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Current Cardiology Reports

Alteration of Essential Cell Function by Ultrasound-Targeted Microbubble Cavitation

  • 01-12-2025
  • Echocardiography (JM Gardin and AH Waller, Section Editors)
Published in:
Authors
Anurag N. Paranjape
Xucai Chen
Flordeliza S. Villanueva
Published in
Current Cardiology Reports | Issue 1/2025

Abstract

Purpose of Review

Ultrasound-targeted microbubble cavitation (UTMC) has emerged as a transformative non-invasive technology in diagnostic imaging, therapy, and targeted gene and drug delivery. As UTMC advances toward clinical translation, understanding its impact on fundamental cellular functions is essential.

Recent Findings

Recent studies on UTMC have provided insights into its effects on biological processes. These include transient membrane opening and resealing (sonoporation), calcium ion (Ca2+) influx, generation of free radicals, nitric oxide synthesis, cytoskeletal remodeling, inter-endothelial gap formation, gene expression changes, and neuroinflammation.

Summary

This review explores the mechanisms underlying UTMC, with a focus on ultrasound-targeted microbubble cavitation and its bioeffects on cellular function. We examine the molecular processes induced by cavitation, including sonoporation and Ca2+ influx, and highlight their effects on key biological processes.
Title
Alteration of Essential Cell Function by Ultrasound-Targeted Microbubble Cavitation
Authors
Anurag N. Paranjape
Xucai Chen
Flordeliza S. Villanueva
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 1/2025
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-025-02278-9
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Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
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Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME