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Open Access 17-08-2024 | Acute Coronary Syndrome | Review

Milvexian: An Oral, Bioavailable Factor XIa Inhibitor

Authors: Shyon Parsa, Sneha S. Jain, Olu Akinrimisi, Carolyn S. P. Lam, Kenneth W. Mahaffey

Abstract

Direct oral anticoagulants have a dose-dependent increased bleeding risk which limits use in certain populations. Studies in both animals and humans with inherited variations in factor XI levels provide a theoretical basis for a drug target capable of addressing current unmet needs. Milvexian is an oral factor XIa inhibitor that has the potential to provide robust anticoagulant effect without increased bleeding compared with current standard of care. Several key studies in the preclinical, phase I, and phase II stages have reported promising safety data in venous thromboembolism and stroke prevention without compromising hemostasis. The planned phase III trials will examine the efficacy of milvexian for prevention of thrombotic events in patients with acute stroke, acute coronary syndrome, and atrial fibrillation.

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Title: Milvexian: An Oral, Bioavailable Factor XIa Inhibitor
Authors: Shyon Parsa
Sneha S. Jain
Olu Akinrimisi
Carolyn S. P. Lam
Kenneth W. Mahaffey
Publication date: 17-08-2024
Publisher: Springer Healthcare
Keywords: Acute Coronary Syndrome
Cerebral Ischemic Stroke
Atrial Fibrillation
Cerebral Ischemia
Enoxaparin
Venous Thrombosis
Published in: Cardiology and Therapy
Print ISSN: 2193-8261
Electronic ISSN: 2193-6544
DOI: https://doi.org/10.1007/s40119-024-00379-0

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Milvexian: An Oral, Bioavailable Factor XIa Inhibitor

Abstract

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Abstract

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2024 ESC Congress

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Low Lp(a) levels unlikely to increase the risk of diabetes

» View more highlights on the 2024 ESC Congress hub page

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