esposito, Michele Maiella, Alessia D’Acunto, Matteo Ferraresi, Lucia Mencarelli, Valentina Pezzopane, Caterina Motta, Emiliano Santarnecchi, Marco Bozzali, Alessandro Martorana

Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease

Akihiro Kitani, Yusuke Matsui

Evaluating the diagnostic performance of six plasma biomarkers for Alzheimer’s disease and other neurodegenerative dementias in a large Chinese cohort

Bin Jiao, Ziyu Ouyang, Yiliang Liu, Cong Zhang, Tianyan Xu, Qijie Yang, Sizhe Zhang, Yuan Zhu, Meidan Wan, Xuewen Xiao, Xixi Liu, Yafang Zhou, Xinxin Liao, Weiwei Zhang, Shilin Luo, Beisha Tang, Lu Shen

Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer’s disease

Hongli Chen, Na Li, Na Liu, Hongyu Zhu, Chunyan Ma, Yutong Ye, Xinyu Shi, Guoshuai Luo, Xiaoxi Dong, Tao Tan, Xunbin Wei, Huijuan Yin

Fibre density and cross-section associate with hallmark pathology in early Alzheimer’s disease

Greet Vanderlinden, Ahmed Radwan, Daan Christiaens, Jeroen Blommaert, Stefan Sunaert, Mathieu Vandenbulcke, Michel Koole, Koen Van Laere

Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration

Lorenzo Gaetano Amato, Alberto Arturo Vergani, Michael Lassi, Jacopo Carpaneto, Salvatore Mazzeo, Valentina Moschini, Rachele Burali, Giovanni Salvestrini, Carlo Fabbiani, Giulia Giacomucci, Giulia Galdo, Carmen Morinelli, Filippo Emiliani, Maenia Scarpino, Sonia Padiglioni, Benedetta Nacmias, Sandro Sorbi, Antonello Grippo, Valentina Bessi, Alberto Mazzoni

Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden

Clémence Cavaillès, Sylvaine Artero, Jerome J. Maller, Isabelle Jaussent, Yves Dauvilliers

Circadian rhythm disturbances in Alzheimer’s disease: insights from plaque-free and plaque-burdened stages in APPSWE/PS1dE9 mice

Huijia Yang, Long Niu, Lulu Tian, Yiying Hu, Cheng Cheng, Song Li, Weidong Le

Reply: [Post-marketing safety concerns with Lecanemab: a disproportionality analysis using the FDA adverse event reporting system]

Xiaoxuan Xing, Ke Wang, Xianzhe Dong

Anticipatory reaching motor behavior characterizes patients within the Alzheimer’s disease continuum in a virtual reality environment

Alessia de Nobile, Ilaria Borghi, Paolo De Pasquale, Denise Jennifer Berger, Antonella Maselli, Francesco Di Lorenzo, Elena Savastano, Martina Assogna, Andrea Casarotto, Daniele Bibbo, Silvia Conforto, Francesco Lacquaniti, Giacomo Koch, Andrea d’Avella, Marta Russo

Atrophy trajectories in Alzheimer’s disease: how sex matters

Anna Inguanzo, Konstantinos Poulakis, Javier Oltra, Silvia Maioli, Anna Marseglia, Daniel Ferreira, Rosaleena Mohanty, Eric Westman

Long-term surveillance of the anti-amyloid monoclonal antibody lecanemab: rights and duties of pharmacovigilance

Monia Donati, Angela Boccia, Fabrizio De Ponti, Elisabetta Poluzzi, Emanuel Raschi

Novel CSF β-synuclein-specific assays signal early synaptic degeneration in Alzheimer’s disease

Sherif Bayoumy, Julie Goossens, Charlotte De Rocker, Senna Y. Sie, Nolan J. Barrett, Wiesje M. van der Flier, Charlotte E. Teunissen, Eugeen Vanmechelen, Inge M. W. Verberk

Enhanced associations between subjective cognitive concerns and blood-based AD biomarkers using a novel EMA approach

Ángel García de la Garza, Caroline Nester, Cuiling Wang, Jacqueline Mogle, Nelson Roque, Mindy Katz, Carol A. Derby, Richard B. Lipton, Laura Rabin

Correction: γ‑Secretase modulator resistance of an aggressive Alzheimer‑causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds

