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International Journal of Hematology
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17-07-2024 | AL Amyloidosis | Letter to the Editor

Characteristic and recurrent pathophysiological features of non-duodenal follicular lymphoma of the small intestine

Authors: Yosuke Matsumoto, Tetsuya Masuda, Mihoko Yoshida, Kazuho Shimura, Hiroto Kaneko, Masafumi Taniwaki

Published in: International Journal of Hematology | Issue 3/2024

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Excerpt

We previously reported a case of follicular lymphoma (FL) with plasmacytic differentiation (PCD) (FL-PCD) in the ileum as a first case of amyloid light chain (AL) amyloidosis associated with FL [1]. Recently, Tajima et al. reported a case of FL-PCD associated with AL amyloidosis in the jejunum [2]. Both cases had the following pathophysiological features in common:
1.
The histological grade of FL was grade 1.
 
2.
FL was accompanied by PCD. Cytogenetic studies showed that the plasma cells originated not from reactive lymphocytes but rather from neoplastic FL cells. These plasma cells distributed in interfollicular lesions. In both cases, both FL cells and infiltrating plasma cells were immunohistochemically positive for BCL2.
 
3.
Localized lambda AL amyloid was deposited adjacent to neoplastic lymphoid follicles.
 
4.
Both patients were female.
 
…
Literature
1.
Matsumoto Y, Masuda T, Nishimura A, Horie H, Harada K, Yoshida M, et al. A case of AL amyloidosis associated with follicular lymphoma with plasmacytic differentiation. Int J Hematol. 2020;111:317–23.CrossRefPubMed
2.
Tajima K, Nomura T, Terada T, Okuyama S, Kumagai H, Maeda K, et al. Solitary follicular lymphoma with plasmacytic differentiation associated with localized AL amyloidosis in the jejunum. Ann Hematol. 2023;102:1625–7.CrossRefPubMed
3.
Gibson SE, Liu YC, Yatsenko SA, Barasch NJ, Swerdlow SH. Histopathologic, immunophenotypic, and mutational landscape of follicular lymphomas with plasmacytic differentiation. Mod Pathol. 2022;35:60–8.CrossRefPubMed
4.
Ohnishi N, Takata K, Miyata-Takata T, Sato Y, Tari A, Gion Y, et al. CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine. Cancer Sci. 2016;107:1687–95.CrossRefPubMedPubMedCentral
Metadata
Title
Characteristic and recurrent pathophysiological features of non-duodenal follicular lymphoma of the small intestine
Authors
Yosuke Matsumoto
Tetsuya Masuda
Mihoko Yoshida
Kazuho Shimura
Hiroto Kaneko
Masafumi Taniwaki
Publication date
17-07-2024
Publisher
Springer Nature Singapore
Published in
International Journal of Hematology / Issue 3/2024
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-024-03820-1

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