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Current Cardiology Reports

Polypill Strategy in Secondary Cardiovascular Prevention

Published in:
Authors
Alan De la Rosa
Kedzie Arrington
Rohan Desai
Prakrati C. Acharya
Published in
Current Cardiology Reports | Issue 5/2024

Abstract

Purpose of Review

The polypill strategy, originally developed to improve medication adherence, has demonstrated efficacy in improving baseline systolic blood pressures and cholesterol levels in multiple clinical trials. However, the long-term clinical impact of improved major cardiovascular events (MACE) outcomes by the polypill remains uncertain.

Recent Findings

Recent trials with long-term follow-up, which included minority groups and people with low socioeconomic status, have shown non-inferiority with no difference in adverse effects rates for the secondary prevention of MACE.

Summary

Although the polypill strategy was initially introduced to improve adherence to guideline-directed medical therapy (GDMT) for cardiovascular complications, the strategy has surpassed standard medical treatment for secondary prevention of MACE outcomes. Studies also showed improved medication compliance in underserved populations.
Title
Polypill Strategy in Secondary Cardiovascular Prevention
Authors
Alan De la Rosa
Kedzie Arrington
Rohan Desai
Prakrati C. Acharya
Publication date
01-04-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 5/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02046-1
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
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Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME