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Inflammopharmacology

Open Access 12-03-2025 | Alzheimer's Disease | Original Article

Unveiling the neuroprotective potential of Ipomoea carnea ethanol extract via the modulation of tau and β-secretase pathways in AlCl3-induced memory impairment in rats in relation to its phytochemical profiling

Authors: Walaa A. El-Kashak, Ahmed F. Essa, Mohamed F. Abdelhameed, Yasmine H. Ahmed, Asmaa S. Abd Elkarim, Mai M. Elghonemy, Bassant M. M. Ibrahim, Ahmed H. Gaara, Tahia K. Mohamed, Abdelsamed I. Elshamy

Published in: Inflammopharmacology

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Abstract

Alzheimer’s disease (AD) is a widespread condition that affects adults and the community considerably. The causes are yet unknown, except from advanced age and genetic predisposition. Natural products provided advantageous advantages for managing AD due to their efficacy, safety, and accessibility. The memory boosting effects of chemically characterized Ipomoea carnea ethanol extract (IPC-EtOH) on behavioral, biochemical, histological, and molecular levels against cognitive impairment induced by AlCl3 exposure in rats were assessed using donepezil as a reference drug. Behavioral tests (spontaneous alternation T-maze and open field test) and assays for GSK3β, CREB, FOXO1a, β-secretase, tau, oxidative stress biomarkers, histopathology, and immunohistochemistry for cyclooxygenase 2 (COX-2) were conducted. The chemical profiling of IPC-EtOH using UPLC-ESI–qTOF-MS coupled with molecular networking revealed the identification of 83 bioactive metabolites, including pyrrolizidine alkaloids and cinnamic acid derivatives which previously undescribed from this species. AlCl3 injection significantly elevated tau, β-secretase, GSSG, GSK-3β, and FOXO3a levels and down regulated CAT, SOD, and CREB, with strong COX-2 immunoexpression in the cortex and hippocampus compared to controls. Oral co-administration of donepezil or IPC-EtOH to AlCl3-treated rats restored near-normal function in these brain regions, significantly attenuating spatial learning, memory, and locomotor impairments. These results suggest that IPC-EtOH could be a promising therapy for mitigating aluminum-induced neurotoxicity, though further studies are needed to elucidate its precise mechanisms of action. These outcomes emphasize I. carnea ethanol extract’s potential as an appealing therapy for AD by demonstrating its neuroprotective and memory-enhancing properties in rats having AlCl3-induced memory impairment.
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Metadata
Title
Unveiling the neuroprotective potential of Ipomoea carnea ethanol extract via the modulation of tau and β-secretase pathways in AlCl3-induced memory impairment in rats in relation to its phytochemical profiling
Authors
Walaa A. El-Kashak
Ahmed F. Essa
Mohamed F. Abdelhameed
Yasmine H. Ahmed
Asmaa S. Abd Elkarim
Mai M. Elghonemy
Bassant M. M. Ibrahim
Ahmed H. Gaara
Tahia K. Mohamed
Abdelsamed I. Elshamy
Publication date
12-03-2025
Publisher
Springer International Publishing
Published in
Inflammopharmacology
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-025-01687-0