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BMC Geriatrics
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Open Access 01-12-2024 | Acute Respiratory Distress Syndrome | Research

Assessment of bidirectional relationships between frailty and acute respiratory distress syndrome: a bidirectional Mendelian Randomization study

Authors: Yusha Chen, Xuefei Zhang, Yuxi Chen, Zhaohui Tong

Published in: BMC Geriatrics | Issue 1/2024

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Abstract

Background

While previous observational studies have suggested a link between frailty and acute respiratory distress syndrome (ARDS), the causality of this connection remains unclear. The objective of this study was to explore the potential bidirectional causal links between frailty and ARDS.

Methods

A two-sample univariable Mendelian randomization (MR) was performed to assess the causal relationship between frailty, as defined by frailty index (FI, n = 175,226) and fried frailty score (FFS, n = 386,565), and ARDS. The genome-wide association study (GWAS) data of frailty was from the UK Biobank and the ARDS data was from the FinnGen Database. Univariable MR analyses were conducted using inverse-variance weighted (IVW), weighted median, MR-Egger regression, and robust adjusted profile score (MR. RAPS). We also performed multivariable Mendelian randomization (MVMR) analysis including smoking initiation, alcohol consumption, body mass index (BMI), and cognitive performance.

Results

This bidirectional MR analysis demonstrated no causal effect of FI (OR = 0.96, 95% CI 0.14–6.88) and FFS (OR = 1.95, 95%CI 0.14–28.16) on increased susceptibility of ARDS. Also, no evidence was found for an effect of ARDS on the risk of frailty. The MVMR analysis indicated higher BMI and poorer cognitive performance were associated with increased risk of ARDS.

Conclusions

The outcomes of our analysis imply a probable absence of a direct causal relationship between frailty and susceptibility to ARDS. To reinforce and expand upon these preliminary findings, it is imperative to conduct larger-scale genome-wide association studies.
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Metadata
Title
Assessment of bidirectional relationships between frailty and acute respiratory distress syndrome: a bidirectional Mendelian Randomization study
Authors
Yusha Chen
Xuefei Zhang
Yuxi Chen
Zhaohui Tong
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2024
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-024-05579-w

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