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Published in: Indian Journal of Otolaryngology and Head & Neck Surgery 2/2022

21-10-2021 | Allergic Rhinitis | Original Article

The Long-Term Effect of Vitamin D Supplementation on Quality of Life in Persistent (Perennial) Allergic Rhinitis Patients

Authors: Prazwal Shrestha, Jasmine Kaur, Yeshdeep Gupta, Hitesh Verma

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery | Issue 2/2022

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Abstract

Vitamin D is one of the thoroughly studied risk factors in the pathogenesis of allergic rhinitis (AR). Low serum level of vitamin D is well documented in the urban population of India. The supplementation policy of vitamin D is not uniform among practitioners. The study aims to assess the impact of vitamin D deficiency on AR & long-term quality of life in perennial AR patients with low vitamin D levels after its supplementation in the urban population. The policy for evaluation of serum level of vitamin D & its supplementation in deficit patients in AR is not uniform in our hospital. The data was extracted from the hospital records & the patients came to OPD in the year 2018–2019. Inclusion criteria were the clinical diagnosis (ARIA guideline) of the perennial form of AR where vitamin D assessment was performed before prescribing treatment & the patients received a complete course of vitamin D as per the recommendation followed in our Institute. The patients received oral antihistaminic & topical steroids based nasal spray and were clubbed together as a control group whereas, in the study group, the patients were pooled together who received vitamin D supplementation along with oral antihistaminic & topical steroids based nasal spray. Pre-treatment & post-treatment (at 8 weeks, 6 months, and 12 months) SNOT-22 scores were obtained from the records. The data were analyzed statistically using repeated measures ANOVA test. The study showed a significant decrease in the SNOT-22 score in both Groups in comparison to pre-treatment scores, but post-treatment group comparison was not found statistically significant at each point of comparison. The scores were found on the lower side in the study group at the initial two evaluation points whereas it was higher at the third point of evaluation. This study showed the additional therapeutic effect of vitamin D supplementation as an adjunct in the treatment of perennial AR patients but the effectiveness of the treatment does not last forever so maintenance therapy is required especially in areas following the Indian lifestyle.
Literature
1.
go back to reference Bousquet J, Van Cauwenberge P, Khaltaev N (2001) Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 108(5 suppl):S147-334 CrossRef Bousquet J, Van Cauwenberge P, Khaltaev N (2001) Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 108(5 suppl):S147-334 CrossRef
2.
go back to reference Maurer M, Zuberbier T (2007) Undertreatment of rhinitis symptoms in Europe: findings from a cross-sectional questionnaire survey. Allergy 62:1057–1063 CrossRef Maurer M, Zuberbier T (2007) Undertreatment of rhinitis symptoms in Europe: findings from a cross-sectional questionnaire survey. Allergy 62:1057–1063 CrossRef
3.
go back to reference Bousquet J, Neukirch F, Bousquet PJ et al (2006) Severity and impairment of allergic rhinitis in patients consulting in primary care. J Allergy Clin Immunol 117:158–162 CrossRef Bousquet J, Neukirch F, Bousquet PJ et al (2006) Severity and impairment of allergic rhinitis in patients consulting in primary care. J Allergy Clin Immunol 117:158–162 CrossRef
4.
go back to reference Greiner AN, Hellings PW, Rotiroti G, Scadding GK (2011) Allergic rhinitis. Lancet 378(9809):2112–2122 CrossRef Greiner AN, Hellings PW, Rotiroti G, Scadding GK (2011) Allergic rhinitis. Lancet 378(9809):2112–2122 CrossRef
5.
go back to reference Restimulia L, Pawarti DR, Ekorini HM (2018) The relationship between serum vitamin D levels with allergic rhinitis incidence and total nasal symptom score in allergic rhinitis patients. Open Access Maced J Med Sci 6(8):1405–1409 CrossRef Restimulia L, Pawarti DR, Ekorini HM (2018) The relationship between serum vitamin D levels with allergic rhinitis incidence and total nasal symptom score in allergic rhinitis patients. Open Access Maced J Med Sci 6(8):1405–1409 CrossRef
6.
go back to reference Kamen D, Tangpricha V (2010) Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med 88:441–450 CrossRef Kamen D, Tangpricha V (2010) Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med 88:441–450 CrossRef
7.
go back to reference Mora JR, Iwata M, von Andrian UH (2008) Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 8:685–698 CrossRef Mora JR, Iwata M, von Andrian UH (2008) Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 8:685–698 CrossRef
8.
go back to reference Aparna P, Muthathal S, Nongkynrih B, Gupta SK (2018) Vitamin D deficiency in India. J Family Med Prim Care 7(2):324–330 CrossRef Aparna P, Muthathal S, Nongkynrih B, Gupta SK (2018) Vitamin D deficiency in India. J Family Med Prim Care 7(2):324–330 CrossRef
12.
