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A 55-year-old man with agranulocytosis was diagnosed with acute myeloid leukemia (AML). Atypical eosinophil granulocytes with large basophil but also small pale, structureless granules were observed, and cells with Auer rods in maturing granulopoiesis were noticed in the bone marrow. Panel A shows a mature granulocyte in peripheral blood with many Auer rods in cytoplasm (Pappenheim stained peripheral blood smear, 1000x; Supplementary Material). Auer rods were visible in the peripheral blood in 8% (4/50) of the mature granulocytes. Panel B shows fluorescence-in-situ-hybridization with inversion 16 [inv(16)(p13q22)] in a bone marrow blast due to rearrangement (split; red and green) of a CBFB copy (1000x) (Fig. 1).
Fig 1.
A Mature granulocyte in peripheral blood with many Auer rods in cytoplasm (Pappenheim stain, 1000x). B Fluorescence-in-situ-hybridization with inversion 16 [inv(16)(p13q22)] in a bone marrow blast (split; red and green; 1000x)
Catch up on all the latest news, guidance and expert opinion from the 2025 ASH annual meeting, including updates in sickle cell disease, multiple myeloma, lymphoma, transplants.
CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.
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