Skip to main content
Top
Published in: Infection 4/2022

03-02-2022 | Adalimumab | Case Report

Meningoencephalitis caused by Fusarium proliferatum: an unusual case

Authors: Ilad Alavi Darazam, M.D., Guive Sharifi, Elena Jamali, Sadegh Khodavaisy, Farid Javandoust Gharehbagh, Atousa Hakamifard

Published in: Infection | Issue 4/2022

Login to get access

Abstract

Meningoencephalitis can be a diagnostic dilemma and one of its etiology are infectious causes including fungal agents. Fusarium species have attracted much attention as one of the invasive fungal infections. Major clinical manifestations of infections due to Fusarium spp. are broad such as keratitis, endophthalmitis, sino-pulmonary and central nervous system (CNS) infections. However, CNS fusariosis is rare and often happens due to hematogenous dissemination from other sites. Herein, we describe an unusual case of meningoencephalitis caused by Fusarium proliferatum, in a patient with rheumatoid arthritis.
Literature
1.
go back to reference Nucci M, Anaissie E. Cutaneous infection by Fusarium species in healthy and immunocompromised hosts: implications for diagnosis and management. Clin Infect Dis. 2002;35(8):909–20.CrossRef Nucci M, Anaissie E. Cutaneous infection by Fusarium species in healthy and immunocompromised hosts: implications for diagnosis and management. Clin Infect Dis. 2002;35(8):909–20.CrossRef
2.
go back to reference Nelson PE, Dignani MC, Anaissie EJ. Taxonomy, biology, and clinical aspects of Fusarium species. Clin Microbiol Rev. 1994;7(4):479–504.CrossRef Nelson PE, Dignani MC, Anaissie EJ. Taxonomy, biology, and clinical aspects of Fusarium species. Clin Microbiol Rev. 1994;7(4):479–504.CrossRef
3.
go back to reference Sampathkumar P, Paya CV. Fusarium infection after solid-organ transplantation. Clin Infect Dis. 2001;32(8):1237–40.CrossRef Sampathkumar P, Paya CV. Fusarium infection after solid-organ transplantation. Clin Infect Dis. 2001;32(8):1237–40.CrossRef
4.
go back to reference Garcia RR, Min Z, Narasimhan S, Bhanot N. Fusarium brain abscess: case report and literature review. Mycoses. 2015;58(1):22–6.CrossRef Garcia RR, Min Z, Narasimhan S, Bhanot N. Fusarium brain abscess: case report and literature review. Mycoses. 2015;58(1):22–6.CrossRef
5.
go back to reference O’Donnell K, Sutton DA, Rinaldi MG, Sarver BA, Balajee SA, Schroers HJ, Summerbell RC, Robert VA, Crous PW, Zhang N, Aoki T, Jung K, Park J, Lee YH, Kang S, Park B, Geiser DM. Internet-accessible DNA sequence database for identifying fusaria from human and animal infections. J Clin Microbiol. 2010;48:3708–18.CrossRef O’Donnell K, Sutton DA, Rinaldi MG, Sarver BA, Balajee SA, Schroers HJ, Summerbell RC, Robert VA, Crous PW, Zhang N, Aoki T, Jung K, Park J, Lee YH, Kang S, Park B, Geiser DM. Internet-accessible DNA sequence database for identifying fusaria from human and animal infections. J Clin Microbiol. 2010;48:3708–18.CrossRef
6.
go back to reference Klindworth A, Pruesse E, Schweer T, Peplies J, Quast C, Horn M, et al. Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies. Nucleic Acids Res. 2013;41(1):e1.CrossRef Klindworth A, Pruesse E, Schweer T, Peplies J, Quast C, Horn M, et al. Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies. Nucleic Acids Res. 2013;41(1):e1.CrossRef
7.
8.
9.
11.
go back to reference Ruhnke M, Cornely OA, Schmidt-Hieber M, Alakel N, Boell B, Buchheidt D, et al. Treatment of invasive fungal diseases in cancer patients—Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Mycoses. 2020;63(7):653–82.CrossRef Ruhnke M, Cornely OA, Schmidt-Hieber M, Alakel N, Boell B, Buchheidt D, et al. Treatment of invasive fungal diseases in cancer patients—Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Mycoses. 2020;63(7):653–82.CrossRef
12.
go back to reference Antonissen G, Martel A, Pasmans F, Ducatelle R, Verbrugghe E, Vandenbroucke V, et al. The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases. Toxins. 2014;6(2):430–52.CrossRef Antonissen G, Martel A, Pasmans F, Ducatelle R, Verbrugghe E, Vandenbroucke V, et al. The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases. Toxins. 2014;6(2):430–52.CrossRef
13.
go back to reference McCarthy M, Rosengart A, Schuetz AN, Kontoyiannis DP, Walsh TJ. Mold infections of the central nervous system. N Engl J Med. 2014;371(2):150–60.CrossRef McCarthy M, Rosengart A, Schuetz AN, Kontoyiannis DP, Walsh TJ. Mold infections of the central nervous system. N Engl J Med. 2014;371(2):150–60.CrossRef