  • Open Access
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Johannes Trambauer, Rosa Maria Rodriguez Sarmiento, Holly J. Garringer, Katja Salbaum, Liliana D. Pedro, Dennis Crusius, Ruben Vidal, Bernardino Ghetti, Dominik Paquet, Karlheinz Baumann, Lothar Lindemann, Harald Steiner

Impact of nucleos(t)ide analogue therapy on the incidence of Alzheimer’s disease in patients with chronic hepatitis B virus infection

Jihye Lim, Hyundam Gu, Hyunji Sang, Su Jin Jeong, Ha Il Kim

Relationships between blood pressure indicators and fluid biomarkers of brain aging in functionally intact older adults

Anna M. VandeBunte, Bailey L. Ortiz, Emily W. Paolillo, Rowan Saloner, Valentina Diaz, Shubir Dutt, Claire J. Cadwallader, Coty Chen, Argentina Lario Lago, Julio C. Rojas, Brandon Chan, Isabel Sible, Joel H. Kramer, Kaitlin B. Casaletto

Abdominal obesity and the risk of young-onset dementia in women: a nationwide cohort study

Ye Seul Yang, Kyungdo Han, Dae Young Cheon, Minwoo Lee

Correction: Investigating the Aβ and tau pathology in autosomal dominant Alzheimer’s disease: insights from hybrid PET/MRI and network mapping

Zhi Zhou, Qigeng Wang, Linwen Liu, Qi Wang, Xiaojun Zhang, Can Li, Jiajin Liu, Yidan Wei, Jin Gao, Liping Fu, Ruimin Wang

DNA methylation signature of a lifestyle-based resilience index for cognitive health

Wei Zhang, David Lukacsovich, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Eden R. Martin, Brian W. Kunkle, X. Steven Chen, Deirdre M. O’Shea, James E. Galvin, Lily Wang

Optimizing midlife metabolic syndrome thresholds for dementia: a prospective study of two UK population-based cohorts

Sam Vidil, Archana Singh-Manoux, Benjamin Landré, Aurore Fayosse, Séverine Sabia, Marcos D. Machado-Fragua

Associations of choroid plexus volume with white matter hyperintensity volume and susceptibility and plasma amyloid markers in cerebral small vessel disease

Pengcheng Liang, Meng Li, Yiwen Chen, Zhenyu Cheng, Na Wang, Yuanyuan Wang, Nan Zhang, Yena Che, Jing Li, Changhu Liang, Lingfei Guo

Differential effects of aging, Alzheimer's pathology, and APOE4 on longitudinal functional connectivity and episodic memory in older adults

Larissa Fischer, Jenna N. Adams, Eóin N. Molloy, Niklas Vockert, Jennifer Tremblay-Mercier, Jordana Remz, Alexa Pichet Binette, Sylvia Villeneuve, Anne Maass

Response to Xing et al.: post-marketing safety concerns with Lecanemab: a pharmacovigilance study based on the FDA adverse event reporting system database

  • Open Access
  • Matters Arising

Michael Irizarry, Ilona Surick, Ari Michael, Lynn D. Kramer

Clinical phenotypes of Alzheimer’s disease: investigating atrophy patterns and their pathological correlates

Niels Reijner, I. Frigerio, M. M. A. Bouwman, B. D. C. Boon, N. Guizard, T. Jubault, J. J. M. Hoozemans, A. J. M. Rozemuller, F. H. Bouwman, F. Barkhof, E. Gordon, W. D. J. van de Berg, L. E. Jonkman

Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice

Maria Luisa De Paolis, Gilda Loffredo, Paraskevi Krashia, Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Lucy Babicola, Matteo Di Segni, Roberto Coccurello, Stefano Puglisi-Allegra, Emanuele Claudio Latagliata, Marcello D’Amelio

The autocrine motility factor receptor delays the pathological progression of Alzheimer’s disease via regulating the ubiquitination-mediated degradation of APP

Jingjing Zhang, Congcong Liu, Jing Liu, Yuting Cui, Yuli Hou, Qiao Song, Xiaomin Zhang, Xiaoling Wang, Qian Zhang, Min Cao, Wenchao Wang, Peichang Wang, Yaqi Wang

Early presentation of spastic paraparesis in individuals carrying PSEN1 mutations: a clinical and genetic analysis

