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09-05-2024 | Alzheimer's Disease | Original Article

Ferulago Angulata methanolic extract ameliorates scopolamine-induced memory impairment through the inhibition of hippocampal monoamine oxidase activity

Authors: Samaneh hajimohammadi, Maliheh Soodi, Homa Hajimehdipoor, Salma Sefidbakht, Niloofar Mashhadi sharif

Published in: Metabolic Brain Disease | Issue 5/2024

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Abstract

Ferulago angulata is a medicinal herb from the Apiaceae family known for its antioxidant, anti-apoptotic, and neuroprotective properties. This study aimed to assess the effects of F. angulata extract on neurobehavioral and biochemical parameters in scopolamine-induced amnesic rats. Fifty-six male Wistar rats were divided into seven groups and orally treated with F. angulata extract (100, 200, 400 mg/kg) and Rivastigmine (1.5 mg/kg) for 10 days. Starting on the sixth day of treatment, the Morris water maze behavioral study was conducted to evaluate cognitive function, with scopolamine administered 30 min before training. Biochemical assays, including monoamine oxidase and oxidative stress measures, were performed on hippocampal tissue. Results showed that extract treatment significantly attenuated scopolamine-induced memory impairment in a dose-dependent manner. Following scopolamine administration, malondialdehyde levels and monoamine oxidase A/B activity increased, while total thiol content and catalase activity decreased compared to the control group. Pretreatment with F. angulata extracts ameliorated the scopolamine-induced impairment in all factors. Toxicological evaluation of liver, lung, heart, and kidney tissues did not indicate any side effects at high doses. The total extract of F. angulata prevents scopolamine-induced learning and memory impairment through antioxidant mechanisms and inhibition of monoamine oxidase. These results suggest that F. angulata extract is effective in the scopolamine model and could be a promising agent for preventing dementia, especially Alzheimer’s disease.
Literature
go back to reference Adedayo BC, Jesubowale OS, Adebayo AA, Oboh G (2021) Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine-induced amnesic rats. J Food Biochem 45(3):e13280 Adedayo BC, Jesubowale OS, Adebayo AA, Oboh G (2021) Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine-induced amnesic rats. J Food Biochem 45(3):e13280
go back to reference Akbari S, Soodi M, Hajimehdipoor H, Ataei N (2019) Protective effects of Sanguisorba minor and ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons. J Herbmed Pharmacol 8(3):248–255CrossRef Akbari S, Soodi M, Hajimehdipoor H, Ataei N (2019) Protective effects of Sanguisorba minor and ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons. J Herbmed Pharmacol 8(3):248–255CrossRef
go back to reference Ameen BAH (2014) Phytochemical study and cytotoxic activity of Ferulago Angulata (Schlecht) Boiss, from Kurdistan-region of Iraq. IJIRAE 1(9):1–5 Ameen BAH (2014) Phytochemical study and cytotoxic activity of Ferulago Angulata (Schlecht) Boiss, from Kurdistan-region of Iraq. IJIRAE 1(9):1–5
go back to reference Behl T, Kaur D, Sehgal A, Singh S, Sharma N, Zengin G, Andronie-Cioara FL, Toma MM, Bungau S, Bumbu AG (2021) Role of monoamine oxidase activity in alzheimer’s disease: an insight into the therapeutic potential of inhibitors. Molecules 26(12). Article 3724. https://doi.org/10.3390/molecules26123724 Behl T, Kaur D, Sehgal A, Singh S, Sharma N, Zengin G, Andronie-Cioara FL, Toma MM, Bungau S, Bumbu AG (2021) Role of monoamine oxidase activity in alzheimer’s disease: an insight into the therapeutic potential of inhibitors. Molecules 26(12). Article 3724. https://​doi.​org/​10.​3390/​molecules2612372​4
go back to reference Borroni E, Bohrmann B, Grueninger F, Prinssen E, Nave S, Loetscher H, Chinta SJ, Rajagopalan S, Rane A, Siddiqui A, Ellenbroek B, Messer J, Pähler A, Andersen JK, Wyler R, Cesura AM (2017) Sembragiline: a novel, selective monoamine oxidase type B inhibitor for the treatment of Alzheimer’s Disease. J Pharmacol Exp Ther 362(3):413–423. https://doi.org/10.1124/jpet.117.241653CrossRefPubMed Borroni E, Bohrmann B, Grueninger F, Prinssen E, Nave S, Loetscher H, Chinta SJ, Rajagopalan S, Rane A, Siddiqui A, Ellenbroek B, Messer J, Pähler A, Andersen JK, Wyler R, Cesura AM (2017) Sembragiline: a novel, selective monoamine oxidase type B inhibitor for the treatment of Alzheimer’s Disease. J Pharmacol Exp Ther 362(3):413–423. https://​doi.​org/​10.​1124/​jpet.​117.​241653CrossRefPubMed
go back to reference Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1–2):248–254CrossRefPubMed Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1–2):248–254CrossRefPubMed
go back to reference Do QD, Angkawijaya AE, Tran-Nguyen PL, Huynh LH, Soetaredjo FE, Ismadji S, Ju Y-H (2014) Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. J Food Drug Anal 22(3):296–302CrossRefPubMed Do QD, Angkawijaya AE, Tran-Nguyen PL, Huynh LH, Soetaredjo FE, Ismadji S, Ju Y-H (2014) Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. J Food Drug Anal 22(3):296–302CrossRefPubMed
go back to reference Griñán-Ferré C, Bellver-Sanchis A, Izquierdo V, Corpas R, Roig-Soriano J, Chillón M, Andres-Lacueva C, Somogyvári M, Sőti C, Sanfeliu C, Pallàs M (2021) The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: from antioxidant to epigenetic therapy. Ageing Res Rev 67:101271. https://doi.org/10.1016/j.arr.2021.101271CrossRefPubMed Griñán-Ferré C, Bellver-Sanchis A, Izquierdo V, Corpas R, Roig-Soriano J, Chillón M, Andres-Lacueva C, Somogyvári M, Sőti C, Sanfeliu C, Pallàs M (2021) The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: from antioxidant to epigenetic therapy. Ageing Res Rev 67:101271. https://​doi.​org/​10.​1016/​j.​arr.​2021.​101271CrossRefPubMed
go back to reference Gulyás B, Pavlova E, Kása P, Gulya K, Bakota L, Várszegi S, Keller E, Horváth MC, Nag S, Hermecz I (2011) Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11 C]-L-deprenyl using whole hemisphere autoradiography. Neurochem Int 58(1):60–68CrossRefPubMed Gulyás B, Pavlova E, Kása P, Gulya K, Bakota L, Várszegi S, Keller E, Horváth MC, Nag S, Hermecz I (2011) Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11 C]-L-deprenyl using whole hemisphere autoradiography. Neurochem Int 58(1):60–68CrossRefPubMed
go back to reference Jalilian F, Moieni-Arya M, Hosseinzadeh L, Shokoohinia Y (2022) Oxypeucedanin and isoimperatorin extracted from Prangos Ferulacea (L.) Lindl protect PC12 pheochromocytoma cells from oxidative stress and apoptosis induced by doxorubicin. Res Pharm Sci 17(1):12CrossRefPubMed Jalilian F, Moieni-Arya M, Hosseinzadeh L, Shokoohinia Y (2022) Oxypeucedanin and isoimperatorin extracted from Prangos Ferulacea (L.) Lindl protect PC12 pheochromocytoma cells from oxidative stress and apoptosis induced by doxorubicin. Res Pharm Sci 17(1):12CrossRefPubMed
go back to reference Lee J-S, Kim H-G, Han J-M, Kim D-W, Yi M-H, Son S-W, Kim Y-A, Lee J-S, Choi M-K, Son C-G (2014) Ethanol extract of Astragali Radix and Salviae Miltiorrhizae Radix, Myelophil, exerts anti-amnesic effect in a mouse model of scopolamine-induced memory deficits. J Ethnopharmacol 153(3):782–792CrossRefPubMed Lee J-S, Kim H-G, Han J-M, Kim D-W, Yi M-H, Son S-W, Kim Y-A, Lee J-S, Choi M-K, Son C-G (2014) Ethanol extract of Astragali Radix and Salviae Miltiorrhizae Radix, Myelophil, exerts anti-amnesic effect in a mouse model of scopolamine-induced memory deficits. J Ethnopharmacol 153(3):782–792CrossRefPubMed
go back to reference Lorigooini Z, Koravand M, Haddadi H, Rafieian-Kopaei M, Shirmardi HA, Hosseini Z (2019) A review of botany, phytochemical and pharmacological properties of Ferulago Angulata. Toxin Rev 38(1):13–20CrossRef Lorigooini Z, Koravand M, Haddadi H, Rafieian-Kopaei M, Shirmardi HA, Hosseini Z (2019) A review of botany, phytochemical and pharmacological properties of Ferulago Angulata. Toxin Rev 38(1):13–20CrossRef
go back to reference Mirzapour S, Rafieirad M, Rouhi L (2015) Hydroalcoholic extract of ferulago angulata improves memory and pain in brain hypoperfusion ischemia in rats. Jundishapur J Nat Pharm Prod, 10(1) Mirzapour S, Rafieirad M, Rouhi L (2015) Hydroalcoholic extract of ferulago angulata improves memory and pain in brain hypoperfusion ischemia in rats. Jundishapur J Nat Pharm Prod, 10(1)
go back to reference Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11(1):47–60CrossRefPubMed Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11(1):47–60CrossRefPubMed
