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Current Hematologic Malignancy Reports

Monoclonal Gammopathy-Associated Neuropathy

Published in:
Authors
Shayna Sarosiek
Christopher T. Doughty
Jorge J. Castillo
Published in
Current Hematologic Malignancy Reports | Issue 1/2025

Abstract

Purpose of Review

Peripheral neuropathy (PN) is more commonly seen in individuals with monoclonal gammopathies, especially in patients with an IgM monoclonal gammopathy or Waldenström macroglobulinemia.

Recent Findings

There are multiple potential ways that the paraprotein may result in peripheral neuropathy. The diagnosis and management of monoclonal gammopathy-associated PN are challenging and necessitate a concerted effort between the hematologist/oncologist and the neurologist.

Summary

This review describes the most common PN syndromes associated with monoclonal gammopathy, such as anti-myelin-associated glycoprotein neuropathy, light chain amyloidosis, cryoglobulinemia, POEMS, CANOMAD, and others. We also review the therapies used to treat these conditions.
Title
Monoclonal Gammopathy-Associated Neuropathy
Authors
Shayna Sarosiek
Christopher T. Doughty
Jorge J. Castillo
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Hematologic Malignancy Reports / Issue 1/2025
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-024-00745-8
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