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Open Access 18-12-2023 | Acute Kidney Injury | Original Article

Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark

Authors: Sidse Høyer, Uffe Heide-Jørgensen, Simon Kok Jensen, Mette Nørgaard, Cara Slagle, Stuart Goldstein, Christian Fynbo Christiansen

Published in: Pediatric Nephrology | Issue 6/2024

Abstract

Background

We aimed to examine temporal changes in the annual rate of acute kidney injury (AKI) in Danish children and associated changes in patient characteristics including potential underlying risk factors.

Methods

In this population-based cohort study, we used plasma creatinine measurements from Danish laboratory databases to identify AKI episodes in children aged 0–17 years from 2007 to 2021. For each child, the first AKI episode per calendar year was included. We estimated the annual crude and sex- and age-standardized AKI rate as the number of children with an AKI episode divided by the total number of children as reported by census numbers. Using Danish medical databases, we assessed patient characteristics including potential risk factors for AKI, such as use of nephrotoxic medication, surgery, sepsis, and perinatal factors.

Results

In total, 14,200 children contributed with 16,345 AKI episodes over 15 years. The mean annual AKI rate was 148 (95% CI: 141–155) per 100,000 children. From 2007 to 2021, the annual AKI rate demonstrated minor year-to-year variability without any discernible overall trend. The highest AKI rate was recorded in 2007 at 174 (95% CI: 161–187) per 100,000 children, while the lowest rate occurred in 2012 at 129 (95% CI: 118–140) per 100,000 children. In 2021, the AKI rate was 148 (95% CI: 141–155) per 100,000 children. Characteristics of children with AKI were similar throughout the study period.

Conclusion

The rate of AKI among Danish children was stable from 2007 to 2021 with little variation in patient characteristics over time.

Graphical abstract

Available only for authorised users

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Title: Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark
Authors: Sidse Høyer
Uffe Heide-Jørgensen
Simon Kok Jensen
Mette Nørgaard
Cara Slagle
Stuart Goldstein
Christian Fynbo Christiansen
Publication date: 18-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Acute Kidney Injury
Acute Kidney Injury
Published in: Pediatric Nephrology / Issue 6/2024
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-06246-9

2024 ESC Congress

Springer Medicine

Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark

Abstract

Background

Methods

Results

Conclusion

Graphical abstract

2024 ESC Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Graphical abstract

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