Clinical and pathological characteristics of immune checkpoint inhibitor-related fulminant myocarditis
- Open Access
- 21-11-2024
- Adverse Effects of Cancer Therapy
- Case Report
Published in:
- Authors
- Ryo Izumi
- Toru Hashimoto
- Hiroshi Kisanuki
- Kei Ikuta
- Wataru Otsuru
- Soshun Asakawa
- Shoei Yamamoto
- Kayo Misumi
- Takeo Fujino
- Keisuke Shinohara
- Shouji Matsushima
- Kazuya Hosokawa
- Shunsuke Katsuki
- Taro Mori
- Mikiko Hashisako
- Yuki Tateishi
- Takeshi Iwasaki
- Yoshinao Oda
- Shintaro Kinugawa
- Kohtaro Abe
- Published in
- Cardio-Oncology | Issue 1/2024
Abstract
The advent of immune checkpoint inhibitors (ICIs) has significantly improved cancer treatment. With the increasing use of ICIs, ICI-related myocarditis has been recognized. However, an evidence-based therapeutic strategy has not been established because of the limited knowledge on ICI-related myocarditis. Here, we present four cases of ICI-related fulminant myocarditis (FM). Three of the four cases resulted in fatal outcomes despite aggressive treatment with mechanical circulatory support and immunosuppressive therapy with corticosteroids. Given the poor prognosis of ICI-FM, the establishment of rapid and adequate therapeutic interventions on the basis of clinical and pathological evaluation is imperative.
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- Title
- Clinical and pathological characteristics of immune checkpoint inhibitor-related fulminant myocarditis
- Authors
-
Ryo Izumi
Toru Hashimoto
Hiroshi Kisanuki
Kei Ikuta
Wataru Otsuru
Soshun Asakawa
Shoei Yamamoto
Kayo Misumi
Takeo Fujino
Keisuke Shinohara
Shouji Matsushima
Kazuya Hosokawa
Shunsuke Katsuki
Taro Mori
Mikiko Hashisako
Yuki Tateishi
Takeshi Iwasaki
Yoshinao Oda
Shintaro Kinugawa
Kohtaro Abe
- Publication date
- 21-11-2024
- Publisher
- BioMed Central
- Keywords
-
Adverse Effects of Cancer Therapy
Checkpoint Inhibitors
Myocarditis
Cardiogenic Shock
Kidney Cancer
Prostate Cancer
Lung Cancer
ECMO
ECMO
Ventricular Tachycardia
Cardiogenic Shock
Intra-Aortic Balloon
Electrocardiography
Electrocardiography
CSF Drainage - Published in
-
Cardio-Oncology / Issue 1/2024
Electronic ISSN: 2057-3804 - DOI
- https://doi.org/10.1186/s40959-024-00288-0
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