go back to reference Rebe RN, Lembe JT, Nyayi SDG, Ngatanko HHA, Wado EK, Wanda K, Ndinteh GJM, Njamen DT, Zingue D, S., Foyet HS (2023) Estrogenic and anti-amnesic potential of Millettia griffoniana Baill. (Fabaceae) ethanolic extract on scopolamine-induced memory impairment in ovariectomized Wistar rats [Article]. J Ethnopharmacol 309. Article 116325. https://doi.org/10.1016/j.jep.2023.116325 Rebe RN, Lembe JT, Nyayi SDG, Ngatanko HHA, Wado EK, Wanda K, Ndinteh GJM, Njamen DT, Zingue D, S., Foyet HS (2023) Estrogenic and anti-amnesic potential of Millettia griffoniana Baill. (Fabaceae) ethanolic extract on scopolamine-induced memory impairment in ovariectomized Wistar rats [Article]. J Ethnopharmacol 309. Article 116325. https://​doi.​org/​10.​1016/​j.​jep.​2023.​116325
go back to reference San Tang K (2019) The cellular and molecular processes associated with scopolamine-induced memory deficit: a model of Alzheimer’s biomarkers. Life Sci 233:116695CrossRef San Tang K (2019) The cellular and molecular processes associated with scopolamine-induced memory deficit: a model of Alzheimer’s biomarkers. Life Sci 233:116695CrossRef
go back to reference Schedin-Weiss S, Inoue M, Hromadkova L, Teranishi Y, Yamamoto NG, Wiehager B, Bogdanovic N, Winblad B, Sandebring-Matton A, Frykman S, Tjernberg LO (2017) Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels. Alzheimer’s Res Therapy 9(1). Article 57. https://doi.org/10.1186/s13195-017-0279-1 Schedin-Weiss S, Inoue M, Hromadkova L, Teranishi Y, Yamamoto NG, Wiehager B, Bogdanovic N, Winblad B, Sandebring-Matton A, Frykman S, Tjernberg LO (2017) Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels. Alzheimer’s Res Therapy 9(1). Article 57. https://​doi.​org/​10.​1186/​s13195-017-0279-1
go back to reference Sepand MR, Soodi M, Hajimehdipoor H, Soleimani M, Sahraei E (2013) Comparison of neuroprotective effects of Melissa officinalis Total Extract and its acidic and non-acidic fractions against a β-Induced toxicity. Iran J Pharm Res 12(2):415–423PubMedPubMedCentral Sepand MR, Soodi M, Hajimehdipoor H, Soleimani M, Sahraei E (2013) Comparison of neuroprotective effects of Melissa officinalis Total Extract and its acidic and non-acidic fractions against a β-Induced toxicity. Iran J Pharm Res 12(2):415–423PubMedPubMedCentral
go back to reference Skalicka-Woźniak K, Orhan IE, Cordell GA, Nabavi SM, Budzyńska B (2016) Implication of coumarins towards central nervous system disorders. Pharmacol Res 103:188–203CrossRefPubMed Skalicka-Woźniak K, Orhan IE, Cordell GA, Nabavi SM, Budzyńska B (2016) Implication of coumarins towards central nervous system disorders. Pharmacol Res 103:188–203CrossRefPubMed
go back to reference Soodi M, Hajimehdipoor H, Ataei N, Akbari S (2016a) Study of the protective effects of seven iranian medicinal plant extracts against beta-amyloid induced cytotoxicity in PC12 cells. Pathobiology Res 19(3):45–58 Soodi M, Hajimehdipoor H, Ataei N, Akbari S (2016a) Study of the protective effects of seven iranian medicinal plant extracts against beta-amyloid induced cytotoxicity in PC12 cells. Pathobiology Res 19(3):45–58
go back to reference Soodi M, Saeidnia S, Sharifzadeh M, Hajimehdipoor H, Dashti A, Sepand MR, Moradi S (2016b) Satureja Bachtiarica ameliorate beta-amyloid induced memory impairment, oxidative stress and cholinergic deficit in animal model of Alzheimer’s disease. Metab Brain Dis 31(2):395–404CrossRefPubMed Soodi M, Saeidnia S, Sharifzadeh M, Hajimehdipoor H, Dashti A, Sepand MR, Moradi S (2016b) Satureja Bachtiarica ameliorate beta-amyloid induced memory impairment, oxidative stress and cholinergic deficit in animal model of Alzheimer’s disease. Metab Brain Dis 31(2):395–404CrossRefPubMed
Metadata
Title
Ferulago Angulata methanolic extract ameliorates scopolamine-induced memory impairment through the inhibition of hippocampal monoamine oxidase activity
Authors
Samaneh hajimohammadi
Maliheh Soodi
Homa Hajimehdipoor
Salma Sefidbakht
Niloofar Mashhadi sharif
Publication date
09-05-2024
Publisher
Springer US
Published in
Metabolic Brain Disease / Issue 5/2024
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-024-01353-4

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