01-12-2024 | Acute Gastroenteritis | Brief Report
Complete genome sequence of a rare recombinant GII.5[P16] norovirus found in Russian Siberia
Authors:
E. Zhirakovskaia, A. Tikunov, B. Kravchuk, N. Tikunova
Published in:
Archives of Virology
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Issue 12/2024
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Abstract
Noroviruses (family Caliciviridae) are common causes of acute gastroenteritis worldwide. Multiple polymerase/capsid combinations have been identified among members of norovirus genogroup GII, at least 10 of which contain GII.P16 polymerase. During hospital-based surveillance (2003–2013) in Russia, we identified eight noroviruses with GII.P16 polymerase – five GII.3[P16], two GII.16[P16], and one GII.5[P16]. This is the first report of the nearly complete genome sequence of a rare recombinant GII.5[P.16] norovirus, which was found in the feces of a child in 2010. Phylogenetic analysis revealed that ORF1 and ORF2/3 of the strain GII.5[P.16]/RUS/Novosibirsk/Nsk-N490/2010 formed separate branches in clusters GII.P16 and GII.5, respectively.