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Open Access 17-06-2024 | Acute Kidney Injury | Case Report

Successful treatment of acute tubulointerstitial nephritis probably due to Benikoji CholesteHelp®, a supplement containing red yeast rice

Authors: Masayuki Maiguma, Masao Kihara, Maki Hamaguchi, Takashi Kobayashi, Koshi Yamada, Miyuki Takagi, Harumi Saeki, Tomohito Gohda, Yusuke Suzuki

Published in: CEN Case Reports

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Abstract

Red yeast rice has been used to produce alcoholic beverages and various fermented foods especially in East Asia. Since around March 2024, there have been many cases of kidney dysfunction in people who have taken certain supplements containing red yeast rice in Japan. We experienced a case of acute kidney injuries induced after taking a supplement containing red yeast rice. A 58-year-old woman was admitted to our hospital due to renal dysfunction suspected to be caused by taking the supplement Benikoji CholesteHelp®, which contains red yeast rice. With elevations of urinary tubular injury markers such as urinary β2-microglobulin and N-acetyl-β-D-glucosaminidase, serum creatinine levels were elevated up to 2.75 mg/dL. A kidney biopsy revealed a diagnosis of tubulointerstitial nephritis with lymphocytic infiltration of the interstitium, tubular atrophy, and interstitial fibrotic changes. After discontinuation of the supplement and initiation of the prednisolone treatment, renal dysfunction rapidly improved. The course of this case suggests tubular damage caused by the supplements containing red yeast rice. For early diagnosis and treatment, it should be noted that even what are regarded as nutritional health supplements can cause renal dysfunction.
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Metadata
Title
Successful treatment of acute tubulointerstitial nephritis probably due to Benikoji CholesteHelp®, a supplement containing red yeast rice
Authors
Masayuki Maiguma
Masao Kihara
Maki Hamaguchi
Takashi Kobayashi
Koshi Yamada
Miyuki Takagi
Harumi Saeki
Tomohito Gohda
Yusuke Suzuki
Publication date
17-06-2024
Publisher
Springer Nature Singapore
Published in
CEN Case Reports
Electronic ISSN: 2192-4449
DOI
https://doi.org/10.1007/s13730-024-00897-9
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