14.
go back to reference Anten S, Heddema ER, Visser O, Zweegman AS. Cerebral fungal abscess in a patient with acute promyelocytic leukaemia. Br J Haematol. 2008;140(3):253.CrossRef Anten S, Heddema ER, Visser O, Zweegman AS. Cerebral fungal abscess in a patient with acute promyelocytic leukaemia. Br J Haematol. 2008;140(3):253.CrossRef
15.
go back to reference Agamanolis DP, Kalwinsky DK, Krill CE Jr, Dasu S, Halasa B, Galloway PG. Fusarium meningoencephalitis in a child with acute leukemia. Neuropediatrics. 1991;22(02):110–2.CrossRef Agamanolis DP, Kalwinsky DK, Krill CE Jr, Dasu S, Halasa B, Galloway PG. Fusarium meningoencephalitis in a child with acute leukemia. Neuropediatrics. 1991;22(02):110–2.CrossRef
16.
go back to reference Namboothiri PS, Nair SN, Vijayan K, Visweswaran VK. Disseminated Fusarium oxysporum neurospinal infection. Indian J Orthop. 2014;48(2):220–2.CrossRef Namboothiri PS, Nair SN, Vijayan K, Visweswaran VK. Disseminated Fusarium oxysporum neurospinal infection. Indian J Orthop. 2014;48(2):220–2.CrossRef
17.
go back to reference Tortorano AM, Richardson M, Roilides E, Van Diepeningen A, Caira M, Munoz P, Johnson E, Meletiadis J, Pana ZD, Lackner M, Verweij P. ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others. Clin Microbiol Infect. 2014;20:27–46.CrossRef Tortorano AM, Richardson M, Roilides E, Van Diepeningen A, Caira M, Munoz P, Johnson E, Meletiadis J, Pana ZD, Lackner M, Verweij P. ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others. Clin Microbiol Infect. 2014;20:27–46.CrossRef
18.
go back to reference Lupinetti FM, Giller RH, Trigg ME. Operative treatment of Fusarium fungal infection of the lung. Ann Thorac Surg. 1990;49:991–2.CrossRef Lupinetti FM, Giller RH, Trigg ME. Operative treatment of Fusarium fungal infection of the lung. Ann Thorac Surg. 1990;49:991–2.CrossRef
19.
go back to reference Burmester GR, Mariette X, Montecucco C, Monteagudo-Sáez I, Malaise M, Tzioufas AG, et al. Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial. Ann Rheum Dis. 2007;66(6):732–9.CrossRef Burmester GR, Mariette X, Montecucco C, Monteagudo-Sáez I, Malaise M, Tzioufas AG, et al. Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial. Ann Rheum Dis. 2007;66(6):732–9.CrossRef
20.
go back to reference Salvana EM, Salata RA. Infectious complications associated with monoclonal antibodies and related small molecules. Clin Microbiol Rev. 2009;22(2):274–90.CrossRef Salvana EM, Salata RA. Infectious complications associated with monoclonal antibodies and related small molecules. Clin Microbiol Rev. 2009;22(2):274–90.CrossRef
21.
go back to reference Wallis RS, Broder M, Wong J, Lee A, Hoq L. Reactivation of latent granulomatous infections by infliximab. Clin Infect Dis. 2005;41(13):194–8.CrossRef Wallis RS, Broder M, Wong J, Lee A, Hoq L. Reactivation of latent granulomatous infections by infliximab. Clin Infect Dis. 2005;41(13):194–8.CrossRef
22.
go back to reference Pflugfelder SC, Flynn HW Jr, Zwickey TA, Forster RK, Tsiligianni A, Culbertson WW, Mandelbaum S. Exogenous fungal endophthalmitis. Ophthalmology. 1988;95(1):19–30.CrossRef Pflugfelder SC, Flynn HW Jr, Zwickey TA, Forster RK, Tsiligianni A, Culbertson WW, Mandelbaum S. Exogenous fungal endophthalmitis. Ophthalmology. 1988;95(1):19–30.CrossRef
Metadata
Title
Meningoencephalitis caused by Fusarium proliferatum: an unusual case
Authors
Ilad Alavi Darazam, M.D.
Guive Sharifi
Elena Jamali
Sadegh Khodavaisy
Farid Javandoust Gharehbagh
Atousa Hakamifard
Publication date
03-02-2022
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 4/2022
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-022-01761-7

Other articles of this Issue 4/2022

Infection 4/2022 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Webinar | 06-02-2024 | 20:00 (CET)

Mastering chronic pancreatitis pain: A multidisciplinary approach and practical solutions

Severe pain is the most common symptom of chronic pancreatitis. In this webinar, experts share the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discuss pertinent cases and provide practical suggestions for use within clinical practice.

Sponsored by: Viatris

Developed by: Springer Healthcare