Kang-Yang Jih, Ting-Rong Hsu, Jong-Ling Fuh, Tse-Hao Lee, Yung-Shuan Lin, Shih-Yu Fang, Yi-Chu Liao, Yi-Chung Lee

Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease

Yuqi Qiu, Diane M. Jacobs, Karen Messer, David P. Salmon, Cheryl L. Wellington, Sophie Stukas, Carolyn Revta, James B. Brewer, Gabriel C. Léger, Brianna Askew, Lia Donahue, Stephen Kaplita, Vladimir Coric, Irfan A. Qureshi, Howard H. Feldman, Thomas Obisesan, Amanda Smith, Judith Heidebrink, Jacobo Mintzer, Thomas Ala, Aimee Pierce, Lon Schneider, Judith Heidebrink, Karen Bell, Milap Nowrangi, Amanda Smith, Gregory Jicha, Oscar Lopez, Anton Porsteinsson, Angela Jefferson, Martin Farlow, Christopher van Dyck, Ian Grant, Alan Siegal, Bryan Spann, Alireza Atri, Alan Lerner, Douglas Scharre, Del D. Miller, Elaine Peskind, Jonathan Drake, Aaron Ritter, Charles Bernick, Ralph Richter, Michael Karathanos, Jacobo Mintzer, Olga Brawman-Mintzer, Bernard Baumel, Jeffrey Keller, Andrea Bozoki, Christos Sidiropoulos, Sharon Brangman, Olga Tchikindas, Kiran Bath, David Weisman, Clifford Singer, Maya Lichtenstein, Mary Sano, James J. Peters, Alexander Beyzer, Richard Shubin, Peter McCallister, Stephen Flitman, Cherian Verghese, Sudha Seshadri, Anna Burke, Jeffrey Ross, Mark Brody

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

Elaheh Salardini, Ryan S. O’Dell, Em Tchorz, Nabeel B. Nabulsi, Yiyun Huang, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca

“It seems enormously valuable to me.” Perspectives of Dutch (potential) carriers of genetic FTD on onset-predictive biomarker testing

Charlotte H. Graafland, Harro Seelaar, Jessica L. Panman, Lize C. Jiskoot, Tjitske Kleefstra, Jackie M. Poos, Edo Richard, Maartje H.N. Schermer, John C. van Swieten, Laura Donker Kaat, Eline M. Bunnik

Soluble SorLA in CSF, a novel biomarker to explore disrupted trafficking of SorLA protein in Alzheimer disease

Romain Castelot, Aline Zarea, David Wallon, Anne Rovelet-Lecrux, Catherine Schramm, Muriel Quillard-Muraine, Anne Beaume, Frédéric Blanc, Olivier Bousiges, Julien Dumurgier, Maïté Formaglio, Gwenael Leguyader, Sylvain Lehmann, Cecilia Marelli, Matthieu Martinet, Leonor Nogueira, Jérémie Pariente, Isabelle Quadrio, Adeline Rollin-Sillaire, Susanna Schraen, Gaël Nicolas, Magalie Lecourtois

The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailty in Malaysia: The AGELESS Trial

  • Open Access
  • Research

Pavapriya Ponvel, Suzana Shahar, Devinder Kaur Ajit Singh, Arimi Fitri Mat Ludin, Ponnusamy Subramaniam, Norhayati Ibrahim, Hasnah Haron, Aniza Ismail, Chin Ai-Vyrn, Mazlyfarina Mohamad, Hidayah Fadzil, Norhayati Mustafa Khalid, A’isyah Mohammad Safien, Jamilah Mohammad Hanipah, Azyana Ibrahim, Jenni Lehtisalo, Miia Kivipelto, Francesca Mangialasche

Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine

Wenjing Feng, Mengwei Ju, Tao Wang, Shanshan Cui, Kexin Yang, Zhiting Guo, Miao Liu, Jiaxuan Tao, Huiyan Yu, Rong Xiao

Development and validation of a novel predictive model for dementia risk in middle-aged and elderly depression individuals: a large and longitudinal machine learning cohort study

Xuan Xiao, Yihui Li, Qiaoboyang Wu, Xinting Liu, Xu Cao, Maiping Li, Jianjing Liu, Lianggeng Gong, Xi-jian Dai

tRFAla-AGC-3-M8 attenuates neuroinflammation and neuronal damage in Alzheimer’s disease via the EphA7-ERK1/2-p70S6K signaling pathway

Zihao Deng, Yudi Li, Wenjun Chi, Wanzhou Zhang, Fangming Li, Li Ling

Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer’s disease

David Alcantara-Gonzalez, Meghan Kennedy, Chiara Criscuolo, Justin Botterill, Helen E. Scharfman

Revealing heterogeneity in mild cognitive impairment based on individualized structural covariance network

Xiaotong Wei, Ronglong Xiong, Ping Xu, Tingting Zhang, Junjun Zhang, Zhenlan Jin, Ling Li

Deep normative modelling reveals insights into early-stage Alzheimer's disease using multi-modal neuroimaging data

Ana Lawry Aguila, Luigi Lorenzini, Mohammed Janahi, Frederik Barkhof, Andre Altmann

Shared genetic architecture between leukocyte telomere length and Alzheimer’s disease

Zhi Cao, Qilong Tan, Hongxi Yang, Chenjie Xu

Cannabidiol as a multifaceted therapeutic agent: mitigating Alzheimer's disease pathology and enhancing cognitive function

Iu Raïch, Jaume Lillo, Joan Biel Rebassa, Christian Griñán-Ferré, Aina Bellver-Sanchis, Irene Reyes-Resina, Rafael Franco, Mercè Pallàs, Gemma Navarro

Correction: Short‑term variability of Alzheimer’s disease plasma biomarkers in a mixed memory clinic cohort

Frederikke Kragh Clemmensen, Mathias Holsey Gramkow, Anja Hviid Simonsen, Nicholas J. Ashton, Hanna Huber, Kaj Blennow, Henrik Zetterberg, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen

Diagnostic performance of actigraphy in Alzheimer’s disease using a machine learning classifier – a cross-sectional memory clinic study

Mathias Holsey Gramkow, Andreas Brink-Kjær, Frederikke Kragh Clemmensen, Nikolai Sulkjær Sjælland, Gunhild Waldemar, Poul Jennum, Steen Gregers Hasselbalch, Kristian Steen Frederiksen

Development of a Japanese polygenic risk score model for amyloid-β PET imaging in Alzheimer’s disease

Misato Kaishima, Junichi Ito, Kentaro Takahashi, Kenji Tai, Junro Kuromitsu, Shogyoku Bun, Daisuke Ito

Correction: Abdominal obesity and the risk of young-onset dementia in women: a nationwide cohort study

Ye Seul Yang, Kyungdo Han, Dae Young Cheon, Minwoo Lee

Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model

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  • Research

Markus Kraller, Julia Faßbender, Ammar Jabali, Joseph Kroeger, Barbara Fink, Bastian Popper, Martin Ungerer, Miriam A. Christlmeier

Influence of co-pathology on CSF and plasma synaptic markers SNAP25 and VAMP2 in Alzheimer’s disease and Parkinson’s disease

Lorenzo Gaetani, Giovanni Bellomo, Davide Chiasserini, Charlotte De Rocker, Julie Goossens, Federico Paolini Paoletti, Eugeen Vanmechelen, Lucilla Parnetti

Navigating the introduction of anti-amyloid therapy in Europe: a position statement by individual members of the EADC

Kristian S. Frederiksen, Mercé Boada, Bruno Dubois, Sebastiaan Engelborghs, Giovanni B. Frisoni, Jean Georges, Jakub Hort, Linus Jönsson, Milica G. Kramberger, Pierre-Jean Ousset, Nikolaos Scarmeas, Reinhold Schmidt, Jonathan M. Schott, Luiza Spiro, Gunhild Waldemar, Bengt Winblad, Frank Jessen, Lutz Frölich

Research on the perspectives of people affected by dementia with Lewy bodies: a scoping review

Paula Sinead Donnelly, Aoife Sweeney, Anthony P. Passmore, Noleen K. McCorry, Joseph P. M. Kane

Protein co-aggregates of dense core amyloid plaques and CSF differ in rapidly progressive Alzheimer’s disease and slower sporadic Alzheimer’s disease

Gurkan Bebek, Masaru Miyagi, Xinglong Wang, Brian S. Appleby, James B. Leverenz, Jagan A. Pillai

Lecanemab in clinical practice: real-world outcomes in early Alzheimer’s disease

Noa Bregman, Talya Nathan, Dror Shir, Nurit Omer, Mori Hai Levy, Aya Bar David, Orna Aizenstien, Eyal Lotan, Yifat Alcalay, Anan Abu Awad, Avi Gadoth, Elissa Ash, Tamara Shiner

Hypertension and diabetes on cognitive impairment: a case–control study in China

Jing Wu, Xiangjun Yin, Weiqiang Ji, Yang Liu, Jing Tang, Han Zhang, Shige Qi, Jie Li, Li Lin, Xueqing Yang, Chengdong Xu, Qingfeng Du

Hippocampal subfields: volume, neuropathological vulnerability and cognitive decline in Alzheimer’s and Parkinson’s disease

Maud M. A. Bouwman, Irene Frigerio, Chen-Pei Lin, Niels Reijner, Wilma D. J. van de Berg, Laura E. Jonkman

Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer’s disease pathology

Kang-Chen Fan, Chen-Ching Lin, Yen-Ling Chiu, Seong-Ho Koh, Yi-Chien Liu, Yi-Fang Chuang

Towards a national registry for Alzheimer’s disease and related dementias: rationale, design, and initial observations of the ABOARD cohort

Casper de Boer, Hanneke F. M. Rhodius-Meester, Sophie M. van der Landen, Jurgen Claassen, Romy de Haan, Janne M. Papma, Harro Seelaar, Marleen Kloppenburg-Lagendijk, Barbara van Munster, Marjolein de Vugt, Derk Arts, Marco Blom, Tanja J. de Rijke, Miriam Beusink, Robbert Huijsman, Evert-Ben van Veen, Argonde van Harten, Jort Vijverberg, Marissa Zwan, Henk-Jan Mutsaerts, Sven J. van der Lee, Wiesje M. van der Flier

Associations between platelet indices and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study

Shi-Yin Xiong, Yong-Li Zhao, Yan Fu, Qiong-Yao Li, Quan Hao, Dan-Dan Zhang, Min Liu, Shan Yin, Lan-Yang Wang, Yong-Chang Wang, Shu-Dong Qiu, Zi-Qi Zhang, Lan Tan

Digital twins and non-invasive recordings enable early diagnosis of Alzheimer’s disease

Lorenzo Gaetano Amato, Michael Lassi, Alberto Arturo Vergani, Jacopo Carpaneto, Salvatore Mazzeo, Valentina Moschini, Rachele Burali, Giovanni Salvestrini, Carlo Fabbiani, Giulia Giacomucci, Giulia Galdo, Carmen Morinelli, Filippo Emiliani, Maenia Scarpino, Sonia Padiglioni, Benedetta Nacmias, Sandro Sorbi, Antonello Grippo, Valentina Bessi, Alberto Mazzoni

Deep-learning based multi-modal models for brain age, cognition and amyloid pathology prediction

Chenxi Wang, Weiwei Zhang, Ming Ni, Qiong Wang, Chang Liu, Linbin Dai, Mengguo Zhang, Yong Shen, Feng Gao

Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin

Arnaud Mary, Samantha Barale, Fanny Eysert, Audrey Valverde, Sandra Lacas-Gervais, Charlotte Bauer, Sabiha Eddarkaoui, Luc Buée, Valérie Buée-Scherrer, Frédéric Checler, Mounia Chami

Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer’s disease and dementia with lewy bodies

Jinghuan Gan, Ziming Xu, Chen Wen, Hao Wu, Zhichao Chen, Zhihong Shi, Hao Lu, Yajie Wang, Shuai Liu, Yong Ji

Revisiting the therapeutic landscape of tauopathies: assessing the current pipeline and clinical trials

Glenn A. Harris, Lauren R. Hirschfeld, M. Isabel Gonzalez, Martyn C. Pritchard, Patrick C. May

Genetic background and multidomain interventions in mild cognitive impairment

Kosuke Fujita, Tetsuaki Kimura, Akiko Yamakawa, Shumpei Niida, Kouichi Ozaki, Takashi Sakurai, Hidenori Arai, Daichi Shigemizu

Plasma biomarkers for early detection of alzheimer’s disease: a cross-sectional study in a Japanese cohort

Masahito Kubota, Shogyoku Bun, Keisuke Takahata, Shin Kurose, Yuki Momota, Yu Iwabuchi, Toshiki Tezuka, Hajime Tabuchi, Morinobu Seki, Yasuharu Yamamoto, Ryo Shikimoto, Yu Mimura, Takayuki Hoshino, Sho Shimohama, Natsumi Suzuki, Ayaka Morimoto, Azusa Oosumi, Yuka Hoshino, Kenji Tai, Hirofumi Aoyagi, Yoshiaki Sato, Junro Kuromitsu, Jin Nakahara, Masaru Mimura, Daisuke Ito

AP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer’s disease

Yangyang Wang, Siyu Li, Xiao Liang, Jianing Fan, Shijie Li, Fanlin Zhou, Xiaoju Li, Mengmeng Lai, Dianmao Feng, Yu Li

Deuteration may reduce the efficacy of dextromethorphan in treating agitation in Alzheimer’s disease

Anton Bespalov, Jina Swartz, Nadine Knowles, Hans J. Moebius

Independent validation and outlier analysis of EuroPOND alzheimer’s disease staging model using ADNI and real-world clinical data

  • Open Access
  • EBM
  • Research

Mandy M. J. Wittens, Diana M. Sima, Arne Brys, Hanne Struyfs, Ellis Niemantsverdriet, Ellen De Roeck, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Peter Paul de Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Gaëtane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Evert Thiery, Jos Tournoy, Anne-Marie van Binst, Jan Versijpt, Dirk Smeets, Maria Bjerke, Maura Bellio, Neil P. Oxtoby, Daniel C. Alexander, Annemie Ribbens, Sebastiaan Engelborghs

Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer’s disease dementia

Tingyang Hu, Qiang Liu, Qile Dai, Aron S. Buchman, David A. Bennett, Shinya Tasaki, Yanling Wang, Nicholas T. Seyfried, Philip L. De Jager, Michael P. Epstein, Jingjing Yang

A longitudinal study of the 5xFAD mouse retina delineates Amyloid beta (Aβ)-mediated retinal pathology from age-related changes

Savannah A. Lynn, Sudha Priya Soundara Pandi, Aida Sanchez-Bretano, Anna-Marie Muir, Lidia Parker, David S. Chatelet, Tutte Newall, Jennifer A. Scott, Eloise Keeling, Neil R. Smyth, Jay E. Self, Andrew J. Lotery, Helena Lee, J. Arjuna Ratnayaka

Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL results

Natasha Z. Anita, Wassim Tarraf, Sayaka Kuwayama, Freddie Márquez, Charles DeCarli, Bharat Thyagarajan, Nora Franceschini, James P. Lash, Tanya Johns, Kevin A. González, Martha Daviglus, Haibo Zhou, Ariana M. Stickel, Frank J. Penedo, Tatjana Rundek, Doug Galasko, Hector M. González

Delphinidin attenuates cognitive deficits and pathology of Alzheimer’s disease by preventing microglial senescence via AMPK/SIRT1 pathway

Ying Liu, Ting Hong, Mingxuan Lv, Xiaoyu Guo, Panpan Zhang, Aijuan Yan, Wenshi Wei

Edaravone-Dexborneol slows down pathological progression and cognitive decline via inhibiting S100A9 in APPswe/PS1dE9 mice

Rui Mao, Shu Shu, Min Sun, Jiang Chen, Mengsha Hu, Lei Ye, Siyi Xu, Junqiu Jia, Wenxuan Shao, Xinyu Bao, Yun Xu, Xiaolei Zhu

Long-term electroacupuncture and repetitive transcranial magnetic stimulation differentially slow the progression of Alzheimer's disease in AppNL−G−F mice

Si-Min Song, Qian-Min Liu, Xi Huang, Ping Chen, Min Tao, Xia Pei, Hua-Ning Wang, Yan Han, Jian-Guo Chen, Wei Hong, Zhang-Jin Zhang

Photobiomodulation mitigates blood–brain barrier disruption in APP/PS1 mouse model of Alzheimer’s disease by activating the AMPK pathway

Chunyan Ma, Yutong Ye, Xinyu Shi, Na Li, Zhiming Mu, Tao Tan, Huijuan Yin, Jianwu Dai, Yi Liu, Hongli Chen