go back to reference Jung JW, Kim JY, Cho SH et al (2013) Allergic rhinitis and serum 25-hydroxyvitamin D level in Korean adults. Ann Allergy Asthma Immunol 111(5):352–357 CrossRef Jung JW, Kim JY, Cho SH et al (2013) Allergic rhinitis and serum 25-hydroxyvitamin D level in Korean adults. Ann Allergy Asthma Immunol 111(5):352–357 CrossRef
13.
go back to reference Arshi S, Ghalehbaghi B, Kamrava S-K et al (2012) Vitamin D serum levels in allergic rhinitis: any difference from normal population? Asia Pac Allergy 2(1):45–48 CrossRef Arshi S, Ghalehbaghi B, Kamrava S-K et al (2012) Vitamin D serum levels in allergic rhinitis: any difference from normal population? Asia Pac Allergy 2(1):45–48 CrossRef
14.
go back to reference Tian HQ, Cheng L (2017) The role of vitamin D in allergic rhinitis. Asia Pac Allergy 7(2):65–73 CrossRef Tian HQ, Cheng L (2017) The role of vitamin D in allergic rhinitis. Asia Pac Allergy 7(2):65–73 CrossRef
15.
go back to reference Cheng HM, Kim S, Park GH, Chang SE, Bang S, Won CH et al (2014) Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population. J Allergy Clin Immunol 133(4):1048–1055 CrossRef Cheng HM, Kim S, Park GH, Chang SE, Bang S, Won CH et al (2014) Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population. J Allergy Clin Immunol 133(4):1048–1055 CrossRef
16.
go back to reference Wjst M, Hypponen E (2007) Vitamin D serum levels and allergic rhinitis. Allergy 62:1085–1086 CrossRef Wjst M, Hypponen E (2007) Vitamin D serum levels and allergic rhinitis. Allergy 62:1085–1086 CrossRef
20.
go back to reference Modh D, Katarkar A, Jain A et al (2014) Role of vitamin D supplementation in Allergic rhinitis. Indian J Allergy Asthma Immunol 28:35–39 CrossRef Modh D, Katarkar A, Jain A et al (2014) Role of vitamin D supplementation in Allergic rhinitis. Indian J Allergy Asthma Immunol 28:35–39 CrossRef
21.
go back to reference Bhardwaj B, Singh J (2021) Efficacy of vitamin D supplementation in allergic rhinitis. Indian J Otolaryngol Head Neck Surg 73(2):152–159 CrossRef Bhardwaj B, Singh J (2021) Efficacy of vitamin D supplementation in allergic rhinitis. Indian J Otolaryngol Head Neck Surg 73(2):152–159 CrossRef
23.
24.
go back to reference Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM (2011) Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 96(7):1911–30. doi: https://​doi.​org/​10.​1210/​jc.​2011-0385. Epub 2011 Jun 6. Erratum in: J Clin Endocrinol Metab. 2011 Dec;96(12):3908. PMID: 21646368 Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM (2011) Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 96(7):1911–30. doi: https://​doi.​org/​10.​1210/​jc.​2011-0385. Epub 2011 Jun 6. Erratum in: J Clin Endocrinol Metab. 2011 Dec;96(12):3908. PMID: 21646368
26.
go back to reference Bener A, Ehlayel MS, Bener HZ, Hamid Q (2014) The impact of Vitamin D deficiency on asthma, allergic rhinitis and wheezing in children: an emerging public health problem. J Fam Community Med 21:154–161 CrossRef Bener A, Ehlayel MS, Bener HZ, Hamid Q (2014) The impact of Vitamin D deficiency on asthma, allergic rhinitis and wheezing in children: an emerging public health problem. J Fam Community Med 21:154–161 CrossRef
28.
go back to reference Majak P, Olszowiec-Chlebna M, Smejda K, Stelmach I (2011) Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol 127:1294–1296 CrossRef Majak P, Olszowiec-Chlebna M, Smejda K, Stelmach I (2011) Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol 127:1294–1296 CrossRef
29.
go back to reference Li-Ng M, Aloia JF, Pollack S et al (2009) A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections. Epidemiol Infect 137:1396–1404 CrossRef Li-Ng M, Aloia JF, Pollack S et al (2009) A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections. Epidemiol Infect 137:1396–1404 CrossRef
30.
go back to reference Chen B, Qu S, Li M, Ye L, Zhang S, Qin T, Fan H (2017) Effects of 1,25-dihydroxyvitamin D3 in an ovalbumin-induced allergic rhinitis model. Int Immunopharmacol 47:182–189 CrossRef Chen B, Qu S, Li M, Ye L, Zhang S, Qin T, Fan H (2017) Effects of 1,25-dihydroxyvitamin D3 in an ovalbumin-induced allergic rhinitis model. Int Immunopharmacol 47:182–189 CrossRef
31.
go back to reference Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF et al (2006) Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoidresistant asthma patients. J Clin Invest 116:146–155 CrossRef Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF et al (2006) Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoidresistant asthma patients. J Clin Invest 116:146–155 CrossRef
32.
go back to reference Yawn J, Lawrence LA, Carroll WW, Mulligan JK (2015) Vitamin D for the treatment of respiratory diseases: Is it the end or just the beginning? J Steroid Biochem Mol Biol 148:326–337 CrossRef Yawn J, Lawrence LA, Carroll WW, Mulligan JK (2015) Vitamin D for the treatment of respiratory diseases: Is it the end or just the beginning? J Steroid Biochem Mol Biol 148:326–337 CrossRef
Metadata
Title
The Long-Term Effect of Vitamin D Supplementation on Quality of Life in Persistent (Perennial) Allergic Rhinitis Patients
Authors
Prazwal Shrestha
Jasmine Kaur
Yeshdeep Gupta
Hitesh Verma
Publication date
21-10-2021
Publisher
Springer India
Published in
Indian Journal of Otolaryngology and Head & Neck Surgery / Issue 2/2022
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-021-02938-6

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