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27-09-2024 | Alzheimer's Disease | Case Report

Amyloid related imaging abnormalities in the emergency setting

Authors: Jan Czerminski, Supriya Khatri, Balaji Rao

Published in: Emergency Radiology

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Abstract

Since the 2021 FDA approval of the first monoclonal antibody (MAB) therapy for Alzheimer's disease (AD), treatment has progressed from symptom management to targeting and reducing amyloid β plaque burden. While these therapies offer hope of altering the disease course, they come with risks, such as amyloid-related imaging abnormalities (ARIA), which include ARIA-E (edema and effusion) and ARIA-H (hemorrhage). This report details the case of a 64-year-old woman undergoing donanemab treatment who developed severe ARIA, characterized by extensive vasogenic edema and multiple microhemorrhages. The increasing use of MABs necessitates heightened awareness and expertise among emergency radiologists to identify findings of ARIA effectively, ensuring timely and appropriate care for patients undergoing these novel therapies.

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Literature
Metadata
Title
Amyloid related imaging abnormalities in the emergency setting
Authors
Jan Czerminski
Supriya Khatri
Balaji Rao
Publication date
27-09-2024
Publisher
Springer International Publishing
Published in
Emergency Radiology
Print ISSN: 1070-3004
Electronic ISSN: 1438-1435
DOI
https://doi.org/10.1007/s10140-024-02286-2