The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors

Eva Gläser, Ingo Kilimann, Moritz Platen, Wolfgang Hoffmann, Frederic Brosseron, Katharina Buerger, Marie Coenjaerts, Emrah Düzel, Michael Ewers, Klaus Fliessbach, Ingo Frommann, Maria Gemenetzi, Wenzel Glanz, Julian Hellmann-Regen, Enise I. Incesoy, Daniel Janowitz, Frank Jessen, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan Teipel, Michael Wagner, Bernhard Michalowsky

Arhgef7 as a key target for enriched environment rescuing spatial cognitive deficits and anxiety-like behaviors in a mouse model of Alzheimer’s disease following early social isolation

Yimiao Wang, Ze Wang, Yue Li, Min Cao, Shuying Zhang, Shixin Ding, Sijia Chen, Yuxi Jin, Yanli Zhang, Junying Gao, Ming Xiao

Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M1 positive allosteric modulator VU0467319 for Alzheimer’s disease: a single ascending-dose study in healthy participants

Alexander C. Conley, Alexandra P. Key, Jennifer U. Blackford, Jason K. Russell, Kimberly M. Albert, Xuewen Gong, Michael Bubser, Jerri M. Rook, P. Jeffrey Conn, Craig W. Lindsley, Carrie K. Jones, Paul A. Newhouse

Tau seeding activity in the cerebrospinal fluid of Alzheimer disease patients predicts short-term cognitive decline

Ludivine Houzé, Marc Dhenain, Suzanne Lam, Fanny Petit, Stéphane Haïk, François Mouton-Liger, Jacques Hugon, Julie Dam, Claire Paquet, Ralf Jockers, Erika Cecon

Low-dose interleukin-2 in patients with mild to moderate Alzheimer’s disease: a randomized clinical trial

Alireza Faridar, Nazaret Gamez, Daling Li, Yanling Wang, Reena Boradia, Aaron D. Thome, Weihua Zhao, David R. Beers, Jason R. Thonhoff, Mohammad O. Nakawah, Gustavo C. Román, John J. Volpi, Jon B. Toledo, Michael George, Charles S. Davis, Belen Pascual, Michael Grundman, Joseph C. Masdeu, Stanley H. Appel

Machine-learning based strategy identifies a robust protein biomarker panel for Alzheimer’s disease in cerebrospinal fluid

Xiaosen Hou, Yunjie Qiu, Hui Li, Yan Yan, Dongxu Zhao, Simei Ji, Junjun Ni, Jun Zhang, Kefu Liu, Hong Qing, Zhenzhen Quan

Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance

Giulia Dematteis, Chunmei Gong, Justyna Malecka, Elisa Tonelli, Armando Genazzani, Laura Tapella, Anna Maria Eleuteri, Dmitry Lim, Laura Bonfili

Predicting brain amyloid load with digital and blood-based biomarkers

Weineng Chen, Yu Liao, Xinchong Shi, Fengjuan Su, Haifan Kong, Yingying Fang, Yifan Zheng, Jiayi Zhou, Ganqiang Liu, Xianbo Zhou, Xiaoli Yao, Curtis B. Ashford, Feng Li, Long Yang, Michael F. Bergeron, J. Wesson Ashford, Xiangsong Zhang, Zhong Pei

Prospective evaluation of plasma pTau217 stability for the detection of Alzheimer’s disease in a tertiary memory clinic

Javier Arranz, Rosa Ferrer, Nuole Zhu, Sara Rubio-Guerra, Íñigo Rodríguez-Baz, José Enrique Arriola-Infante, Lucía Maure-Blesa, Jesús Garcia-Castro, Judit Selma-González, María Carmona-Iragui, Isabel Barroeta, Ignacio Illán-Gala, Miguel Santos-Santos, Juan Fortea, Alberto Lleó, Mireia Tondo, Daniel Alcolea

Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer’s disease biomarkers

Dobrin Nedelkov, Zoe E. Tsokolas, Matheus Scarpatto Rodrigues, Isabel Sible, S. Duke Han, Bilal E. Kerman, Michael Renteln, Wendy J. Mack, Tharick A. Pascoal, Hussein N. Yassine

Prognostic value of light reflex pupillometry in Alzheimer’s disease – a longitudinal cohort study

Mathias Holsey Gramkow, Frederikke Kragh Clemmensen, Ulrich Lindberg, Ian Law, Otto Mølby Henriksen, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen

An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels

Ting Yang, Yi Ran Xu, Shanxue Jin, Nagendran Ramalingam, Jean-Pierre Bellier, Alexandra M. Lish, Beth L. Ostaszewski, Tracy Young-Pearse, Lei Liu, Hyun-Sik Yang, Jasmeer P. Chhatwal, Trebor L. Lawton, Dennis J. Selkoe

Cerebral small vessel disease in memory center patients with dementia with lewy bodies and Alzheimer’s disease

Bommarito Giulia, Griffa Alessandra, Michel Patrik, Hall Caroline, Salvioni Chiabotti Paolo, Pistocchi Silvia, Alemán-Gómez Yasser, Damian Daniel, Jreige Mario, Prior John O., Dunet Vincent, Rouaud Olivier, Hagmann Patric, Allali Gilles

Comorbidities predict institutionalization and mortality in biomarker-confirmed alzheimer’s disease

Xin Xia, Alice Clark, Niels Juul Brogaard, Alex Mourer, Anna Areovimata, Maria Eriksdotter, Henrik Zetterberg, Silke Kern, Tobias Skillbäck, Linus Jönsson

The role of structural and functional parameters in designing pathology-specific tDCS protocols for primary progressive aphasia

Sagarika Bhattacharjee, P. T. Sivakumar, Ganesan Venkatasubramanian, Kenichi Oishi, Kyrana Tsapkini, S. H. Annabel Chen, Brenda Rapp, John E. Desmond, T. N. Sathyaprabha, Kaviraja Udupa, Rajan Kashyap

The efficacy and pharmacological mechanism of Guilingji to prevent Alzheimer’s disease

Fengrui Hu, Yaling Lei, Rui Han, Bo Yang, Yanlin Liang, Jing Luan, Bei Zhang, Shan wang, Xingchun Gou

Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study

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  • Research

Wen-Fang Zhong, Xiao-Meng Wang, Huan Chen, Wei-Qi Song, Jian Gao, Pei-Liang Chen, Qiao-Qiao Shen, Fang-Fei You, Chuan Li, Yue-Bin Lv, Zhi-Hao Li, Xiao-Ming Shi, Chen Mao

Cardiovascular risk factors are associated with lower posterior-medial network functional connectivity in older adults

Léa Chauveau, Julie Gonneaud, Géraldine Poisnel, Brigitte Landeau, Antoine Garnier-Crussard, Anne-Lise Pitel, Daniel Roquet, Edelweiss Touron, Sacha Haudry, Florence Mezenge, Anne Chocat, Denis Vivien, Vincent de La Sayette, Gaël Chételat, Robin de Flores

Combinatorial targeting of NMDARs and 5-HT4Rs exerts beneficial effects in a mouse model of Alzheimer’s disease

Briana K. Chen, Holly C. Hunsberger, Alicia Whye, Louise C. Matthews, Alyson Yook, Moshe J. Willner, Ryan W. Logan, Stefanie Johns, Eric Weisblum, Christine A. Denny

Age-related differences in Rostral-Middle locus coeruleus microstructure: A critical role in cognitive decline revealed by magnetic resonance relaxometry

Jonghyun Bae, Zhaoyuan Gong, Caio Mazucanti, Murat Bilgel, John P. Laporte, Mary E. Faulkner, Alex Guo, Christopher M. Bergeron, Josephine M. Egan, Susan M. Resnick, Christopher E. Ramsden, Mustapha Bouhrara

Dual risk of anticholinergic burden and CSF alzheimer’s biomarkers in older patients: a mortality follow-up study from daily medical practice

Théodore Decaix, Julien Dumurgier, Emmanuel Cognat, Karl Götze, François Mouton-Liger, Jacques Hugon, Elodie Bouaziz-Amar, Matthieu Lilamand, Claire Paquet

A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers

  • Open Access
  • Research

Andrés Rodríguez, Olga Calero, Sergio Veiga, Miriam Menacho-Román, Ignacio Arribas, Lluís Cano, Guillermo García-Ribas, Miguel Calero

Dec 24
Issue: 1/2024

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How can your team use biomarkers to improve management of AD? (Link opens in a new window)

Our experts explore using biomarker tests and interpreting results, establishing a shared decision-making approach with patients and caregivers, and applying biomarker testing to guide treatment strategies.

This content is intended for healthcare professionals outside of the UK.

Supported by:
  • Lilly
Developed by: Springer Health+ IME
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