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Open Access 07-12-2024 | Albuminuria | Original Article

Vanadium exposure and kidney markers in a pediatric population: a cross-sectional study

Authors: Elodia Rojas-Lima, Manolo Ortega-Romero, Octavio Gamaliel Aztatzi-Aguilar, Juan Carlos Rubio-Gutiérrez, Juana Narváez-Morales, Mariela Esparza-García, Pablo Méndez-Hernández, Mara Medeiros, Olivier Christophe Barbier

Published in: Pediatric Nephrology | Issue 5/2025

Abstract

Background

Anthropogenic vanadium (V) emissions and exposure in the general population have recently increased. Experimental studies have shown that V is a nephrotoxic agent, but little is known about its effects on human kidney health. This work evaluated the association between urinary V concentrations with early kidney damage biomarkers and function in a pediatric population without any disease diagnosed.

Methods

A cross-sectional study was carried out and included 914 healthy subjects and determined urinary V concentrations, glomerular filtration rate (eGFR), albumin–creatinine ratio (ACR), and the presence of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in urine. We evaluated the V effect using linear and logistic regression models adjusted by confounders.

Results

Subjects found in the second and third tertiles of V showed an increase in urinary log-NGAL levels (βT2 vs. T1 = 0.39; 95% CI 0.14, 0.64, and βT3 vs. T1 = 1.04; 95% CI 0.75, 1.34) and log-KIM-1(βT2 vs. T1 = 0.25; 95% CI 0.04, 0.45 and βT3 vs. T1 = 0.39; 95% CI 0.15, 0.63); in addition, subjects in the third tertile had a positive and significant association with ACR (ORT3 vs. T1 = 1.96; 95% CI 1.29, 2.97) and increased in eGFR (βT3 vs. T1 = 3.98, 95% CI 0.39, 7.58), compared with subjects in the first tertile.

Conclusions

Our study reports the effect of V on kidney markers in a healthy pediatric population. It could be related to tubulointerstitial lesions and function abnormalities.

Graphical Abstract

Available only for authorised users

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Title: Vanadium exposure and kidney markers in a pediatric population: a cross-sectional study
Authors: Elodia Rojas-Lima
Manolo Ortega-Romero
Octavio Gamaliel Aztatzi-Aguilar
Juan Carlos Rubio-Gutiérrez
Juana Narváez-Morales
Mariela Esparza-García
Pablo Méndez-Hernández
Mara Medeiros
Olivier Christophe Barbier
Publication date: 07-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Albuminuria
Biomarkers
Kidney Injury
Published in: Pediatric Nephrology / Issue 5/2025
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-024-06561-9

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Vanadium exposure and kidney markers in a pediatric population: a cross-sectional study

Abstract

Background

Methods

Results

Conclusions

Graphical Abstract

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Abstract

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Conclusions

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